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Physiochemical degradation of therapeutic proteins in vivo during plasma circulation after administration can have a detrimental effect on their efficacy and safety profile. During drug product development, in vivo animal studies are necessary to explore in vivo protein behaviour. However, these studies are very demanding and expensive, and the industry is working to decrease the number of in vivo

Research on what makes people walk/cycle for tourism is significantly understudied in relation to smart app use among Asians. To bridge this gap, this work proposes and verifies an integrated research framework that includes environment and health factors, along with heavy versus non-heavy users of smart apps based on PLS-SEM and fsQCA. Public health has a positively significant impact on behavior

This research evaluates the impacts of flexible demand-side management on electricity load and indoor thermal comfort under extreme weather conditions, focusing on elderly people. For this purpose, an elderly care center in Alesund, Norway is chosen as the pilot building. A high spatiotemporal resolution building energy model is developed including thermal zones and energy systems, verified agains

The present study aimed to compare men and women with gambling disorder (GD) regarding presence of psychiatric comorbidity and socio-economic vulnerability, and to examine whether these factors appear before or after the gambling disorder. This is a retrospective case-control study, based on registers from The National Board of Health and Welfare and Statistics Sweden. A total of 3592 adults with

Diachronic and synchronic studies of linguistic landscapes of central streets and markets were conducted in five cities in Ukraine with different language use preferences in 2015 and 2017–19. The relationship between a monolingual state language policy and the reality of language use in public spaces was investigated. This study focuses on the dynamics of the linguistic landscape of Odesa, a Russi

We presented a study of charge-independent (CI) and charge-dependent (CD) two-particle differential number correlation functions R2 and transverse momentum correlation functions P2 in pp collisions at s=2.76 TeV with the PYTHIA and HERWIG models.Calculations were presented for unidentified hadrons in three pT ranges 0.2 < pT≤ 2.0 GeV/c, 2.0 < pT≤ 5.0 GeV/c, and 5.0 < pT≤ 30.0

The energy deposited at very forward rapidities (very forward energy) is a powerful tool for characterising proton fragmentation in pp and p-Pb collisions. The correlation of very forward energy with particle production at midrapidity provides direct insights into the initial stages and the subsequent evolution of the collision. Furthermore, the correlation with the production of particles with la

A significant amount of embodied energy, materials, and economic capital is tied to vacant and underused buildings. Sharing is an effective way to reduce the excess use of space. Beside sharing, much more focus should be placed on maximizing the functional use of existing buildings. Adaptive reuse can be effective not only in mitigating obsolescence, but also in enhancing the vitality of site surr

Passenger journeys increasingly include mediality in its various manifestations. Mass-transit systems need clear signs, often featured in the form of audiovisual media, and transmitted through displays working for captive and in-transit audiences. With reference to Italian biggest railway stations, the chapter explores the reconfiguration of those television-like networks (commonly known as ‘go-tv

From a radiation protection point of view, nuclear medicine is a complex medical specialty that includes both radionuclide and radiopharmaceutical production and patient diagnostics and therapy. The practical work with radiation sources includes a variety of procedures, activity levels, dose rates, and risks of contamination. The radiation dose to the worker is largely determined by the knowledge

A search for the Higgs boson decaying into a pair of charm quarks is presented. The analysis uses proton–proton collisions to target the production of a Higgs boson in association with a leptonically decaying W or Z boson. The dataset delivered by the LHC at a centre-of-mass energy of [InlineEquation not available: see fulltext.] and recorded by the ATLAS detector corresponds to an integrated lumi

Knowledge in statistics is essential to draw solid conclusions from data. This chapter covers the basic concepts needed to navigate in the world of biostatistics, with the aim that the reader should know what to search for when encountering new situations. First, the chapter introduces basic concepts such as scales of measurement, relation between sample and population, and features of stochastic

The use of ionizing radiation and radioactive substances for diagnostic, interventional and therapeutic procedures in health care provides benefits to millions of people each year. Since ionizing radiation also has harmful effects, a radiation protection approach is needed. The International Commission on Radiological Protection (ICRP) has formulated the primary aim of radiation protection in gene

Diagnostic nuclear medicine, more recently also named functional molecular imaging, deals with medical procedures performed to help diagnose a variety of diseases. The procedures are based on the use of tracer amounts of radioactive material, where a radionuclide is attached to a ligand with specific affinity to a physiological, metabolic, or receptor-specific process. To balance the benefit of a

Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It al

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), le

To improve film cooling effectiveness of a gas turbine blade, a kind of plasma ac-tuator is introduced on the blade surface. The effect of three arrangements of plasma actuators on flow characteristics and film cooling performance is numer-ically investigated by a verified turbulence model. Results show that the coolant air under plasma is pulled down to the wall, and the near-wall air is sped up

This chapter is an attempt to rectify one of the main shortfalls of the constitutive approach of communication (CCO): the absence of neoliberal capitalism in its conception of both communication and organizations. Any theory of the social must at least consider the current social order at hand, which we refer to as neoliberal capitalism. Building on the theoretical premise that communication is a