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WNT/β-catenin signaling is a highly complex pathway that plays diverse roles in various cellular processes. While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent manner rests upon the type of co-receptors used. Canonical WNT signaling is β-catenin-dependent, whereas non-canonical WNT signaling is β-catenin-indep
We reported that high estrogen receptor beta (ERβ) expression is independently associated with better prognosis in female colorectal cancer (CRC) patients. However, estrogen receptor alpha (ERα) is expressed at very low levels in normal colon mucosa, and its prognostic role in CRC has not been explored. Herein, we investigated the combined role of ERα and ERβ expression in the prognosis of female
While quantum fluctuations in binary mixtures of bosonic atoms with short-range interactions can lead to the formation of a self-bound droplet, for equal intracomponent interactions but an unequal number of atoms in the two components, there is an excess part that cannot bind to the droplet. Imposing confinement, as here through periodic boundary conditions in a one-dimensional setting, the drople
Salt aerosols play important roles in many processes related to atmospheric chemistry and the climate systems on both Earth and Mars. Complicated and still poorly understood processes occur on the salt surfaces when interacting with water vapor. In this study, ambient pressure X-ray photoelectron spectroscopy (APXPS) is used to characterize the surface chemical environment of Martian salt analogue
Background. Pervasive refusal syndrome (PRS) is a severe child psychiatric syndrome not yet included in the international classification and mostly affecting girls aged 7-15 years. Hospital admission and severe loss of function extend for many months and years but most recover. Autism has been suggested as a predisposing factor but largely lacks support for typical cases of PRS. Treatment is not e
Background Tuberculosis is among the leading causes of death among infectious diseases. Regions with a high incidence of tuberculosis, such as sub-Saharan Africa, are disproportionately burdened by stillbirth and other pregnancy complications. Active tuberculosis increases the risk of pregnancy complications, but the association between latent tuberculosis infection (LTBI) and pregnancy outcomes i
Currently, static cold storage (SCS) of hearts from donations after brainstem death remains the standard clinically. However, machine perfusion (MP) is considered an approach for donor organ management to extend the donor pool and/or increase the utilization rate. This review summarizes and critically assesses the available clinical data on MP in heart transplantation. We searched Medline (PubMed)
In international law, new norms can emerge through the identification and development of effective practices. This article examines Swedish, Finnish and, less closely, other Nordic countries’ contributions to the slow process of norm emergence in relation to cross-border displacement in the context of disasters and climate change. It focuses on Sweden and Finland’s early adoption, and subsequent j
We provide an abstract approach to approximation with a wide range of regularity classes X in spaces of pseudocontinuable functions Kp Θ, where Θ is an inner function and p > 0. More precisely, we demonstrate a general principle, attributed to A. Aleksandrov, which asserts that if a certain linear manifold X is dense in Kq Θ for some q > 0, then X is in fact dense in Kp Θ for all p > 0. Moreover,
Introduction Covid-19 can cause chronic hypoxic respiratory failure, but the impact on the need for long-term oxygen therapy (LTOT) is unknown. The aim was to investigate change in incidence and characteristics of patients starting LTOT in Sweden 2020 after the outbreak of the pandemic. Material and methods Population-based observational study using data from the National Registry for Respiratory
Deficiencies in software or computer chips cause computers or smartphones to crash and allow hackers to steal passwords. Automated test procedures could avoid these problems. However, the computing power and cooling requirements of conventional computers increase exponentially with the size of the problem, so that the technological limits for solving these problems will soon be reached. The EU pro
Purpose: To evaluate if preoperative assessment with A Quick Test of Cognitive Speed (AQT) could increase the accuracy of predicting delirium after cardiac surgery compared to Mini-Mental State Examination (MMSE), and examine if a composite of variables, including cognitive function and depressive symptoms, could be useful to predict delirium. Patients and Methods: Cardiac surgery was performed in
Using methods from complex analysis we obtain some qualitative results for the kinetic energy of two-dimensional irrotational water flows (monotonicity of horizontal averages with depth, location of the extrema).
In this work, supercritical n-decane flowing in ducts with different orientations is thoroughly investigated in terms of secondary flow, wall shear stress, and thermal acceleration. It is known that the secondary flow strength hardly plays a role in cases of flowing upward, flowing downward, or flowing horizontally at a small heat flux/mass flux. Still, an attachment point can be found at the cent
