Background: Familial adenomatous polyposis (FAP) is typically characterized by multiple colonic polyps and frequent extracolonic features. Whereas the number of colonic polyps has been linked to the APC gene mutation, possible genotype-phenotype correlations largely remain to be defined for the extracolonic manifestations. Methods: Full genomic sequencing combined with multiplex ligation-dependent

Recension av en doktorsavhandling i polsk litteratur, försvarad vid Uppsala universitet i december 2011.

Background: Neuroendocrine (NE) differentiation in prostate cancer has been correlated with a poor prognosis and hormone refractory disease. In a previous report, we demonstrated the presence of immunoreactive cytoplasmic hypoxia inducible factor 1 alpha (HIF1 alpha), in both benign and malignant NE prostate cells. HIF1 alpha and HIF1 beta are two subunits of HIF1, a transcription factor important

We present the open-source software framework in JModelica.org for numerically solving large-scale dynamic optimization problems. The framework solves problems whose dynamic systems are described in Modelica, an open modeling language supported by several different tools. The framework implements a numerical method based on direct local collocation, of which the details are presented. The implemen

Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via

The representation of crowd movement in existing evacuation models is typically based on data collected in the 1950s to 1980s, i.e., data that are more than 40 years old. Since the 1970s, population characteristics have changed dramatically around the world. Reports show that the percentage of elderly and obesity rates have increased significantly and this trend is predicted to continue into the f

The evolution of maternal effects on offspring phenotype should depend on the extent of parent-offspring conflict and costs and constraints associated with maternal and offspring strategies. Here, we develop a model of maternal effects on offspring dispersal phenotype under parent-offspring conflict to evaluate such dependence. In the absence of evolutionary constraints and costs, offspring evolve

In 1999 and 2004, we published reports on how the introduction of 20 males into a severely inbred and isolated population of Adders (Vipera berus) halted its decline towards extinction. The introduction significantly enhanced the population's genetic variability, which resulted in a dramatic increase in offspring viability and a rapid increase in numbers. Unfortunately, recently a new and unpreced

Electron energy loss spectroscopy (EELS) and cathodoluminescence (CL) have proved during the past few years to be tremendous tools to study surface plasmons in metallic nanoparticles, thanks to an extremely high spatial resolution combined with a broad spectral range. Despite their apparent close resemblance, qualitative differences between EELS and CL have been theoretically as well as experiment

Ferroelectric materials offer a variety of new applications in the field of smart structures and intelligent systems. Accordingly, the modelling of these materials constitutes an active field of research. A critical limitation of the performance of such materials is given when electrical, mechanical, or mixed loading fatigue occurs, combined with, for instance, microcracking phenomena. In this con

Presentation av och kommentarer till ett nyupptäckt originalmanuskript (spexmanus) av Axel Wallengren och John Wigforss.

This work demonstrates single-shot holography with ultrashort XUV pulses. The pulses are generated by high-harmonic generation in an Ar gas cell and focused to produce a strongly divergent reference beam suitable for in-line holography of micrometer size objects. The achieved intensity of the high-order harmonics in the XUV regime is sufficient for single-shot holography with good signal-to-noise

Background: To evaluate the pattern of co-infection of human papillomavirus (HPV) types in both sexes in Sweden. Methods: Cell samples from genital swabs, first-void urine, and genital swabs immersed in first-void urine were collected in the present cross-sectional High Throughput HPV Monitoring study. Overall, 31,717 samples from women and 9,949 from men (mean age 25) were tested for 16 HPV types

Pacini G, Ahren M, Ahren B. Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice. Am J Physiol Regul Integr Comp Physiol 296: R1316-R1324, 2009. First published February 11, 2009; doi: 10.1152/ajpregu.90575.2008.- Mice are increasingly used in studies where measuring insulin sensitivity (IS) is a common procedure. The glucose clamp is labor

The objective of this study has been to develop technologies that can reduce the content of active pharmaceutical ingredients (APIs) and bacteria from hospital wastewater. The results from the laboratory-and pilot-scale testings showed that efficient removal of the vast majority of APIs could be achieved by a membrane bioreactor (MBR) followed by ozone, ozone + hydrogen peroxide or powdered activa

We evaluated the predictive value of interim positon emission tomography (I-PET) after one course of chemoimmunotherapy in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL). One hundred and twelve patients with DLBCL were enrolled. All patients had PET/computed tomography (CT) scans performed after one course of chemotherapy (PET-1). I-PET scans were categorized according to Inte

Brevican is known to be an abundant extracellular matrix component in the adult brain and a structural constituent of perineuronal nets. We herein show that brevican, tenascin-R (TN-R) and phosphacan are present at the nodes of Ranvier on myelinated axons with a particularly large diameter in the central nervous system. A brevican deficiency resulted in a reorganization of the nodal matrices, whic

Due to the possibility of increased efficiency and reduced emissions, Homogeneous Charge Compression Ignition (HCCI) is a promising alternative to conventional internal combustion engines. Ignition timing in HCCI is highly sensitive to operating conditions and lacks direct actuation, making it a challenging subject for closed-loop control. This paper presents physics-based, control-oriented modeli

Background: Blood lead concentrations (B-Pb) were measured in 3 879 Swedish school children during the period 1978-2007. The objective was to study the effect of the proximity to lead sources based on the children's home and school location. Methods: The children's home address and school location were geocoded and their proximity to a lead smelter and major roads was calculated using geographical