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Cystic fibrosis-related diabetes (CFRD) is a common complication for patients with cystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR). The cause of CFRD is unclear, but a commonly observed reduction in first-phase insulin secretion suggests defects at the beta cell level. Here we aimed to examine beta- and alpha-cell function in th
AbstractThis essay focuses on teachers' perspective on student engagement and aims to highlight the connection between student engagement, teaching and content matter. It investigates how teachers interpret the concept of student engagement and what consequences their interpretation have for themselves, their teaching and their students. It also examines how teachers perceive the relationship betw
The resource curse literature underscores the fact that extractive economies face challenges in diversifying their economies. What is less explored are the public finance challenges encountered in these economies when the extractive industries are completely privatized. Using a recently compiled dataset on public revenues, expenditures and debt, this paper explores the nexus between the privatized
We now know that state formation experiences outside Europe were not merely attenuated or failed versions of the European experiences (Herbst, 2000; Hoffman, 2015; Johnson and Koyama, 2016). The diverse paths taken towards the modern state imply that existing knowledge on state formation processes can be enhanced by integrating the experiences of Africa and other developing regions. This dissertat
BACKGROUND: Organs from older donors are increasingly used in lung transplantation, and studies have demonstrated that this could be safe in selected recipients. However, which recipient groups that have the largest benefit of older organs are unclear. This multicenter study reviews all bilateral lung transplantations (BLTx) from donors 55 years or older stratified by recipient diagnosis and compa
The evolution of genetic barriers opposing interspecific gene flow is key to the origin of new species. Drawing from information on over 400 admixed genomes sourced from replicate transects across the European hybrid zone between all-black carrion crows and grey-coated hooded crows, we decipher the interplay between phenotypic divergence and selection at the molecular level. Over 68% of plumage va
The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic enrichment i
OBJECTIVE To estimate the causal association between intake of dairy products and incident type 2 diabetes. RESEARCH DESIGN AND METHODS The analysis included 21,820 European individuals (9,686 diabetes cases) of the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study. Participants were genotyped, a
This report is an inventory of the state of knowledge of ethical, social, and legal challenges related to artificial intelligence conducted within the Swedish Vinnova-funded project “Hållbar AI – AI Ethics and Sustainability”, led by Anna Felländer. Based on a review and mapping of reports and studies, a quantitative and bibliometric analysis, and in-depth analyses of the health care sector, the tThis report is an inventory of the state of knowledge of ethical, social, and legal challenges related to artificial intelligence conducted within the Swedish Vinnova-funded project “Hållbar AI – AI Ethics and Sustainability”, led by Anna Felländer. Based on a review and mapping of reports and studies, a quantitative and bibliometric analysis, and in-depth analyses of the healt- care sector, the t
DEBATT Den snabba utvecklingen inom artificiell intelligens ger stora utmaningar, vilket kan skada tilliten till AI, skriver fyra forskare. I en nyligen publicerad rapport har de presenterat såväl problemområden som förslag till lösningar.
