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Clinical characteristics.Spinocerebellar ataxia type 4 (SCA4) is a progressive neurologic disease characterized by cerebellar involvement (gait ataxia, balance disturbances, eye movement abnormalities), brain stem involvement (dysarthria, dysphagia), sensory neuropathy, motor neuron involvement (muscle wasting and spasticity), autonomic dysfunction (especially orthostatic hypotension), and cogniti

The finite element (FE) method is one of the approaches available for solving different types of partial differential equations in the various fields of physics, such as solid mechanics, heat transfer, and electromagnetics. Visualization and manipulation of results play a crucial role in the interpretation and analysis of simulation results, especially when complex and advanced problems are consid

Data-driven mechanics offers great potential in engineering applications, where the efficient simulation of complex and, in particular, path-dependent material behavior is often challenging. Within this approach, conventional material models are replaced by data sets containing snapshots of stress, strain and the history of both assumed to be sufficiently accurate representations of the underlying

An elderly, right-handed, male patient presented to the emergency department at a middle sized hospital with a few hours' history of mild confusion and a difficulty expressing himself verbally. Past medical history consisted of hypertension and cured hairy cell leukemia. CT scan of the brain showed a 5 cm infarction in the left occipital lobe, and a corresponding P2 occlusion was seen. The patient

I dagens samhälle kan människor med sårbarhetsfaktorer, såsom ålderdom eller respiratoriska sjukdomar, riskera att dö när de utsätts för virusinfektioner. Det figurerar ständigt olika influensavarianter bland oss som vissa kan tillfriskna från utan några mediciner, men de individer som har en uttalade sårbarhet behöver antivirala läkemedel för att bekämpa viruset. Ett av dessa läkemedel är ZanamivIn this study, a novel route to synthesising Zanamivir have been accomplished. In the past two decades, many scientists have struggled to find a green and step-economical route to synthesising Zanamivir. None have succeeded to insert guanidine; thus, relying on amination and reduction with explosive azido reagents, causing the synthesis to be far too long and hazardous. Our aim was to shorten the

In manufacturing, thermomechanical processes such as static annealing and hot working are commonly used to tailor the microstructure of metals to achieve favourable macroscopic material properties that meet specific application requirements. To improve sequential manufacturing processes and to accurately predict the microstructural changes of the material along the process chain, physically motiva

The solution of coupled multi-field problems by means of commercially available finite element codes such as Abaqus constitutes an important part in the study of industrial processes. Against this background, a comprehensive implementation framework for a gradient-enhanced continuum damage formulation in a thermo-mechanically coupled finite deformation setting is proposed in this contribution. To

Professional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backstaProfessional Emotions in Court examines the paramount role of emotions in the legal professions and in the functioning of the democratic judicial system. Based on extensive interview and observation data in Sweden, the authors highlight the silenced background emotions and the tacitly habituated emotion management in the daily work at courts and prosecution offices. Following participants ‘backsta

The free and open source software tool ADAPT (A Diversely Applicable Parameter Identification Tool) for the inverse parameter identification of constitutive material models is presented and applied in combination with Finite Element (FE) simulations. Different types of input data, namely integral data such as forces and field data such as displacement and strain fields, are considered within a mul

How travellers perceive the quality of public transport services has profound influence on their satisfaction and thus of their inclination to choose this mode of transport. Punctuality, which may be interpreted as timetable adherence or overall travel time predictability, is often pointed out as the most important constituent of overall service reliability of public transport systems. However, in

The railway transport system has seen an increasing demand in recent years, while delays and missed punctuality goals continue to be problems in many countries. To improve punctuality, the amount of primary delays needs to be decreased, and knowledge of the shares of the different types of delay – entry, run, and dwell – is important to identify the most efficient countermeasures. This paper inves

The timing of the spring season in the boreal region is shifting under global warming, with profound impacts on ecosystems and hydrological processes. However, the mechanisms driving this transition and its considerable interannual variability are not well described, especially regarding the influence of large-scale atmospheric teleconnection patterns. This study examines the temporal variability

This study examines the long-term socioeconomic impacts of 44 train station openings between 1995 and 2015 across Swedish regions. Using the conditional difference-in-differences estimator developed by Callaway and Sant'Anna (2021), which accounts for variation in treatment effects across time and locations, we evaluate the impact on population, income, education, and unemployment. Twenty years af

This chapter explores performances of emotion regulation through a dramaturgical lens, focusing on occupations with high performative demands. While reviewing research and theorizing on performance, we point to key intersections between sociological studies on emotion management and psychological studies on emotion regulation. First, we focus on the scaffolding of performance, how the script and t

Access is the process of establishing rapport with a field containing different phases without an articulated end. Qualitative research often involves studying people in their social setting, documenting action, and meaning making in relation to the field in which it occurs through ethnographic methods such as observations, shadowing, and interviews. Gaining permission to a site or a specific grou

Data-driven methods provide great potential for future applications in engineering, for example in terms of more efficient simulations. Conventional material models and the associated constitutive equations are substituted by a minimization of a distance between so-called material and mechanical states, which, however, leads to non-unique solutions. The aim of this paper is to analyze the influenc