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Putative biomarkers of gemcitabine response have been extensively studied in pancreatic cancer, but less so in other types of periampullary adenocarcinoma. The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response. The RNA-binding protein human antigen R (HuR) has been demonstr

The function of the immune system requires coordinated expression and action of many genes and proteins. With the emergence of high throughput technologies it has become possible to target human immunity from a systems biology point of view. To perform systems biology studies with comparable results we need not just a reference gene and protein set but also useful and descriptive reference categor

A review of tissue diagnostics using laser-induced fluorescence is given with illustrations chosen from work performed by the Lund group. Two major topics are considered: the demarcation of malignant tumors from normal surrounding tissue and the identification of atherosclerotic regions in arteries. Specific fluorescence from injected agents as well as tissue natural autofluorescence is discussed.

Compression was earlier an important and well-managed part of the clinical routine, but during the past 15-20 y the use has diminished, except for mammography, where it is a prerequisite for having images of high quality and low radiation dose. According to national and European regulations and recommendations, it is important to apply the compression technique to obtain the optimal image quality

Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal condition characterised by increased body temperature and muscle rigidity in a patient receiving antipsychotic treatment. Diagnosis also requires the presence of two symptoms of autonomic dysfunction and/or leukocytosis and increased creatin kinase. All neuroleptics, including atypical agents, can cause the condition, which is th

Kulturartikel om konkurrensen mellan olika amerikanska filmbolag som satsar på animerad film med hjälp av datorteknik.

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Neural stem cells (NSCs) derived from human fetal striatum and transplanted as neurospheres survive in stroke-damaged striatum, migrate from the implantation site, and differentiate into mature neurons. Here, we investigated how various steps of neurogenesis are affected by intrastriatal transplantation of human NSCs at different time points after stroke and with different numbers of cells in each

Purpose: To investigate the retinal structure and function during the progression of X-linked retinoschisis (XLRS) from childhood to adulthood. Methods: Ten patients clinically diagnosed with XLRS were investigated at 6-15 years of age (mean age 9 years) with a follow-up 8 to 14 years later (mean 12 years). The patients underwent regular ophthalmic examination as well as testing of best corrected