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Predictive validity of the K-SADS-PL 2009 version in school-aged and adolescent outpatients

Background: The schedule for affective disorders and schizophrenia for school-age children (K-SADS) is one of the most commonly used standardized diagnostic interviews in child and adolescent psychiatry. Validity studies are scarce, and limited to concurrent validity with other measures and clinical diagnoses. Aims: To evaluate the K-SADS interview in an outpatient child and adolescent psychiatry

Clinical Findings and Outcome after Stroke. Including a Translational Stem Cell Therapy Perspective.

Background and Purpose: Stroke is one of the dominant causes of death and adult disability in the world. There is a need for novel therapeutic approaches to improve functional recovery and outcome after stroke, and experimental studies have shown that stem cell-based therapies (SCT) hold much potential in this regard. This thesis, comprising 5 papers, aims to explore and describe clinical symptoms

Competence and confusion : How stereotype threat can make you a bad judge of your competence

Women tend to have competence doubts for masculine-stereotyped domains (e.g., math), whereas men tend to think they can handle both feminine-stereotyped and masculine-stereotyped domains equally well. We suggest that perhaps women's more frequent experience with stereotype threat can partly explain why. Our results showed that when stereotype threat was primed in high school students (n = 244), th

In situ light dosimetry during whole bladder wall photodynamic therapy : clinical results and experimental verification

Photodynamic therapy (PDT) using Photofrin IIR (PII) as a photosensitizer is currently being evaluated as a new treatment modality for superficial bladder cancer. An optimum therapeutic ratio requires uniform illumination of the whole bladder wall and accurate light dosimetry. The first clinical light dosimetry results (16 patients) are reported, obtained using a system which allows in situ measur

On the Fourier dimension and a modification

We give a sufficient condition for the Fourier dimension of a countable union of sets to equal the supremum of the Fourier dimensions of the sets in the union, and show by example that the Fourier dimension is not countably stable in general. A natural approach to finite stability of the Fourier dimension for sets would be to try to prove that the Fourier dimension for measures is finitely stable,

Global HDO uptake in human glioma xenografts is related to the perfused capillary distribution

The aim of this study is to evaluate the existence of a possible relationship between global deuterium-labeled water (HDO) uptake rates and the diffusion geometry of human glioma xenografts in nude mice. HDO diffusion times in the whole extravascular tumor volume were estimated by combining quantitative (1)H-MR diffusion imaging and morphometric analysis of intercapillary distances in two tumor li

Effects of ischemia on skeletal muscle energy metabolism in mice lacking creatine kinase monitored by in vivo 31P nuclear magnetic resonance spectroscopy

The aim of this study was to provide in vivo experimental evidence for the proposed biological significance of the creatine kinase (CK)/phosphocreatine (PCr) system in the energy metabolism of skeletal muscle. As a test system we compared hindlimb muscle of knockout mice lacking the cytosolic M-type (M-CK(-)/(-)), the mitochondrial ScMit-type (ScCKmit(-)/(-)), or both creatine kinase isoenzymes (C

Proton MR spectroscopy of wild-type and creatine kinase deficient mouse skeletal muscle : dipole-dipole coupling effects and post-mortem changes

Localized proton MR spectra of mouse skeletal muscle obtained at 7 T show dipole-dipole coupling effects for creatine and putative taurine resonances and for the lactate methine signal. These effects are independent of the presence of creatine kinase. The intensity of the methylene (1)H resonance of creatine is not different between wild-type and creatine kinase deficient mice, which have a lower

Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle

31P magnetic resonance spectroscopy (MRS) offers a unique non-invasive window on energy metabolism in skeletal muscle, with possibilities for longitudinal studies and of obtaining important bioenergetic data continuously and with sufficient time resolution during muscle exercise. The present paper provides an introductory overview of the current status of in vivo 31P MRS of skeletal muscle, focusi

Automatic correction for phase shifts, frequency shifts, and lineshape distortions across a series of single resonance lines in large spectral data sets

A new model-free method is presented that automatically corrects for phase shifts, frequency shifts, and additional lineshape distortions of one single resonance peak across a series of in vivo NMR spectra. All separate phase and frequency variations are quickly and directly derived from the common lineshape in the data set using principal component analysis and linear regression. First, the new a