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Background: KIT mutations are the predominant driver mutations in gastrointestinal stromal tumors (GISTs), and targeted therapy against KIT has improved treatment outcome dramatically. However, gaining secondary mutation of KIT confers drug resistance of GISTs leading to treatment failure. Results: In this study, we found that secondary mutation of KIT dramatically increases the ligand-independent

Coronautbrottet är ett hot mot Sveriges nationella säkerhet. Det riskerar leda till en ökning av främmande makters aktiviteter, terrorattacker, organiserad brottslighet samt social oro, skriver Ardavan Khoshnood, specialistläkare, kriminolog och statsvetare.The corona eruption is a threat to Sweden's national security. It risks leading to an increase in the activities of foreign powers, terrorist attacks, organized crime and social unrest, writes Ardavan Khoshnood, specialist physician, criminologist and political scientist.

In my dissertation the method to describe semantic change used in the Swedish Academy dictionary (SAOB) is compared with cognitive semantic models of such a change. The work of SAOB is theoretically unbound in terms of overarching semantic theories, and the methods of describing word meaning and semantic change in the dictionary are rather developed for pragmatic reasons (such as consistency and e

Sustainability philosophers claim that we are at an impasse of stories, finding ourselves in a blank chapter between the old and the new. The old story, characterized by separation, technological dominance and human superiority over nature, is unfolding in an ecological crisis giving space for a new narrative defined by inter-being, cooperation and balance. It has been put forward that this crisis

Nature-based adaptation planning is a challenging endeavor, not least because it requires transdisciplinary approaches to unite different actors' efforts and capacities. However, empirical knowledge on associated governance processes is scarce and fragmented. Against this background, this paper examines the integration of nature-based approaches for climate change adaptation into municipalities’ d

Municipal advisory committees are becoming increasingly influential in guiding decision-making processes that address climatic issues. According to the Adaptigation Institutionalization Framework (included in the recent IPCC report), the implementation of such participatory structures is vital for the effective, joint institutionalization of climate change mitigation and adaptation. However, there

The efficiency approach of moving towardssustainable consumption throughmainlytechnological solutions, which dominatesenvironmental policymaking, has overallfailed to reduce the adverse environmental impacts caused by unsustainable consumption patterns. Increasingly, it is recognized that efficiency needs to be coupled with sufficiency, which aims to reduce the absolute levels of consumption. Whil