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Severe conditions and lack of cure for many amyloid diseases make it highly desired to understand the underlying principles of formation of fibrillar aggregates (amyloid). Here, amyloid formation from peptides was studied using Monte Carlo simulations. Systems of 20, 50, 100, 200 or 500 hexapeptides were simulated. Association kinetics were modeled equal for fibrillar and other (inter- and intra-p

Recent work has uncovered a role of the microRNA (miRNA) miR-29 in remodeling of the extracellular matrix. Partial bladder outlet obstruction is a prevalent condition in older men with prostate enlargement that leads to matrix synthesis in the lower urinary tract and increases bladder stiffness. Here we tested the hypothesis that miR-29 is repressed in the bladder in outlet obstruction and that th

Effects of land use changes are starting to be included in estimates of life-cycle greenhouse gas (GHG) emissions, so-called carbon footprints (CFs), from food production. Their omission can lead to serious underestimates, particularly for meat. Here we estimate emissions from the conversion of forest to pasture in the Legal Amazon Region (LAR) of Brazil and present a model to distribute the emiss

Antibiotics are frequently administered orally to treat bacterial infections not necessarily related to the gastrointestinal system. This has adverse effects on the commensal gut microbial community, as it disrupts the intricate balance between specific bacterial groups within this ecosystem, potentially leading to dysbiosis. We hypothesized that modulation of community composition and function in

Abstract in German Dieser zweite im Rahmen des Forschungsprojekts „Folk Terminology and Musical Phenomena“ unter dem Überbegriff „European Voices“ von Ardian Ahmedaja herausgegebene Band verschreibt sich im Kern der Frage nach den unterschiedlichen Denotationen und Konnotationen vokaler Mehrstimmigkeit in Europa.

Understanding the uncertainty of climate models in space and time is necessary to help water resources managers and hydrologists in the selection of appropriate model for a specific application. In this paper, we use three separate methods to evaluate and compare the utility of 14 climate models for seven basins with area range of 2,656–26,355 km2 on the South Korean Peninsula. On the one hand, th

The ambition underlying this study is to provide a valid and efficient screening tool targeting accessibility problems in the ordinary housing stock. The study aims to test the feasibility and interrater agreement of a screening-tool version of the Housing Enabler in a real estate company practice context. Two rater pairs administer the screening in 35 apartments in a Swedish municipality. The ove

Rättssociologen Stefan Larsson tecknar vad han kallar en tankekarta runt beslutsprocesser och frågan om vem som bestämmer om vindkraften och på vilken kunskapsgrund detta görs. När det gäller beslutshierarkier beskriver Stefan Larsson vindkraftsutbyggnaden som en naturlig konflikt mellan nationella och lokala perspektiv, men menar att det är just kunskapstyperna som missas i debatten. Det är nämli

‘Nordic noir’ has increasingly become the prevalent term in the English-speaking world when referring to contemporary crime fiction – books, television serials and feature films – from the Nordic countries. With its unexpected international appeal and unforeseen longevity, the phenomenon has been the subject of, for instance, popular guide books and television documentaries for international audie

Background: An optimal dosage and infusion regime for protamine reversal of heparin after cardiopulmonary bypass is important. Methods: Protamine dosages of either 2mg/kg or 4mg/kg bodyweight were compared in 40 patients after first time coronary arterial bypass grafting. Protamine was infused with a syringe driver over 20 minutes. Arterial blood sampling was performed prior to and during surgery

Soil biological studies are often conducted on sieved soils without the presence of plants. However, soil fungi build delicate mycelial networks, often symbiotically associated with plant roots (mycorrhizal fungi). We hypothesized that as a result of sieving and incubating without plants, the total fungal biomass decreases. To test this, we conducted three incubation experiments. We expected total

Background Rheumatoid arthritis (RA) and osteoarthritis (OA) are important musculoskeletal diseases that the EUMUSC.NET project developed Standards of Care (SOC) for. Objective The purpose was to explore factors to enable successful implementation of the SOC for RA and OA. Methods A combined set of methods was used; a literature search, a European survey among patients, clinicians and policymakers

Access to second-line antiretroviral therapy (ART) for HIV-positive patients remains limited in sub-Saharan Africa. Furthermore, outcomes of second-line ART may be compromised by mortality and loss to follow-up (LTFU).

Energy-dispersive X-ray fluorescence (EDXRF) spectrometry is not adequate for the determination of some potentially hazardous trace elements, such as Cd, Cu, Ni and Pb at low concentration in PM2.5 atmospheric aerosol particles. Therefore, a method has been developed for the determination of these elements in atmospheric aerosol particles using high-resolution continuum source graphite furnace ato

Whilst innate B1-B cells are atheroprotective, adaptive B2-B cells are considered pro-atherogenic. Different subsets of B regulatory cells (B-reg) have been described. In experimental arthritis and lupus-like disease, B-reg are contained within the CD21(hi)CD23(hi)CD24(hi) B cell pool The existence and role of B-reg in vascular disease is not known. We sought to investigate the existence, identity

Popular Abstract in Swedish Patienter som drabbats av Parkinsons sjukdom (PD) saknar förmågan att medvetet kontrollera sina rörelser. Livslång medicinering krävs, vilket lindrar symptomen och leder till att rörelsemönstret förbättras, men med varierad effektivitet. Trots att de läkemedel (t ex L-DOPA) som finns tillgängliga idag har fantastisk effekt, minskar deras effektivitet i takt med att sjukParkinson’s disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. The cause of these motor symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). These neurons project axons to the striatum where they release dopamine, a neurotransm

Popular Abstract in Swedish De senaste årtiondena har det diskuteras om det finns anledning till oro när det gäller mannens reproduktionsfunktion. Vissa forskningsresultat tyder på att spermieantalet har minskat och fler män har diagnostiserats med testikelcancer och medfödda missbildningar av könsorganen än tidigare. Om detta beror på genetiska faktorer, livsstil eller miljöfaktorer, eller alla tAndrogens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. Prostate specific antigen (PSA) is a downstream target and is commonly used in the screening of prostate cancer. The relationship between CAG number and mal