Background Colorectal cancer is a leading cause of cancer related death worldwide. 20-30 % of patients will develop colorectal liver metastases (CRLMs). Surgical resection is the mainstay of treatment for CRLMs, and is often combined with perioperative chemotherapy, which can prolong progression-free survival after resection. Moreover, observation of CRLMs response to preoperative chemotherapy can

For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem, we introduce persistent homology as a rigorous framework that can be used to both define For nearly three decades, spatial games have produced a wealth of insights to the study of behavior and its relation to population structure. However, as different rules and factors are added or altered, the dynamics of spatial models often become increasingly complicated to interpret. To tackle this problem,we introduce persistent homology as a rigorous framework that can be used to both define a

Petroleum, contains proportions of contaminants such as sulfur, nitrogen, oxygen, and metals, such as nickel, iron, copper, sodium, and vanadium. Particularly, contaminants containing sulfur cause problems during handling, transportation, and the use of the their derivatives. This work had the goal of cracking the heavy crude oil molecules by reacting these molecules with tetralin and simultaneous

In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yi

Aim: The aim was to determine body composition and growth in preterm infants based on two different feeding regimens and to assess how standard and individual fortification (IF) affect energy and protein intake. Body composition was assessed at full term and at four months corrected age. Methods: Sixty preterm infants born before gestational week 32 were randomized either to IF of mother’s breast

Emissions from aviation are expected to grow. With evidence that the International Civil Aviation Organization’s Carbon Offsetting and Reduction Scheme for International Aviation is an inadequate mitigation mechanism, there is interest in upscaling the sector’s climate-related policies. This paper reviews potential aviation emissions mitigation policies against the background of emerging complexit

Secondary mitral regurgitation (MR) occurs despite structurally normal valve apparatus due to an underlying disease of the myocardium leading to disruption of the balance between tethering and closing forces with ensuing failure of leaflet coaptation. In patients with heart failure (HF) and left ventricular dysfunction, secondary MR is independently associated with poor outcome, yet prognostic ben

Atherosclerosis is a lipid-driven, chronic inflammatory disease. In spite of efficient lipid lowering treatments, such as statins and PCSK9 inhibitors, patients, especially those with elevated inflammatory biomarkers, still have a significant residual cardiovascular disease risk. Novel drugs targeting inflammatory mediators are needed to further reduce this residual risk. Agonistic immune checkpoi

Background: Stroke and dementia are interrelated diseases and risk for both increases with age. Even though stroke incidence and age-standardized death rates have decreased due to prevention of stroke risk factors, increased utilization of reperfusion therapies, and other changes in healthcare, the absolute numbers are increasing due to population growth and aging. Objective: To analyze predictors

Thrombocytopenia results from a variety of conditions, including radiation, chemotherapy, autoimmune disease, bone marrow disorders, pathologic conditions associated with surgical procedures, hematopoietic stem cell transplant (HSCT), and hematologic disorders associated with severe aplastic anemia. Immune thrombocytopenia (ITP) is caused by immune reactions that accelerate destruction and reduce

Introduction: Inhibitors develop less frequently in haemophilia B (HB) than haemophilia A (HA). However, when present, the success of tolerization by immune tolerance induction (ITI) therapy is lower and the risk of complications higher. Aim: To evaluate the use and outcome of ITI in patients with HB and inhibitors. Methods: Subjects include singletons or siblings with a current/history of inhibit

Purpose: High-performing imaging and predictive markers are warranted to minimize surgical overtreatment of the axilla in breast cancer (BC) patients receiving neoadjuvant chemotherapy (NACT). Here we have investigated whether axillary ultrasound (AUS) could identify axillary lymph node (ALN) metastasis (ALNM) pre-NACT and post-NACT for BC. The association of tumor, AUS features and mammographic d

By disrupting investment, supply chains and technology diffusion, COVID-19 may harm renewables more than coal, but still weaken coal lock-in in developing countries. To enable new low-carbon energy choices, international flows of low-carbon technology and policy expertise must quickly re-emerge.

Industrial lignin such as kraft lignin is an abundant feedstock for renewable chemicals and materials. In this study, a process was developed for depolymerization of kraft lignin followed by an upgrading separation step and further bioconversion of the obtained monoaromatic compounds to muconic acid. First, industrial kraft lignin, Indulin AT, was processed into a guaiacol-rich stream using base-c

There are fundamental unresolved questions about the nature of the long-run interplay between innovation and economic development processes. This study examines technological transitions in Sweden, 1908-2016, using a new literature-based innovation output indicator for the engineering industry, allowing a mixed-methods approach. The results suggest that waves of innovation have taken place during

Wildfires are expected to increase with warmer climate, which can contribute to the mobility and the resuspension of long-lived and potentially hazardous radionuclides. The release of 137Cs during combustion of dried litter, forest floor organic soil, and peat was investigated in a small-scale experimental set-up. Combustion conditions were varied to simulate different wildfire scenarios, and the

Gadolinium-148 is one of the radionuclides of most concern that will be produced in the tungsten target of the European Spallation Source (ESS), as a by-product of the spallation reaction used by the facility to produce neutrons. Since 148Gd a pure alpha emitter, it is both very radiotoxic and difficult to measure. With its half-life of 75 years, it will remain in the environment for a long time i

PURPOSE: To investigate the patterns of healthcare use (HCU) at the last year of life in persons with osteoarthritis (OA).METHODS: Using linked registers, we identified persons aged≥ 65 years who died during 2003-2014 and were resided in the Skåne region during 5-year prior to death. Among these, we randomly matched decedents with a principal OA diagnosis prior to the last year of life (OA cohort,