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Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV600E) from the thyroglobulin promoter (TgCreERT2). Spontaneous activation of this Braf-mutant allele
Background: To engage people who inject drugs (PWID) in HCV care, innovative models of care are urgently needed. A needle exchange program (NEP) could serve as an ideal platform for comprehensive HCV management including post treatment follow up. Methods: 50 actively injecting patients at the Malmö Needle exchange program (MNEP) were consecutively enrolled between April 2018 and May 2019. All pati
Soil moisture can strongly affect the fate of soil organic carbon (C) during microbial decomposition, but the characterisation and prediction of the effects remain challenging, especially the long-term effects of drought history and its interaction with current levels of soil moisture. We investigated the legacy effects of drought on soil activity and microbial community composition and its intera
Elevated arsenic (As) in soil is of public concern due to the carcinogenicity. Phosphorus (P) strongly influences the adsorption, absorption, transport, and transformation of As in the soil and in organisms due to the similarity of the chemical properties of P and As. In soil, P, particularly inorganic P, can release soil-retained As (mostly arsenate) by competing for adsorption sites. In plant an
This article analyses how Sweden has adapted to the worsened security situation in its vicinity following Russia’s illegal annexation of Crimea and war in Eastern Ukraine. The paper builds on security policy research focused on neoclassic realism and small state strategies in order to explore how the, broadly unknown, security policy from 2009 has been implemented in practice since 2014, through w
Spermine oxidase (SMOX) catalyzes the oxidation of spermine to spermidine. Observational studies have reported SMOX as a source of reactive oxygen species associated with cancer, implying that inhibition of SMOX could be a target for chemoprevention. Here we test causality of SMOX levels with cancer risk using a Mendelian randomization analysis. We performed a GWAS of spermidine/spermine ratio to
Alternative reproductive tactics (ARTs) often exhibit more than one mating behavior depending on social context (i.e., behavioral plasticity). It has been hypothesized that by constraining an ART from reaching optimal morphological states, intralocus tactical conflict could promote the maintenance of behavioral plasticity in ARTs, rather than the use of a fixed mating behavior to match an optimal
Purpose: At the inception of the Journal of Humanitarian Logistics and Supply Chain Management (JHLSCM), logistics coordination was identified as important, both in practice and research, but few studies on the topic had been published. Ten years later, many, if not most, papers in the journal mention the topic. So the picture has changed, but to what extent? This paper discusses how coordination
Purpose: To report the incidence of postoperative endophthalmitis (PE) after immediate sequential bilateral cataract surgery (ISBCS) in Sweden. Design: Retrospective cohort registry study. Participants: Patient data from 1 457 172 cataract extractions, including 1 364 934 unilateral surgeries and 92 238 ISBCSs. Methods: Endophthalmitis cases reported to the Swedish National Cataract Register (NCR)
