The present study reports the state of the art on the application of factors about prototyping engineering approach, using case studies of machinery manufactured by research centers of the Universidad Mayor de San Simon (UMSS) in Cochabamba-Bo-livia, to determine guidelines that allow structuring broad, analytical and intuitive prototyping strategies. The research centers linked to the case studie

Mixtures between choline and geranic acid (CAGE) have previously been shown to insert into lipid bilayers. This may be useful for the transdermal delivery of larger pharmaceuticals, however, little is known about the mechanism of activity. By comparing the interactions between CAGE and lipid bilayers with those of a less-active, yet closely-related analogue, choline octanoic acid (CAOT), a chemica

The creation of prototypes for the design of new products is a fundamental activity in the metal-mechanic sector that contributes to Bolivia's socioeconomic development. The existence of a multitude of factors that positively or negatively affect the prototype, are encompassed in two approaches: i) prototyping engineering and ii) prototyping management. Research for the design of prototypes suitab

Objective: To test if decreased parental protective behaviors, monitoring behaviors, and parental catastrophizing mediate relief of gastrointestinal symptoms in children 8–12 years with functional abdominal pain disorders (FAPDs). The study uses secondary data analyses of a randomized controlled trial in which exposure-based online cognitive behavioral therapy (ICBT) was found superior to treatmen

Kienböck's disease may result from a wrist-joint tamponade due to a mechanism similar to a compartment syndrome. An early drainage of the joint can probably prevent the necrosis of the lunate bone.

Background: Periodontitis and oral pathogenic bacteria can contribute to the development of rheumatoid arthritis (RA). A connection between serum antibodies to Porphyromonas gingivalis (P. gingivalis) and RA has been established, but data on saliva antibodies to P. gingivalis in RA are lacking. We evaluated antibodies to P. gingivalis in serum and saliva in two Swedish RA studies as well as their

Protein drugs, such as monoclonal antibodies, have proved successful in treating cancer and immune system diseases. The structural complexity of these molecules requires careful handling to ensure integrity and stability of the drug. In this study, a failure mode and effects analysis was performed based on a Gemba Walk method in a Swedish University Hospital. The Gemba Walk is focused on pharmacis

Nature-based solutions is a new trend in the area of urban and suburban planning. Thanks to its complex nature, Nature-based solutions provide multiple services on different levels of cities functionality. On the other hand nature-based solutions complexity requires extended knowledge in multiple engineering and societal areas, so the implementation is not straightforward. In recent years, countle

Non-typeable Haemophilus influenzae (NTHi) is a Gram-negative human pathogen that causes a wide range of airway diseases. NTHi has a plethora of mechanisms to colonize while evading the host immune system for the establishment of infection. We previously showed that the outer membrane protein P5 contributes to bacterial serum resistance by the recruitment of complement regulators. Here, we report

For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. Conventional dendritic cells type 1 (cDC1) are a rare population of professio

By applying the sociological concept of ‘emplacement’, this article analyses the creation of the ‘District of Mutual Respect’ in the old, neglected part of Wrocław (former German Breslau), a city which became Polish and lost its German population due to their forced migration after the Second World War. The District has in the last 20 years been transformed from slum to attractive environment and

Conditional independence is often used as a testable implication of causal models of random variables. In addition, equality constraints have been proposed to distinguish between data-generating mechanisms. We show that one can also find equality constraints in linear Hawkes processes, extending this theory to a class of continuous-time stochastic processes. This is done by proving that Hawkes pro

Background: Patients with heart failure and left bundle branch block (LBBB) may receive cardiac resynchronization therapy (CRT), but current selection criteria are imprecise, and many patients have limited treatment response. Hemodynamic forces (HDF) have been suggested as a marker for CRT response. The aim of this study was therefore to investigate left ventricular (LV) HDF as a predictive marker

Background: Despite advance in care of people with an ostomy, related complications remain prevalent. The objective of this study was to examine short- and long-term healthcare resource utilization and associated costs after ostomy creation. Methods: This observational study was based on retrospectively collected data from national and regional Swedish registries. The population consisted of peopl

Characterising the stop/start walking process of individuals in a crowded and congested space is an important consideration in modelling pedestrian movement. However, the reaction of pedestrians to speed changes, especially to the person in front, has not been fully characterised nor quantified for full adoption in computer models. This study, therefore, explored the different phases of the stop/s

Global climate change has increasing effects on mental health and well-being (e.g., in the form of climate anxiety), both through direct exposure to its consequences (e.g., extreme weather) and through indirect exposure (i.e., the social representation or appraisal of climate change without direct contact to its physical consequences). To help people cope with distress due to climate anxiety, natu

Global climate change has increasing detrimental effects on mental health (e.g., in the form of climate anxiety), both through direct exposure to its consequences (e.g., extreme weather) and through indirect exposure (i.e., the social representation of climate change without direct contact to its physical consequences). To help people cope with the anxious response, nature connectedness is suggest