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Since 2014, Sweden has pursued the world's first Feminist Foreign Policy (FFP). However, the effectiveness of its policy promotion depends on how Sweden's efforts to spread this norm-based policy are perceived and evaluated by other states. We argue that a policy promotion effort has to be perceived as legitimate, coherent and salient by target populations in order to be effective. We investigate
Desire for life and protecting lives has come to the fore during the pandemic. Borders have been closed to stop the spread of Covid-19. The virus does not respect borders, yet physical distance is crucial. Three things have become clear. One is the level of uncertainty about which measures are most efficient. The other is that the neo-liberal philosophy with “just in time” deliveries on a global m
Biliary tract cancers (BTC) are rare and often diagnosed in late stages with advanced, nonresectable disease. The targeted agents panitumumab and bevacizumab have shown promising outcomes in combination with chemotherapy in other gastrointestinal (GI) cancers. We wanted to investigate if panitumumab or bevacizumab was the most promising drug to add to chemotherapy. Eighty-eight patients were rando
Chronic pancreatitis (CP) should be suspected in the case of recurrent upper abdominal pain of unknown origin and/or clinical signs of exocrine pancreatic insufficiency (EPI). Alcohol is the most common etiological factor associated with CP, others being smoking, male gender, and hereditary forms. CP is often associated with recurrent episodes of acute exacerbations. As of today, there is no accep
BACKGROUND: There is a lack of evidence-based recommendations for the age at which women with a family history of cancers other than breast cancer should start breast cancer screening. METHODS: Using Swedish family cancer data sets, the authors conducted a nationwide cohort study including 5,099,172 Swedish women born after 1931 (follow-up, 1958-2015). Accounting for calendar time, they calculated
Gut-associated lymphoid tissues (GALTs) comprise key intestinal immune inductive sites, including the Peyer’s patches of the small intestine and different types of isolated lymphoid follicle (ILF) found along the length of the gut. Our understanding of human GALT is limited due to a lack of protocols for their isolation. Here we describe a technique that, uniquely among intestinal cell isolation p
Objectives Despite the limited invasiveness of endoscopic transsphenoidal surgery (ETSS), some degree of nasal structure destruction is unavoidable. Our objective was to evaluate sinonasal morbidity and self-reported health before and 6 months after ETSS for pituitary tumors, and to identify possible predictive factors for deterioration in sinonasal health. Design Prospective observational cohort
Recent qualitative and quantitative research on the interrelationships between innovation, job quality and employment shows a strong association between job quality and product, process, and to a lesser extent organizational innovation. This is theorized as the interaction of two systems – job quality and innovation systems. Increased employment and improved job quality are found to result from inRecent qualitative and quantitative research on the interrelationships between innovation, job quality and employment shows a strong association between job quality and product, process, and to a lesser extent organizational innovation. This is theorized as the interaction of two systems – job quality and innovation systems. Increased employment and improved job quality are found to result from in
Context. Observations of the Galactic bulge suggest that the disk formed through secular evolution rather than gas dissipation and/or mergers, as previously believed. This would imply very similar chemistry in the disk and bulge. Some elements, such as the α-elements, are well studied in the bulge, but others like the neutron-capture elements are much less well explored. Stellar mass and metallici
Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the polymer level, a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. Here, we present the first crystal structure of the catalytic domains of DS-epi1, solved at 2.4 Å resolution, as well as a model of the full-length luminal protein obtained by a combinati
We report a new design of an acoustophoretic trapping device with significantly increased capacity and throughput, compared to current commercial acoustic trapping systems. Acoustic trapping enables nanoparticle and extracellular vesicle (EV) enrichment without ultracentrifugation. Current commercial acoustic trapping technology uses an acoustic single-node resonance and typically operates at flow
Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2
The dynein motor protein transports proteins away from the cell membrane along the microtubule network. Recently, we found the microtubule network was important for regulating the membrane abundance of voltage-gated Kv7.4 potassium channels in vascular smooth muscle. Here, we aimed to investigate the influence of dynein on the microtubule-dependent internalization of the Kv7.4 channel. Patch-clamp
