Filetype
Background: α-synuclein (α-syn) aggregation can lead to degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) as invariably observed in patients with Parkinson's Disease (PD). The co-chaperone DNAJB6 has previously been found to be expressed at higher levels in PD patients than in control subjects and was also found in Lewy bodies. Our previous experiments showed that k
Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity
The tick-transmitted bacterium Borrelia afzelii consists of a number of antigenically different strains — often defined by outer surface protein C (OspC) genotype — that coexist at stable frequencies in host populations. To investigate how host antibody responses affect strain coexistence, we measured antibody cross-reactivity to three different OspC types (OspC 2, 3 and 9) in three different stra
The two-dimensional nature of mammography makes estimation of the overall breast density challenging, and estimation of the true patient-specific radiation dose impossible. Digital breast tomosynthesis (DBT), a pseudo-3D technique, is now commonly used in breast cancer screening and diagnostics. Still, the severely limited 3rd dimension information in DBT has not been used, until now, to estimate
The impact of longitudinal vibration on cross-bridge attachments between myofilaments was investigated in single fibres and intact muscle. Sinusoidal length vibration (frequency 50 Hz, amplitude 5% of fibre length) reduced active force by 40% when fibres were activated by elevation of [Ca2+], but did not alter the force when fibres were in rigor state. When vibrated for 30 min in rigor at pH 5.5 a
Thirty-nine years of high-resolution data from 1981 to 2019 surveyed by the Field Research Facility (FRF) of the US Army Corps of Engineers at Duck, North Carolina, in the United States, were analyzed for temporal and spatial characteristics of beach morphology evolution employing a range of statistical methods. In the study, emphasis was put on the response of the subaerial part of the beach prof
The Nile tilapia, Oreochromis niloticus, is an important species for global aquaculture. Recently, a single genetic line of Nile tilapia was developed using estimated breeding values (EBVs) for body weight under moderately saline water that showed significant improvement in growth performance. To explore the molecular mechanisms underlying this enhanced growth capacity, RNA-Seq was used to profile
Sediments are a key sink for phosphorus (P) in coastal systems. This allows coastal areas to act as a filter for P that is transported from land to sea. Recent work suggests that vivianite-type ferrous iron (Fe(II))-P minerals may be more important as a sink for P in coastal sediments than previously thought. Here, we investigate the occurrence of such vivianite-type minerals in sediments of three
Galactomannan (GM) in legumes and acetyl-galactoglucomannan (AcGGM) in softwoods are wide-spread β-mannans. Their depolymerisation is catalyzed by β-mannanases. We have investigated a cell-surface exposed and galactose-tolerant β-mannanase (BoMan26B) from the abundant gut bacterium Bacteroides ovatus. Glycosidases from the gut microbiota have potential for production of prebiotics, such as dietary
Background: Regenerex® is a porous titanium construct with a 3D interconnecting pore structure and biomechanical characteristics close to that of normal trabecular bone. This study aimed to compare the Regenerex (VR) to the non-interconnecting pore structure Porous Plasma Spray (VP) on tibial implants for total knee arthroplasty (TKA) at 5 years. Methods: We enrolled and randomized 61 patients (me
Background: Few data have looked at the occurrence and clinical correlates of self-reported shorter than desired ejaculation latency (rapid ejaculation, RE) and its related distress in the general population. Aim: To determine the prevalence and clinical correlates of self-reported RE and RE- related distress in middle age and older European men. Methods: Subjects were recruited from population sa
The comprehensive prehistoric settlement Uppåkra, lasting over a millennium,raises questions on how food supplies and local communities were agriculturally organized. Recent investigations of archaeobotanical remains from theregional center Uppåkra and several surrounding settlements have contributed to new aspects of their agricultural relations. New patterns in consumption show that through i
Background: Burns are a global public health concern, with the majority of the disease burden affecting low- and middle-income countries. Yet, as suggested by previous publications, there is a widespread belief that literature about burns in low- and middle-income countries is lacking. Therefore, we aimed to assess with a scoping review, the extent of the literature output on burns in East Africa,
“Wet” eldercare facilities for people who age with long-term substance use problems and complex needs exist in several countries. Residents are accepted as active users of alcohol and drugs, and while the media has presented the permissive policies of the facilities in a positive light, others have described these policies as harmful. The aim of this article is to analyze residents' and staff memb
The roughly 600 km long Central Cordillera of Colombia shows a varied tectonic, magmatic, and exhumation history, despite the reasonably homogenous appearance concerning topography, outcropping lithologies, and strike. Here we show with new geo-thermochronological data the thermal evolution of the southern Central Cordillera since the Early Jurassic. Extensive Jurassic magmatism is recorded by U–P
The general outline of the long-term history of cereal cultivation in southern Sweden is relatively well known from published compilations of archaeobotanical data (Hjelmqvist 1955; Engelmark 1992; Gustafsson 1998; Viklund 1998; Grabowski 2011). These compilations show emmer (Triticum dicoccum) and naked barley (Hordeum vulgare var. nudum) as the principal crops of the Neolithic and the Early Bron
Drug use disorders (DUD) are associated with psychiatric illness and increased risks of suicide. We examined health care utilization prior to suicide in adults with DUD, which may reveal opportunities to prevent suicide in this high-risk population. A national cohort study was conducted of all 6,947,191 adults in Sweden, including 166,682 (2.4%) with DUD, who were followed up for suicide during 20
Functional data analysis is typically performed in two steps: first, functionally representing discrete observations, and then applying functional methods, such as the functional principal component analysis, to the so-represented data. While the initial choice of a functional representation may have a significant impact on the second phase of the analysis, this issue has not gained much attention
Magnetic fields can alter the growth of nanomaterials and, in some cases, ultimately lead to room temperature ferromagnetism (RTF). One promising approach for the growth of nanomaterials is thermal oxidation with both academic and industrial relevance. In this study, we evaluate the growth of copper oxide (CuO) nanowires by thermal oxidation method in a furnace adapted with a static magnetic field
Although virus-negative Merkel cell carcinoma (MCC) is characterized by a high frequency of UV-induced mutations, the expression of two viral oncoproteins is regarded as a key mechanism driving Merkel cell polyomavirus‒positive MCC. The cells in which these molecular events initiate MCC oncogenesis have yet not been identified for both MCC subsets. A considerable proportion of virus-negative MCC i
