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Urinary tract infections activate a mucosal inflammatory response, which includes cytokine secretion and neutrophil influx. The mechanisms involved in the neutrophil influx have not been identified. Interleukin-8, a potent chemoattractant for neutrophils, is produced by urinary tract epithelial cell lines in vitro. This study analyzed the human IL-8 response to deliberate Escherichia coli infectio
Trauma and infection activated a murine mucosal IL‐6 response in different ways: the IL‐6 response to bacteria was sensitive to Cyclosporin A (CsA); the IL‐6 response to trauma was not. The aim of the present study was to identify possible activators of the CsA‐insensitive IL‐6 secretion at the epithelial cell level. Two human epithelial cell lines from the kidney (A498) and bladder (J82) were exp
DNA methylation patterns change with age and can be used to derive an estimate of "epigenetic age," an indicator of biological age. Several studies have shown associations of posttraumatic stress disorder (PTSD) with worse somatic health and early mortality, raising the possibility of accelerated biological aging. This study examined associations between estimated epigenetic age and various variab
Higher order calculations are necessary to predict and describe measurements in high energy collider physics. In recent years multiple approaches to combine multiple next-to-leading (NLO) order corrections with parton showers had been presented. We present on recent developments and future perspective. We highlight similarities and ambiguities in the procedure of achieving a multijet merging at NL
In this talk I presented an algorithm to correct for wrong assignment of colour dipoles in the cascade of dipole showers. It is explained how simple matrix elements can be used to reorder the colour connections for the evolution of the following cascade. I discuss the possibility to modify the splitting kernels to include an improved behaviour. Further a numerical study is presented that indicates
We present an algorithm to combine multiple matrix elements at LO and NLO with a parton shower. We build on the unitarized merging paradigm. The inclusion of higher orders and multiplicities reduce the scale uncertainties for observables sensitive to hard emissions, while preserving the features of inclusive quantities. The combination allows further soft and collinear emissions to be predicted by
We perform a detailed study of the sources of perturbative uncertainty in parton-shower predictions within the Herwig 7 event generator. We benchmark two rather different parton-shower algorithms, based on angular-ordered and dipole-type evolution, against each other. We deliberately choose leading order plus parton shower as the benchmark setting to identify a controllable set of uncertainties. T
This volume contains a selection of chapters concerning free will and moral responsibility. The problems arising in this field of philosophy, which are deeply rooted in the history of the subject, are also intimately related to a wide range of other fields, such as law and criminology, moral psychology, theology, and, more recently, neuroscience. The chapters included in this collection were writt
