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Malignant brain tumor is a highly invasive and vascularized cancer. Current forms of therapy are not curative and can, at best, prolong survival for patients with this disease. The mean survival is only around 15 months. The aims of the present thesis have been to develop and explore a stem cell based vector system for delivery of therapeutic transgenes to experimental gliomas. First, we investiga
Newborn male infants have higher morbidity and mortality than female infants. Male fetal gender is associated with an overall increased risk of preterm birth and complications related to pregnancy are overrepresented in women carrying male fetuses. Several studies have shown that being newborn and of male gender are independent risk factors for adverse outcome. Even though experimental data from n
A novel algorithm for detection of saccades and postsaccadic oscillations in the presence of smooth pursuit movements is proposed. The method combines saccade detection in the acceleration domain with specialized on- and offset criteria for saccades and postsaccadic oscillations. The performance of the algorithm is evaluated by comparing the detection results to those of an existing velocity-based
Popular Abstract in Swedish Diabetes mellitus är en folksjukdom som blir allt vanligare, sannolikt till stor del på grund av vår moderna livsstil. Individer med diabetes löper större risk att utveckla många olika komplikationer, bland annat i ögonen, njurarna, blodkärlen och magtarmkanalen. Många diabetiker drabbas av förlångsammad tömning av magsäcken, vilket även kallas gastropares. Gastropares Gastrointestinal dysmotility is common, particularly in patients with diabetes mellitus. The aim of this thesis is to explore whether gastrointestinal dysmotility and endocrine secretion are interrelated, and how the symptoms manifest themselves in these patients. Patients with diabetes mellitus and gastrointestinal symptoms underwent gastric emptying scintigraphy, esophageal manometry and deep-
This article studies partner selection according to three dimensions: social origin, age, and place of birth. The authors use micro-level data from local population registers in five parishes in southern Sweden from 1815 to 1895.The results confirm that all three aspects were important but that socioeconomic status was the most important characteristic,structuring much of the selection process.The
Interest in cross-national partnership is increasing in Europe, a situation very much reflected in calls for funding. Multi-language qualitative research methodologies need to be strengthened in order to support this growing trend toward the promotion of cross-national collaboration. This practice analysis reports on our experience of carrying out cross-national and multi-language based qualitativ
We assessed potential toxicity of fungicides to natural bacterial communities from a constructed wetland, located in southern Sweden, and compared the sensitivity of two endpoints indicating bacterial activity, leucine incorporation, and potential denitrification, in detecting toxicity. The effects of eight fungicides (benomyl, carbendazim, carboxin, captan, cycloheximide, fenpropimorph, propicona
Auger spectra from the decay of core-ionized N-2 have been studied as a function of the exciting photon energy. Discrete features appear in the Auger spectrum when the photon energy is tuned to the shape-resonance region at 420 eV. The Auger spectra for two final dicationic states are studied; simulations of the contributions from the decay of the gerade and ungerade core-hole states are made base
The fragmentation of relativistic uranium projectiles has been exploited at the Gesellschaft für Schwerionenforschung laboratory to investigate the β decay of neutron-rich nuclei just beyond 208Pb. This paper reports on β-delayed γ decays of 211–213Tl, 215Pb, and 215–219Bi de-exciting states in the daughters 211–213Pb, 215Bi, and 215–219Po. The resulting partial level schemes, proposed with the he
The aim of this study was to conduct radiographic and histomorphometric analysis of bone healing in the calvaria of rabbits, using an autogenous graft associated with PRP obtained by 2 different methods. Thirty rabbits were divided into control and experimental groups. Lesions were produced in the calvaria and filled with autogenous graft ( control) or autogenous graft and PRP obtained by the Anit
Aim To describe gender difference in a total population of children with cerebral palsy (CP), related to subtype, gross and fine motor function, and to compare CP incidence trends in girls and boys. Methods All 590 children with CP born in southern Sweden 1990-2005 were included. CP subtype was classified according to the Surveillance of Cerebral Palsy in Europe, gross motor function according to
In this paper, we address the dynamic spectrum allocation problem in next generation cellular networks under the coordinated dynamic spectrum access (CDSA) model. Firstly, considering spectrum demands of base stations, we formulate spectrum allocation under physical interference models as a nonlinear optimization problem. Then, we propose a demand-driven dynamic spectrum allocation algorithm by tr
Women with endometriosis often experience gastrointestinal symptoms. Gonadotropin-releasing hormone (GnRH) analogs are used to treat endometriosis; however, some patients develop gastrointestinal dysmotility following this treatment. The aims of the present study were to investigate gastrointestinal symptoms among patients with endometriosis and to examine whether symptoms were associated with men
A large number of photovoltaic systems have been installed in developing countries around the world during numerous projects. The goal is often to improve the quality of life in rural areas often lacking electricity. Many of these installations provide important services such as lighting and charging of various devices. However, when the projects are finished, there is a large risk that maintenanc
The mechanoreceptive lateral line system in fishes detects hydrodynamic stimuli and plays a critical role in many fundamental behaviours, including orientation to water currents and the detection of stationary objects, prey and predators. Interspecific variation in lateral line structure may result from a process of functional adaptation, with the background level of hydrodynamic activity proposed
We present an investigation of the magnetic behavior of epitaxial MnAs films grown on GaAs(100). We address the dependence of the magnetic moment, ferromagnetic transition temperature (T-c), and magnetocrystalline anisotropy constants on epitaxial conditions. From thorough structural and magnetic investigations, our findings indicate a more complex relationship between strain and magnetic properti
Diabetes is a common metabolic disorder in patients with Friedreich ataxia. In this Supplement article, we review the clinical data on diabetes in Friedreich ataxia, and the experimental data from rodent and in vitro models of the disease. Increased body adiposity and insulin resistance are frequently present in Friedreich ataxia, but pancreatic cell dysfunction and death are a conditio sine qua n
