Filetype
BackgroundDepression in older adults poses significant health challenges, yet the protective role of positive affect remains understudied. This research examined the complex network of positive affect and depression in older adults using advanced network analysis techniques to identify potential targets for intervention.MethodsBayesian Gaussian Graphical Models and Directed Acyclic Graph modelling
BackgroundObsessive-compulsive symptoms (OCS) often emerge during childhood and adolescence, and two aetiological models have been proposed. According to the first model, maladaptive cognitive beliefs facilitate the transformation of transient intrusive thoughts into OCS. The second model suggests that dysfunctional cognitive beliefs develop in response to increased levels of OCS. Few studies have
Sverige står inför växande behov av investeringar i olika slags infrastruktur samtidigt som många andra utgiftsområden förväntas öka. Offentlig-privat samverkan (OPS) kan vara ett värdefullt komplement till traditionellt utförande eftersom den skapar starkare incitament för effektivitet, livscykeltänkande och innovation. Den här rapporten sammanfattar internationell forskning på området och konsta
Background There is limited knowledge on whether prior knee surgery impacts the clinical profile and treatment outcomes for individuals with knee osteoarthritis (OA). Objectives The study aimed to (i) compare individual and clinical characteristics, and (ii) evaluate whether outcomes of first-line treatment differ between individuals with prior knee surgery and those without. Methods This study us
Medical, neurological, and substance use disorders constitute a major disease burden worldwide, but especially in low- and middle-income countries (LMICs) where more than 80% of affected persons are unable to receive evidence-supported treatments despite these being widely available in theory. This persistent mental health treatment gap in LMICs is traceable to the very nature of such nations: low
Global health is a multidisciplinary field focused on improving health and achieving equity in health for all people worldwide. The COVID-19 pandemic left a profound and lasting impact on global mental health, triggering a surge in anxiety, depression, and stress-related disorders across all age groups and regions. As the world transitions into the post-COVID period, mental health has emerged as a
The mental health of the health workforce has been receiving more attention, especially since the pandemic. Levels of burnout, moral injury, and mental disorders, including suicide, among physicians are cause for concern. Healthcare leadership in workplaces plays a crucial role in addressing this important issue, which is also related to the ability to attract and retain physicians. This chapter p
Introduction: Non-suicidal self-injury (NSSI) is often met with stigma, which can deter individuals from seeking help. While most research on NSSI stigma has focused on clinical settings, the attitudes of those most likely to receive an NSSI disclosure, such as peers, friends, and family, remain underexplored. Building on qualitative findings that positive disclosure experiences can foster support
Importance: General practitioners (GPs) sometimes initiate a treatment despite not expecting it to improve patients' symptoms by any physiological mechanism. These essentially placebo treatments are ethically controversial, and their frequency is unclear. They involve risks for patients, but to estimate these, more data are needed. Objective: To develop a more precise overview of the rate at which
A majority of all infectious diseases manifest some climate-sensitivity. However, many of those sensitivities are not well understood as meteorological drivers of infectious diseases co-occur with other drivers exhibiting complex non-linear influences and feedback. This makes it hard to dissect their individual contributions. Here we apply a novel deep learning Explainable AI (XAI) compartment mod
It is a continued open question how there can be an azimuthal anisotropy of high p⊥ particles quantified by a sizable v2 in p+Pb collisions when, at the same time, the nuclear modification factor RAA is consistent with unity. We address this puzzle within the framework of the jet quenching model Jewel. In the absence of reliable medium models for small collision systems we use the number of scatte
Group exhibition.With beyond now. Editions, the Kestner Gesellschaft reflects on its exhibition history and the connection between artistic production and institutional work. This special exhibition includes both current and rediscovered limited-edition works, combining them with a series of related exhibition posters. A visual timeline traces the historical context of the works, their thematic co
INTRODUCTION: Social prescribing (SP) is an innovative model that connects individuals to non-clinical community resources. However, its uptake and evaluation have been hindered by inconsistent role definitions for key stakeholders. Although recent studies have refined SP definitions, outside the UK, the responsibilities, educational backgrounds and training requirements of social prescribing link
Highlights: What are the main findings? Health for adolescents with depression was described in terms of managing everyday life, building confidence and trust, experiencing joy in life, and supporting well-being. These aspects reflect how health can be understood through daily routines, relationships, emotional experiences, and lifestyle habits. What is the implication of the main finding? The fin
Advances in quantum computing pose a fundamental threat to classical public-key cryptosystems, including RSA and elliptic-curve cryptography (ECC), which form the foundation for authentication and key exchange in the Transport Layer Security (TLS) protocol. In response to these emerging threats, Korea launched the KpqC (Korea Post-Quantum Cryptography) project in 2021 to design, evaluate, and stan
Background/Objectives: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated host response to infection. Mitochondrial dysfunction is considered a key contributor to the pathogenesis of sepsis, but its molecular mechanisms remain unclear. Methods: In this study, we used a cecal ligation and puncture (CLP) model to induce sepsis in wild-type (WT) and cyclop
Proteins and peptides are vital biomolecules, and deuterated amino acids are increasingly applied in areas such as drug discovery, metabolic tracing, and neutron scattering studies. In this study, we performed deuteration on all 20 proteinogenic amino acids, including their side chains, and established efficient methods for 13 amino acids. Using a Pt/C-catalyzed hydrogen–deuterium exchange reactio
