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Surveillance after resection of pancreatic ductal adenocarcinoma : How to do it and what are the benefits?

Background and objective: Surveillance following resection with curative intent of pancreatic cancer varies widely, and supporting evidence is limited. Recurrence is although frequent, not at least during the first 2 years. Surveillance may be costly, but evidence on how this influences overall survival is not fully elucidated. Methods, Results: There are reports implying that signs of biological

Single Junction and Tandem Junction Nanowire Solar Cells

Solar cells based on silicon are successfully harvesting solar energy in established and increasingly widespread solar panels. However, their efficiency is limited by the Shockley–Queisser limit. For certain applications where high efficiency is the key figure of merit, the use of multi-junction solar cells is desirable.III–V multi-junction solar cells exhibit the highest efficiencies achieved to

Picking the Goodies When Sleuthing Online

Online activities can serve as tools for criminal opportunities and arenas for victimhood, but they can also function as reality constructions embedded in social control. One example of the latter is online sleuthing, primarily focused on dramatizing and disentangling offline crimes. This article relies on data from an ethnographic project conducted on the Swedish platform Flashback and analyzes p

Family Genetic-Risk Profiles Associated With Divorce

We used Swedish national-register data (N = 2,828,777) to examine divorce and its associated patterns of family genetic-risk scores (FGRSs; personalized measures of genetic risk inferred from diagnoses in relatives) across 10 psychiatric disorders: major depression, anxiety disorders, obsessive compulsive disorder, bipolar disorder, schizophrenia, anorexia nervosa, alcohol use disorder, drug use d

Carbon Footprints in a Global Marketplace : Firm-Level Insights on Trade and the Environment

This doctoral thesis consists of three independent research papers. All papers are empirical and cover the area of international trade and environmental economics, with particular focus on Swedish manufacturing firms. The first paper investigates how carbon offshoring could contribute to cleaner production. Using Swedish firm-product level data from 2005-2014, combined with instrumental variable a

A study of size-selective renal elimination using a novel human model

The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C,

Estimating Heterogeneous Panel Data Models

This thesis deals with the development and application of new estimation methods of heterogenous panel data models. In Paper I, a new estimator for heterogeneous panel data models with random interactive effects is proposed. The heterogeneity in this paper is viewed as heterogeneity over time, which is modeled by having the slope coefficients exhibit multiple structural breaks. The suggested estim

Changes in educational inequalities in knee and hip osteoarthritis surgery and non-surgery specialist care visits over time in Sweden

ObjectiveTo examine changes in prevalence and socioeconomic inequalities in knee and hip OA outcomes, in more specific surgery and non-surgery specialist care visits, from 2001 to 2011 in Sweden and to what extent sociodemographic factors can explain the changes.DesignWe included all individuals aged ≥35 years resident in Sweden from 2001 to 2011. Individual-level data was retrieved from the Swedi

Peter Weiss : The Black Wells

Short presentation of Swedish-German filmmaker Peter Weiss (1916 - 1982) and his films in connection with a new streaming service from the Filmform foundation

Nucleoredoxin Redox Interactions Are Sensitized by Aging and Potentiated by Chronic Alcohol Consumption in the Mouse Liver

Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen species and regulates key cellular processes through redox protein–pr

Development and prognostic validation of a three-level NHG-like deep learning-based model for histological grading of breast cancer

Background: Histological grade is a well-known prognostic factor that is routinely assessed in breast tumours. However, manual assessment of Nottingham Histological Grade (NHG) has high inter-assessor and inter-laboratory variability, causing uncertainty in grade assignments. To address this challenge, we developed and validated a three-level NHG-like deep learning-based histological grade model (

Airborne SARS-CoV2 virus exposure, interpersonal distance, face mask and perceived risk of infection

Participants judged the risk of an infection during a face to face conversation at different interpersonal distances from a SARS-CoV-2 infected person who wore a face mask or not, and in the same questionnaire answered questions about Corona related issues. Keeping a distance to an infected person serves as a protective measure against an infection. When an infected person moves closer, risk of in

Geochemical and thermodynamic constraints on Archean comagmatic volcanic and cumulate rocks from southern West Greenland

The extensive exposure of the Archean continental crust in southern West Greenland makes it an important window into the tectonic evolution of early Earth. Here, we provide a comprehensive geochemical data set for tholeiitic amphibolites (meta-basalts), calc-alkaline leucoamphibolites (meta-andesites), and ultramafic rocks (meta-cumulates) for the Mesoarchean Bjørneøen Supracrustal Belt, Nuuk regi

What To Do About Conspiracy Theories? : Academic Entanglements in Conflicts Over Truths

Increasingly social activists, journalists and policy makers have expressed concern over the proliferation of conspiracy theories in the public space. There is a growing fear of their impact on social cohesion and democracy, their power to erode trust in state institutions and science. These concerns often come with an expectation that it is the responsibility of academics to engage with conspirac

Identification of New Ketamine Metabolites and Their Detailed Distribution in the Mammalian Brain

Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar

Global longitudinal strain in long-term risk prediction after acute coronary syndrome : an investigation of added prognostic value to ejection fraction

Aims: This study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS). Method and results: This retrospective study included patients admitted with ACS between 2008 and 2014 from the three participa

Manifestations of X-linked pyruvate dehydrogenase complex deficiency in female PDHA1 carriers

Background and purpose: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X-linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1-related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii) delineate the associated phenotype. Methods: In a natio

The Atomic Future : Technology, Labor and World Peace in the Thought of ʿAli Rashid Shaʿath

In 1946, one year after the atomic bombings of Japan, Palestinian thinker ʿAli Rashid Shaʿath (1908–1967) published a book entitled Min al-binsilin ila al-qunbula al-zarriya (From Penicillin to the Atomic Bomb). An accessible work of popular science, it con- tains highly optimistic reflections on the future and predicts the following two events as a result of nuclear technology and energy: a worke