MMP12 is a metalloproteinase implicated in inflammation. To monitor its activity, we synthesized a membrane-targeted reporter (LaRee1) based on Foerster resonance energy transfer (FRET). Unlike existing sensors, LaRee1 detects MMP12 activity by loss of FRET plus internalization of the lipidated fragment. In bronchoalveolar lavages from a mouse model of pulmonary inflammation, LaRee1 detected MMP12

When Iran directed over 300 missiles and drones at Israel on April 13, Jordan helped fend off the attack. Initial media reports suggested that several other Arab states assisted in Israel’s defense, efforts they later denied. Nonetheless, a chorus of Israeli leaders, as well as some observers in Washington, interpreted these acts as a sign of a major shift. These Arab states, the argument went, wo

Health inequalities are a persistent and growing issue in different countries worldwide. Sweden, despite being one of the scandinavian countries with internationally recognized welfare system is no exception. The issue of health disparities and its increase among some groups, including those who are categorised as migrant have been acknowledged. Emergence of the COVID-19 pandemic, however, reveale

Abstract:Background Type 1 diabetes (T1D) is one of the most common childhood autoimmune diseases, with rising incidence worldwide with a male predominance. The etiology behind the disease is mostly unknown and it is essential to understand the factors that impact its development to prevent the disease and personalize the treatment. This thesis aims to examine sex-specific differences in T1D, expl

BACKGROUND: In the European Union alone, more than 100 million people present to the emergency department (ED) each year, and this has increased steadily year-on-year by 2-3%. Better patient management decisions have the potential to reduce ED crowding, the number of diagnostic tests, the use of inpatient beds, and healthcare costs.METHODS: We have established the Skåne Emergency Medicine (SEM) co

INTRODUCTION: With the implementation of early reperfusion therapy, the number of complications in patients with acute coronary syndrome (ACS) has diminished significantly. However, ACS patients are still routinely admitted to units with high-level monitoring such as the coronary or intensive care unit (CCU/ICU). The cost of these admissions is high and there is often a shortage of beds. The aim o

Deep electrification powered by renewable sources has emerged as a pivotal strategy for achieving ambitious CO2 emission reduction targets. However, the true impact of electrification on decarbonization remains inadequately measured because the whole energy chain has not yet been fully considered. This study combines Societal Exergy Accounting and Logarithmic Mean Divisia decomposition analysis to

We contribute to the argument for a “new” business history employing a quantitative approach. We illustrate opportunities for new perspectives from this approach using a novel microlevel longitudinal database comprising 131 variables for 1,419 cooperative creameries in Denmark for the period 1898–1945, which we also document and make available to the scholarly community. We present a number of app

Our objective was to pilot test an electronic health record-embedded decision support tool to facilitate prostate-specific antigen (PSA) screening discussions in the primary care setting. Methods We pilot-tested a novel decision support tool that was used by 10 primary care physicians (PCPs) for 6 months, followed by a survey. The tool comprised (1) a risk-stratified algorithm, (2) a tool for faci

One of the required communication solutions to support novel use cases, e.g. in industrial environments, for 5G systems and beyond is ultra-reliability low-latency communication (URLLC). An enabling technology for URLLC is massive multiple-input multiple-output (MIMO), which with its large antenna arrays can increase reliability due to improved user separation, array gain and the channel hardening

The end-of-life recycling of crystalline silicon photovoltaic (PV) modules and the utilisation of waste is of fundamental importance to future circular-economy societies. In the present work, the wet-chemistry synthesis route - a low-temperature dissolution-precipitation process - was explored to produce aluminosilicate minerals from waste c-Si solar cells. Nanostructured crystals were produced in

Remote care is a growing area in healthcare, due to fast technological development offering suitable equipment and platform for distant medical consultation and care. Remote care includes a promise towards care that has the potential to improve the patient's quality of life, prevent unnecessary reception visits, reduce costs, and enable timely and early therapeutic intervention in situations where

Background: Palliative care (PC) is an integral part of cancer treatment. However, data on service availability is limited in childhood cancers. Aim: To describe the availability of PC services in paediatric oncology centres across Europe, and to identify barriers and facilitators for implementing and providing paediatric palliative care (PPC). Methods: Paediatric oncology centres across Europe we

This article develops the concept of community lore, initially devised by the social learning theorists Jean Lave and Etienne Wenger (1991). In extending this promising but hitherto neglected aspect of their work, this article sheds light on how and why community lore sustains and propels teaching and learning in the contemporary esoteric society Sodalitas Rosae Crucis (SRC). Ethnographic findings

Gröna och artrika utemiljöer främjar barns och ungas välbefinnande och kunskap, bådegenom hälsofördelar kopplade till biologisk mångfald och genom att skapa förutsättningarför lek och lärande om natur och miljöfrågor. Skolgården skulle kunna bidra till allt detta,men är idag i hög grad en outnyttjad plats för biologisk mångfald och klimatanpassningav städer. I denna policy brief presenteras huvuds

Urban spaces should be resilient, inclusive and safe for all residents including children, elderly and vulnerable groups. This implies that urban planning, management and design should provide public spaces that support human needs of active mobility, social interaction and psychological restoration across seasonal and diurnal variation in natural light. Environmental psychology postulates that an

Rapporten utgör ett underlag till Jämställdhetsmyndighetens fördjupadeuppföljning av det jämställdhetspolitiska delmålet att mäns våld mot kvinnor skaupphöra.

divided the data set temporally, assessing the persistence of identified subgroups over different periods. The reassessment of mortality risk used the targeted maximum likelihood estimation (TMLE) method to achieve more robust causal modeling. Results: We analyzed data from 21,005 children. The mortality risk (6 weeks to 3 years of age) was 5.2% (95% CI 4.8%-5.6%) for children born between 2003 an

Purpose: The aim of this study was to investigate the contrast mechanisms of Contrast-enhanced steady-state free-precession (CE-SSFP) through the utilization of Bloch simulations in an experimental porcine model and in patients with acute myocardial infarction. Methods: Six pigs and ten patients with myocardial infarction underwent CMR and tissue characterization at 1.5 T whereas a Bloch simulatio