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Pituitary cyclase-activating polypeptide targeted treatments for the treatment of primary headache disorders

Objective: Migraine is a complex and disabling neurological disorder. Recent years have witnessed the development and emergence of novel treatments for the condition, namely those targeting calcitonin gene-related peptide (CGRP). However, there remains a substantial need for further treatments for those unresponsive to current therapies. Targeting pituitary adenylate cyclase-activating polypeptide

Temporal dynamics of coarticulatory cues to prediction

The temporal dynamics of the perception of within-word coarticulatory cues remain a subject of ongoing debate in speech perception research. This behavioral gating study sheds light on the unfolding predictive use of anticipatory coarticulation in onset fricatives. Word onset fricatives (/f/ and /s/) were split into four gates (15, 35, 75 and 135 milliseconds). Listeners made a forced choice about

Navigating the gap between policy and practice : frontline and second-tier management perspectives and strategies in offering vocational and educational support to young adults with mental health problems

Mental health problems among young adults often lead to obstacles to completing higher education and becoming established in the labour market. It is important to offer support that can help these individuals realize educational and vocational goals in order to become self-sufficient and achieve social inclusion. Individual Placement and Support (IPS) and Supported Education (SEd) are two methods

Search for flavour-changing neutral-current couplings between the top quark and the Higgs boson in multi-lepton final states in 13 TeV pp collisions with the ATLAS detector

A search is presented for flavour-changing neutral-current interactions involving the top quark, the Higgs boson and an up-type quark (q=u,c) with the ATLAS detector at the Large Hadron Collider. The analysis considers leptonic decays of the top quark along with Higgs boson decays into two W bosons, two Z bosons or a τ+τ- pair. It focuses on final states containing either two leptons (electrons or