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Partial hemitransection was performed through a knife lesion at the meso-diencephalic level in rats to sever the mesostriatal dopamine system. During the subsequent 2 weeks the animals received 0.125 mg/kg/h of nicotine continuously via an osmotic minipump implanted s.c. To achieve prompt high nicotine levels, 4 i.p. injections of 0.5 mg/kg nicotine were, in addition, given during the first 2 h fo

Abstract The yeast Saccharomyces kluyveri (Lachancea kluyveri), a far relative of Saccharomyces cerevisiae, is not a widely studied organism in the laboratory. However, significant contributions to the understanding of nucleic acid precursors degradation in eukaryotes have been made using this model organism. Here we review eukaryotic pyrimidine degradation with emphasis on the contributions made

Background Empirical data about end-of-life decision-making practices are scarce. We aimed to investigate frequency and characteristics of end-of-life decision-making practices in six European countries: Belgium, Denmark, Italy, the Netherlands, Sweden, and Switzerland. Methods In all participating countries, deaths reported to death registries were stratified for cause (apart from in Switzerland)

GRACILE syndrome (growth retardation, aminoaciduria, cholestasis, iron overload, lactacidosis, and early death; OMIM 603358) is a rare metabolic disorder with autosomal recessive mode of inheritance. So far it has been diagnosed only in patients with Finnish ancestors. The GRACILE locus has been positioned to a restricted region of chromosome 2q33-37, but the causative gene remains to be identifie

This paper argues for the relevance of the media history of the press. Using a broad and open media concept, this perspective should be understood as the study of the construction and communication of the self-images and ideology of the press. Rather than describing the complex of problems as images that are ‘spread’ through one channel (newspapers) by one actor (the press), it should be seen as a

When describing isokinetic effects by the model of selective energy transfer by resonance, it is sometimes found that the frequency of the forcing oscillator is quite different to that of the reacting molecule, i.e."resonance" is not a very good concept to use. By noting that the two frequencies thus found are related to each other as the ratios of small integers, e.g. 4:3, this dilemma is resolve

Atomic processes like e.g. molecular vibrations, chemical reactions or phase transitions happen on picosecond down to femtosecond time scales. Novel pulsed X-ray sources or alternatively ultrafast X-ray detectors allow the investigation of these processes in real time. A powerful tool for the investigation of the dynamics in crystalline materials is time resolved X-ray diffraction (TRXD). As an ex

Researchers studying individual variation in conspicuous skin coloration in primates have suggested that color indicates male quality. Although primate fur color can also be flamboyant, the potential condition dependence and thus signaling function of fur remains poorly studied. We studied sources of variation in sexually dichromatic facial hair coloration in red-fronted lemurs (Eulemur fulvus ruf

In this first part of a research project a phenomenological approach was applied to understanding student nurses' experience of preceptorship. The lived experience of seventeen student nurses learning within a preceptor-preceptee relationship on hospital wards formed the basis of the study. Tape-recorded interviews were conducted, transcribed and analysed. The phenomenological hermeneutic analysis

Film extrusion and welding of biodegradable polymer films are important processes that must be considered in the development of compostable packaging materials. Film extrusion of poly(lactic acid) (PLA) has proved to be rather difficult because of its brittleness, but the flexibility of PLA can be improved by incorporation of a plasticizer in the material. PLA was plasticized with triacetine (TAc)

Aims Unnecessary right ventricular pacing has deleterious effects and becomes more significant when cumulative percent ventricular pacing (Cum%VP) exceeds 40% of time. The Managed Ventricular Pacing (MVP) mode has been shown to significantly reduce the percent ventricular pacing compared to the DDD/R mode. This study assessed the percent of ventricular pacing in a standard pacemaker population pro

This article outlines laboratory and full-scale studies on fire resistance of SCC. For this purpose 40 pre-stressed columns and 140 cylinders of concrete were subjected to compressive loading at high temperature. The SCC included water-binder ratios, w/b, between 0.40 and 0.70 and large amount limestone powder. Comparison was done with vibrated concrete, VC, with the same w/b. Mix proportions were

Background & Aims: The importance of genetic factors for the development of primary sclerosing cholangitis (PSC) is incompletely understood. This study assessed the risk of PSC and inflammatory bowel disease (IBD) among first-degree relatives of patients with PSC, compared with the first-degree relatives of a cohort without PSC. Methods: Subjects from the national Swedish cohort of PSC patient

Lazarillo, a glycoprotein involved in axon growth and guidance in the grasshopper embryo, is the only member of the lipocalin family that is attached to the cell surface by a GPI anchor. Recently, the study of Lazarillo homologous genes in Drosophila and mouse has revealed new functions in the regulation of lifespan, stress resistance and neurodegeneration. Here we report an analysis of biochemica

The current interest in organizational culture, identity, image and reputation and in organizational discourse points towards the pressure on contemporary organizations to focus attention on the symbolic dimensions of their activities. The phenomenon of branding, while originally portrayed as a marketing tool, can also be understood as an exercise in management of meaning. Branding does not only i