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Neuroblastoma exhibits two cellular phenotypes: therapy-sensitive adrenergic (ADRN) and therapy-resistant mesenchymal (MES). To understand treatment response, it is important to elucidate how these phenotypes impact the dynamics of cancer cell populations and whether they represent distinct cell types or dynamic cell states. Here, we use an integrated experimental and mathematical modeling approac

Background: High breast density is an independent risk factor for breast cancer and decreases the sensitivity of mammography. This systematic review synthesizes the international clinical guidelines and the evidence base for screening and supplemental screening recommendations in women with dense breasts. Methods: A systematic search of CINHAL, Embase, and Medline databases was performed in August

Understanding wildlife stakeholders is vital in mitigating the risk for inertia in the implementation of management and illegal activities, e.g., poaching. We used a unique set of questionnaire data of stakeholders in Sweden (n = 8728) comprising birdwatchers, hunters, farmers, and the general public, to analyze evaluations of geese, beliefs about goose management at multiple levels, and acceptanc

This chapter reflects on the need for a decolonial turn in Sweden’s foreign policy. The growing ecological emergencies that we are faced with call on us to recognise and address quite profound global inequities, many of which are rooted in histories of European colonialism. In a sprawling conversation about the coloniality of the global economy and Sweden’s role in it, the chapter addresses such t

A people-centred approach for designing large-scale built-up spaces necessitates systematic anticipation of user’s embodied visuo-locomotive experience from the viewpoint of human-environment interaction factors pertaining to aspects such as navigation, wayfinding, usability. In this context, we develop a behaviour-based visuo-locomotive complexity model that functions as a key correlate of cognit

Climate modeling suggests that achieving international climate goals requires a reduction in current CO2 emissions by over 90%, with any remaining emissions to be addressed through carbon dioxide removal (CDR) solutions. Sixteen CDR strategies are evaluated by integrating technical potential, environmental, social, and governance (ESG) criteria, along with sequestration permanence. This evaluation

Patients with aortic root abscesses experience increased morbidity and mortality compared to those without abscess in aortic valve infective endocarditis. The superior intervention for patients with aortic root abscess is not determined. This research investigates the degree to which increased morbidity and mortality of aortic root abscess, and to describe perioperative characteristics and outcome

Background: The spread of tau pathology closely correlates with the disease course and cognitive decline in Alzheimer’s disease (AD). Tau-targeting immunotherapies are being developed to stop the spread of tau pathology and thus halt disease progression. In this post hoc analysis of the ADAMANT clinical trial, we examined the performance of AADvac1, an active immunotherapy targeting the microtubul

Lipid storage myopathies are considered inborn errors of metabolism affecting the fatty acid metabolism and leading to accumulation of lipid droplets in the cytoplasm of muscle fibers. Specific diagnosis is based on investigation of organic aids in urine, acylcarnitines in blood and genetic testing. An acquired lipid storage myopathy in patients treated with the antidepressant drug sertraline, a s

Body dysmorphic disorder (BDD) is a relatively common and highly impairing mental disorder that is strikingly underdiagnosed and undertreated in Child and Adolescent Mental Health Services (CAMHS). The only clinical guidelines for the management of BDD in youth were published nearly 20 years ago, when empirical knowledge was sparse. Fortunately, there has been a surge in research into BDD over the

The Covid-19 pandemic significantly influenced public discourse, particularly on the use of face masks, with social media serving as a platform for the public to express their opinions and share experiences. This study examines how the Swedish public supports their arguments when discussing their stance on face masks during the Covid-19 pandemic, split into three categories: (1) personal opinions,

The invasive golden apple snail Pomacea canaliculata is one of the devastating threats to aquatic ecosystems and wetland agriculture worldwide. Macrolides from microbes display various advantages over other compounds in controlling snails. However, emergence of antibiotic-resistant phenotypes against certain macrolides in the field appeals for exploring more effectively molluscicidal macrolides. H

A study of submicron-sized InGaN containing a single quantum well, intended for use as nano-light-emitting diodes in high-resolution display based on direct emission, is presented. Herein, the structures are grown by a bottom-up method from holes in a masked GaN/sapphire substrate and are intended for red emission. Many of the platelets show dark lines in cathodoluminescence images, previously ide

Welfare technology (WT), defined as digital technology enabling individuals to live securely, actively and independently at home, is often viewed as a solution to care resource shortages. This solution discourse has increasingly been problematised, and ethical issues specifically connected to WT have emerged, e.g., regarding quality of care. The existing array of WT is developed with limited user

School-based bullying is a widespread issue, but it occurs less often when bystanders defend the victims. This study examined whether type of bullying and students’ trust in their teacher’s ability to manage the class would be associated with reaction of the bystander (i.e. defending, passive, and pro-bullying). The participants were 202 ninth-grade students in Sweden, aged 15 years, who completed

Human–robot collaboration (HRC) in manufacturing environments requires that physical safety can be guaranteed. Control methods that implicitly regulate the interaction forces between a controlled robot and its environment, such as impedance control, are often used for safety in HRC. However, these methods could be complemented by restricting the robot operational space for additional safety guaran

Immunocompromised patients, especially those receiving B-cell depleting therapies, are at risk for developing atypical presentation with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, with the potential for diagnostic delay and adverse outcomes if such delay occurs. A 66-year-old female with history of granulomatosis with polyangiitis (GPA) with previous pulmonar

In this paper, an iterative learning strategy was developed to improve trajectory tracking for an impedance-controlled robot manipulator. In this learning strategy, an update law was proposed to modify the Cartesian reference of an impedance controller. Also, the conditions that ensure its convergence considering the dynamics of the robot were derived. Finally, an experimental evaluation was perfo