Phosphorylation is one of the main post-translational modifications (PTMs) regulating protein function, where kinases reversibly add phosphate groups to specific amino acid residues (phosphosites). Kinase activity is altered in breast cancer (BC), resulting in loss of regulation of several cellular processes. Phosphoproteomics emerges as a powerful approach for profiling samples at phosphosite lev

När datorn blir kemistens bästa verktyg Datorbaserade verktyg blir mer och mer vanliga i de flesta verksamheter - och kemisk syntes är inget undantag. Genom att förutspå hur kemiska reaktioner sker redan innan de testas i labbet är det möjligt att spara tid, resurser och minska miljöpåverkan. Tekniken har därmed förändrat hur kemisk syntes planeras och genomförs. I många vitt skilda branscher spThe synthesis of small organic molecules in the pharmaceutical industry necessitates efficiency and selectivity. For obtaining selectivity in C(sp2)-H functionalization, thianthrenation has emerged as a promising method for furnishing electrophilic substrates, with thianthrene acting as a linchpin that facilitates selective functionalization through subsequent displacement reactions. This thesis u

This paper presents the first comprehensive analysis of the systematic archival erasure surrounding the mass killing of Afro-Caribbean laborers at Anna’s Hope during the Fireburn uprising on St. Croix in 1878. Although internal telegrams and eyewitness accounts refer explicitly to a "great slaughter" of Black insurgents at Anna's Hope on 3 October 1878, the incident is conspicuously absent from of

Med bakgrund av egna erfarenheter har vi sett att nybörjarstadiet är kritiskt i improvisationsundervisningen samt att det ofta saknats konkreta verktyg för att lära sig att improvisera. Syftet med studien har därför varit att undersöka hur man introducerar improvisation för ovana improvisatörer, samt att identifiera vilka faktorer som underlättar elevens utveckling. Vårt fokus för studien har variFrom personal experience we have observed how critical the beginner stage of learning musical improvisation is to future studies in the subject, and how there seems to be lacking a consistent approach to introduce beginner students to improvisation. This study aims to examine how improvisation is introduced to beginner improvisers as well asidentify which factors facilitate a student’s progression

In the 1980s, the fantasy role-playing game Dungeons & Dragons underwent a controversy, as the game was accused of being satanic, occult, or otherwise dangerous. This essay seeks to create a deeper and more holistic understanding of how US. American Christian evangelicals imagined the game Dungeons & Dragons from 1979 to 1991. A variety of written source material is analysed using qualitat

A biographical ideology-analysis of Sven Arvid Flory’s diaries, 1932‒1941. This study follows the diaries of the Swedish officer Sven Arvid Flory from 1932 through 1941, analysing the political and personal notes made and relating them to broader frameworks of ideology. First impressions of the material hinted at nazi sympathies. The study then focused on these ideological aspects of the diaries,

This thesis examines the causes and effects of the 1762 prohibition introduced by the Swedish diet against the collection of seabird eggs. The study lies at the intersection of environmental, political, animal, and hunting history, focusing on environmental regulations concerning huntable species imposed by political authorities. Previous research has largely accepted the prohibition as a given, w

The dream of woman : the construction of hegemonic femininity and the woman’s place in bourgeois culture in the Swedish and British fashion press, 1830–1855. This thesis investigates the construction of hegemonic femininity in British and Swedish fashion periodicals between 1830 and 1855, a period often overlooked in history research. Through an intersectional lens, drawing on theories of fashion

In the following study a collection of almost 300 travelogues from the second half of the 19th century is investigated. The travellers were technicians in the sense that they were technically knowledgeable and skilled individuals. The technicians, most of them skilled workers, travelled through the industrialised countries in Europe as well as the United States. During their travels they worked in

To Not Submit: A Microhistorical Study of a Young Woman’s Diaries from Helsingborg 1941–1945. This study examines seven diaries containing approximately 120,000 words. They were written in 1941-1945 by a woman born in 1925 in a bourgeois household in the Scanian port town of Helsingborg. The diaries are contextualized through literary theory as a journal in-time. They are also interpreted within a

Parallel to the intensified digitization of financial transactions, an ancient informal system continues to operate in the shadows, exerting a significant influence on global financial structures. Hawala, as this system is known, is recognized for its dual nature, allowing it to function as a legitimate financial system, while its informal structure, particularly its lack of governmental oversight

The snitch is a well known figure, often associated with deceit and betrayal. It appears in everyday life, embedded in joking jargons as well as in serious discussions of loyalty. Perhaps most significantly, the snitch symbolizes the culture of silence within criminal gangs, breaking the unwritten rule of not speaking to authorities. This thesis investigates how the figure of the snitch, and the a

Authors: Ellinor Lantz & Linn Modée This thesis has been a complete collaboration between the two authors. Each author has been involved in every part of the process and contributed equally. Supervisors: Ebba Eriksson Ahre, Division of Engineering Logistics, Faculty of Engineering, Lund University Angela van der Sluijs, Head of Transport SMS Logistics, Sandvik Problem description: Scope 3 fr

This study examines how different forms of agency facilitate or hinder the reconceptualization of poverty during Sri Lanka's transition from the Samurdhi program to the Aswesuma Welfare Benefit Scheme and analyzes its impact on targeting efficiency. The research addresses a critical gap in comprehending how transformations from income-based to multidimensional poverty measurement frameworks ar

This thesis examines how Poland’s abortion law affects access to pregnancy termination, using feminist ethics, human rights framework, and the concept of secondary violence. Although abortion is legally allowed in limited situations, the study shows that in practice, access is often blocked by institutional barriers and doctors’ refusal to act. The research analyses documented cases in which abort

Syftet med denna studie är att undersöka kvinnors roll i hedersrelaterade kontexter. Studien fokuserar på hur kvinnor kan ses som både offer och förövare inom hedersrelaterat våld och förtryck. Studien är baserad på fem kvalitativa intervjuer med yrkesverksamma inom området. Studiens resultat analyseras med hjälp av teorin om internalisering, symboliskt våld samt Foucaults maktteori. Resultatet be

Den effektiva marknadshypotesen säger att det inte går att finna någon form av strategi som riskjusterat avkastar bättre än de finansiella marknaderna. Vidare har det påvisats att autokorrelationen för enskilda aktier historiskt varit låg vilket tyder på att exempelvis teknisk analys torde tillföra lite värde för någon som ämnar avkasta bättre riskjusterat än den breda marknaden. I denna uppsats tIn this thesis it was evaluated whether it is possible to risk-adjusted outperform the naive, buy and hold, approach for Swedish, listed investment companies. The key metric for this objective was, first and foremost, the Sharpe ratio and secondly the Sortino ratio. To do this, a random forest model was used along with a regime filter. The prediction horizon was one day meaning that at the end of

Rising logistics costs and inefficiencies caused by Lindab Group’s current internal markup structure have prompted the company to consider a new logistics model. This study examines the feasibility of developing an internal third-party logistics (3PL) provider as a way to improve operations, increase profit and enhance coordination across the group. The research maps current distribution flows, id

Background and Aims: Population-based data on prescribed opioid use among adults with Crohn's disease (CD) remain limited. Methods: This nationwide register-based study included individuals ≥ 18 years with incident (2008–2019) or prevalent (2008–2021) CD and up to 10 individually matched reference individuals without inflammatory bowel disease. We categorised opioid dispensations as weak (e.g., tr