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BACKGROUND: In patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) and who are treated with direct oral anticoagulants (DOACs), dual antithrombotic treatment without aspirin is recommended. Evidence comparing P2Y 12 inhibitor strategies in this setting is limited. AIMS: This study aimed to compare outcomes with ticagrelor versus clopidogrel as part of

INTRODUCTION: We assessed the accuracy of the Amsterdam Instrumental Activities of Daily Living Questionnaire (A-IADL-Q) for clinical staging in Swedish primary care.METHODS: Participants from the Swedish BioFINDER Primary Care study were included. Discriminative performance of the A-IADL-Q was evaluated using receiver operating curves. Multinomial and linear regression models assessed association

Heavy-duty transport is one of the major contributors to global greenhouse gas (GHG) emissions, with internal combustion engines (ICEs) expected to remain an important propulsion technology in long-haul applications during the transition to sustainable transport. The use of renewable gaseous fuels such as biogas and hydrogen offers a promising pathway to significantly reduce the climate impact of

Neoliberal welfare reforms and limited pathways to permanent residency have left migrant women, among other groups, with little or no access to public social protection, contributing to their precarious legal status. As a result, civil society actors (CSA) have become the main providers of support and deliver micro-level social protection beyond the boundaries of public authorities. At the same ti

p53 protein accumulation and gene mutation have been implicated in resistance to cytotoxic treatment. This study was performed to further assess the predictive value of p53 in breast cancer. Postmenopausal patients were randomized to adjuvant chemotherapy with cyclophosphamide, metothrexate, or 5-fluorouracil (CMF) vs. postoperative radiotherapy. The patients were also randomized to adjuvant tamox

Scholars have shown that lifestyle change is pivotal for any effective climate-mitigation scenario. But what lifestyle changes are needed and how can they be enabled and mainstreamed? This is the question pursued by the EU 1.5° Lifestyles project, the results of which the article summarizes and synthesizes. The project integrated quantitative and qualitative methods, ranging from input-output anal

The aim of this study was to investigate the frequency of p53 alterations in bilateral breast cancer and to evaluate a possible clonal relationship between the paired tumours regarding p53 alteration and other pathobiological variables. Tumours from 34 patients were investigated with immunohistochemistry, single strand conformation polymorphism analysis and DNA-sequence analysis applied to exons 5

Accumulation of the tumour-suppressor protein p53 in breast cancer is associated with several prognostic factors that indicate an aggressive, rapidly proliferating tumour with an unstable genome. To assess p53 accumulation in stage I breast cancer and to evaluate the prognostic value of both nuclear and cytoplasmic p53, 205 patients with node-negative breast cancer and tumour size less than or equ

Functional p53 protein is essential for the cellular response to drug-induced DNA damage. We investigated p53 accumulation in tumour specimens from premenopausal breast cancer patients who were randomised to adjuvant chemotherapy (CMF) or postoperative radiotherapy. Of the tumours from 139 patients, 20 showed abnormal accumulation as judged with immunohistochemistry (> 10% positive tumour cells).