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Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today - conventional X-ray crystallography - is that it only provides structural infor
Although fathers experience emotional stress both during the care period and after discharge, there is limited research focusing exclusively on fathers’ experiences after their time in a neonatal intensive care unit. Their experiences are important for tailoring support to fathers based on their individual needs. This paper is part of a longitudinal study in which parents were followed by means of
Introduction Management of testicular torsion varies between specialties resulting in lack of standardization. The aim of this survey was to assess pre-, peri-, and postoperative differences. Methods An online questionnaire was distributed in 2023 to general and pediatric surgeons, pediatric urologists, and urologists by the Trainees of European Pediatric Surgery. Main Results Among 88 respondents
In this, the tenth annual update for the F1000Research Tics collection, we summarize research reports from 2023 on Gilles de la Tourette syndrome and other tic disorders. The authors welcome article suggestions and thoughtful feedback from readers.
Background: The detrimental impacts of adverse childhood experiences (ACEs) on health have been extensively studied, mainly focusing on the effects of ACEs on adults. However, there is a dearth of studies exploring their influences on adolescents. Objective: This study aims to investigate the associations between ACEs and psychological distress among Swedish adolescents. Participants and setting:
The European spruce bark beetle is a major disturbance agent in Norway spruce forests in Europe, and with a changing climate it is predicted that damage will increase. To prevent the bark beetle population buildup, and to limit further spread during outbreaks, it is crucial to detect attacked trees early. In this study, we utilize Sentinel-2 data in combination with a risk map, created from geodat
Introduction: The scapular osseous free flap (SOFF) is being increasingly used for complex head and neck reconstructions. This study examined the surgical outcomes, focusing on post-operative complications and sequelae in patients who underwent SOFF for maxillary and mandibular reconstructions. Material and Methods: This retrospective, observational, population-based study included patients who un
In this study, wireless embedded relative humidity, RH, probes, developed by Electrotech Kalix AB, were evaluated in a laboratory setting. These RH-probes are designed to monitor the drying of concrete at construction sites in a Swedish climate. Two concrete slabs, each with a thickness of 100 mm, were fabricated, using two different concrete mixes, with water-to-cement (w/c) ratios of 0.6 and 0.4
This paper discusses the role of different factors determining the linguistic competence of heritage speakers (HSs) based on examples from speakers who speak a Romance language (French, Italian, Portuguese, or Spanish) as heritage language (HL) and German as the environmental language. Since the relative amount of contact with the HL and the environmental language may vary during the acquisition p
BACKGROUND: Experimental research has shown the benefits of auditory white noise on cognitive performance in children with attention problems. However, little is currently known about individual differences in noise response amongst children with a clinical diagnosis of attention deficit hyperactivity disorder (ADHD). In addition, no research has so far tested the effects of visual white noise on
In this paper, we argue that e-participation research is at a crossroads as its theories and empirical scope are increasingly detached from the contemporary relationship between information technology and political participation. We illustrate this challenge through two developments: (1) the dissolving boundaries between online and offline spheres of political participation and (2) the growing disIn this paper, we argue that e-participation research is at a crossroads as its theories and empirical scope are increasingly detached from the contemporary relationship between information technology and political participation. We illustrate this challenge through two developments: (1) the dissolving boundaries between online and offline spheres of political participation and (2) the growing dis
The reuse and reappropriation of audiovisual content have been a recurring topic of research in the humanities, not least in studies of remix cultures. An open question that remains, however, is how artificial intelligence and machine learning may help scholars study the reuse of audiovisual heritage. In this article, we introduce the Video Reuse Detector (VRD) – a methodological toolkit for identThe reuse and reappropriation of audiovisual content have been a recurring topic of research in the humanities, not least in studies of remix cultures. An open question that remains, however, is how artificial intelligence and machine learning may help scholars study the reuse of audiovisual heritage. In this article, we introduce the Video Reuse Detector (VRD) – a methodological toolkit for ident
We present a novel approach to the 3D sound source localization task for distributed ad-hoc microphone arrays by formulating it as a set-to-set regression problem. By training a multi-modal masked autoencoder model that operates on audio recordings and microphone coordinates, we show that such a formulation allows for accurate localization of the sound source, by reconstructing coordinates masked
Publikation i serien Rapporter om utbildning om hur filmundervisning kan användas i skolan med västern- och skräckfilmsgenrerna som exempel.
Libraries have been pinpointed as a possible hub for information and safety during a crisis. We present a workshop design to contribute to the education of librarians with the goal to make them more able to provide inclusive and accessible information in a crisis. The workshop was carried out during a conference for librarians. The results from the workshop indicate that there is a need for furthe
Adults can extract phonological regularities from just several minutes’ exposure to natural-istic input of an unknown spoken language (Gullberg et al., 2010). We examined whether such implicit statistical learning mechanisms also operate in the sign language modality. The input materials con-sisted of a continuous sign stream in the form of a weather forecast in Svenskt Teckenspråk (STS). L1-speak
Stadsodling kan fungera som ett inslag i en stadsbyggnadskonst där vi förvaltar odlingsbar mark och människors relationer till platser på ett hållbart sätt. I föreliggande studie undersöktes möjligheten för odlingsverksamheter med barn att bidra till deras naturkontakt, lek och lärande. Odlingarnas bidrag till invånarnas omförhandling av sin relation till platsen mot mer hållbara vardagsvanor och
