New generation sequencing (NGS) genetic testing is a powerful diagnostic tool and is increasingly used in the clinical workup of patients, especially in unusual presentations or where a positive family history suggests heritable disease. This review addresses the NGS technologies Targeted sequencing (TS), Whole exome sequencing (WES), Whole genome sequencing (WGS), and the use of gene panels or ge

The present prospective cohort study evaluates the effect of three-dimensional (3-D) endoscopy on outcome in transphenoidal endoscopic surgery of pituitary adenomas compared to conventional two-dimensional (2-D) endoscopy. Prospective data was collected from patients undergoing endoscopic surgery for pituitary adenomas before and after the introduction of 3-D endoscopy. Patients, grouped by having

Epi is a humanoid robot developed by Lund University Cognitive Science Robotics Group. It was designed to be used in experiments in developmental robotics and has proportions to give a childlike impression while still being decidedly robotic. The robot head has two degrees of freedom in the neck and each eye can independently move laterally. There is a camera in each eye to make stereovision possi

The electron kinetics in nanowire-based hot-carrier solar cells is studied, where both relaxation and extraction are considered concurrently. Our kinetics is formulated in the many-particle basis of the interacting system. Detailed comparison with simplified calculations based on product states shows that this includes the Coulomb interaction both in lowest and higher orders. While relaxation rate

Based on observations in vivo in guinea-pig and human airways, this review presents plasma exudation as non-sieved transmission of bulk plasma across an unperturbed mucosa that maintains its normal barrier functions. Several steps have led to the present understanding of plasma exudation as a non-injurious response to mucosal challenges. The implication of a swift appearance of all circulating mul

En lundensisk stadsläkare, en dansk diktare, och en pappersfabrikants dotter bor under samma tak – det skulle kunna vara inledningen på ett dålig vits, men är i själva verket början på ett kärleks- och triangeldrama som skakade Lund under andra halvan av artonhundratalet. Arkivarien vid universitetsarkivet Henrik Ullstad skriver om en äktenskapsskandal som slog sönder familjer, krossade en lovandeA town medical officer in Lund, a Danish poet and a paper manufacturer’s daughter living under the same roof – it could be the start to a bad joke, however, it is actually the start of a dramatic love triangle that shook Lund during the second half of the nineteenth century. University archivist Henrik Ullstad writes about a relationship scandal that destroyed families, crushed a promising career,

Immunotherapeutic modalities are currently revolutionizing cancer treatment. In pancreatic cancer, however, early clinical trials have been disappointing. The optimization of immunotherapeutic strategies requires better understanding of the inflammatory tumor microenvironment. Therefore, the aim of our study was to perform a detailed in situ description of lymphocyte infiltration patterns in resec

The 2014 Êzîdî Genocide caused a rupture in the social fabric of the Iraqi religious Êzîdî minority. A search for meaning in the aftermath of violence has caused a group of Şingalî poets to reconstruct memories of the past through their narration in Arabic prose poetry. A narrative analysis has been used on a selection of poems written and interviews conducted with five poets. I investigate their

Your body is not a point particle. The nature and direction of the forces counteracting gravity influence your experience of uniform rectilinear motion- A s does your own orientation in relation to the force of gravity. Sensors in smartphones or other devices can capture these forces, and help establish a connection between the personal experience of motion and the textbook description of forces a

During winter at temperate and high latitudes, the low ambient temperatures, limited food supplies and short foraging periods mean small passerines show behavioural, morphological and physiological adaptations to reduce the risk of facing energy shortages. Peripheral tissues vasoconstrict in low ambient temperatures to reduce heat loss and cold injury. Peripheral vasoconstriction has been observed

Background and Purpose: Inhibition of the G-protein gated ACh-activated inward rectifier potassium current, IK,ACh may be an effective atrial selective treatment strategy for atrial fibrillation (AF). Therefore, the anti-arrhythmic and electrophysiological properties of a novel putatively potent and highly specific IK,ACh inhibitor, XAF-1407 (3-methyl-1-[5-phenyl-4-[4-(2-pyrrolidin-1-ylethoxymethy

Background: Maternal anti–human leukocyte antigen (HLA) Class I is commonly detected alongside anti–human platelet antigen (HPA)-1a in fetal and neonatal alloimmune thrombocytopenia (FNAIT). Little is known regarding whether the presence of anti-HLA Class I may exert an additive effect on the risk and severity of FNAIT. Methods and Materials: We reanalyzed samples originally collected as part of a

Radiation therapy is part of the standard of care for gliomas and kills a subset of tumor cells, while also altering the tumor microenvironment. Tumor cells with stem-like properties preferentially survive radiation and give rise to glioma recurrence. Various techniques for enriching and quantifying cells with stem-like properties have been used, including the fluorescence activated cell sorting (

To shed light on the interaction between macroprudential and monetary policies, we study the inward transmission of foreign monetary policy in conjunction with domestic macroprudential and monetary policies in Norway and Sweden. Using detailed bank-level data we show how Norwegian and Swedish banks’ lending reacts to monetary policy surprises arising abroad, controlling for the domestic macroprude

The coronavirus disease 2019 (COVID-19) pandemic led to an abrupt halt of many Alzheimer's disease (AD) research studies at sites spanning the world. This is especially true for studies requiring in-person contact, such as studies collecting biofluids. Since COVID-19 is likely to remain a threat for an extended period, the resumption of fluid biomarker studies requires the development and implemen