Search results

Background:The SLUG transcription factor has been linked with the KIT signalling pathway that is important for gastrointestinal stromal tumour (GIST) tumourigenesis. Its clinical significance in GIST is unknown.Methods:Influence of SLUG expression on cell proliferation and viability were investigated in GIST48 and GIST882 cell lines. The association between tumour SLUG expression in immunohistoche

This work presents a photodissociation study of the diamondoid adamantane using extreme ultraviolet femtosecond pulses. The fragmentation dynamics of the dication is unraveled by the use of advanced ion and electron spectroscopy giving access to the dissociation channels as well as their energetics. To get insight into the fragmentation dynamics, we use a theoretical approach combining potential e

Objective: The Systemic Lupus International Collaborating Clinics (SLICC) frailty index (FI) has been shown to predict mortality, but its association with other important outcomes is unknown. We examined the association of baseline SLICC FI values with damage accrual in the SLICC inception cohort. Methods: The baseline visit was defined as the first visit at which both organ damage (SLICC/American

Background: Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives: To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients w

Agroforestry practices support agricultural resilience against climatic variability, increase soil productivity, can diversify and increase farmers' incomes, and support native fauna in agricultural landscapes. However, many farmers are still reluctant to implement agroforestry practices. We distributed questionnaires to 75 agroforestry and 64 "conventional agriculture" small-scale farmers working

Attosecond pulses are central to the investigation of valence- and core-electron dynamics on their natural timescales1–3. The reproducible generation and characterization of attosecond waveforms has been demonstrated so far only through the process of high-order harmonic generation4–7. Several methods for shaping attosecond waveforms have been proposed, including the use of metallic filters8,9, mu

PURPOSE OF REVIEW: To discuss new findings on the heterogeneity of obesity and associated risks.RECENT FINDINGS: Obesity is a public health problem of immense importance on a global scale. However, epidemiological findings and clinical studies have revealed that obesity is a heterogeneous phenotype and that not all obese subjects run the same risk for complications. Current research has tried to d

Turkiets president Erdoğan vill skapa ett neo-osmanska kalifat, istället för det gamla som upplöstes efter första världskriget. I sina senaste uttalande på Twitter kräver Erdoğan en ny världsordning.

Folkbildningsrådet och de kristna studieförbunden Sensus och Bilda tycks nu fortsätta samarbetet med Ibn Rushd som om inget har hänt. Jag befarar därför att förtroendekrisen nu kommer att flyttas till Folkbildningsrådet och de båda kristna studieförbunden: Sensus och Bilda. Särskilt Sensus får bära ett stort ansvar för denna kris.

Studieförbundet Ibn Rushd bör avskiljas helt från inflytande och penningkranarna.

Huma skiljer inte mellan hur en religiös text skapades, hur den tolkades i historisk social kontext och hur texten bör tolkas idag. De religiösa påbud Huma följer är skrivna av män och har tolkats av män i en patriarkalisk kontext.

Paper på temat Holocaust Memory and Representation in Sweden

Background Frontotemporal dementia (FTD) is a pathologically heterogeneous neurodegenerative disorder associated usually with tau or TDP-43 pathology, although some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with Alzheimer's disease pathology. Currently, there are no biomarkers able to diagnose the underlying pathology during life. In this study,

Purpose: Studies comparing CSF and PET tau biomarkers have included only commercial CSF assays examining specific phosphorylation sites (e.g. threonine 181, P-tau 181p ) and mid-domain tau (i.e. total tau, T-tau). Moreover, these studies did not examine CSF tau levels in relation to cerebral glucose metabolism. We thus aimed to examine CSF tau measures, using both commercial and novel assays, in

Background: Cerebrospinal fluid (CSF) biomarkers have gained increasing importance in the diagnostic work-up of Alzheimer's disease (AD). The core CSF biomarkers related to AD pathology (Aβ42, t-tau and p-tau) are currently used in CSF diagnostics, while candidate markers of amyloid metabolism (Aβ38, Aβ40, sAPPα, sAPPβ), synaptic loss (neurogranin), neuroinflammation (YKL-40), neuronal damage (VIL

Given the growing use of cerebrospinal fluid (CSF) beta-amyloid (Aß) and tau as biomarkers for early diagnosis of Alzheimer's disease (AD), it is essential that the diagnostic procedures are standardized and the results comparable across different laboratories. Preanalytical factors are reported to be the cause of at least 50% of the total variability. Among them, diurnal variability is a key issu

Since diagnosis of Parkinson's disease (PD) is mostly based on clinical criteria, it is almost impossible to formulate an early diagnosis, as well as a timely differential diagnosis versus other parkinsonisms. A great effort in searching reliable biomarkers both for early diagnosis and prognosis in PD is currently ongoing. Cerebrospinal fluid has been widely investigated as potential source for su