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BACKGROUND: Reliable biomarkers for amyotrophic lateral sclerosis (ALS) are urgently needed due to diagnostic and prognostic challenges. This systematic review and meta-analysis aimed to synthesize recent evidence on the utility of blood and cerebrospinal fluid (CSF) biomarkers for ALS.METHODS: We systematically reviewed studies published from January 1, 2019 to March 25, 2025, that evaluated bloo

There has been a growing interest in how workers in high-carbon industries are impacted by low-carbon transitions and how such transitions can be implemented in a way that is just. This study explores the socio-cultural dimensions of these processes, focusing on the role of identity in shaping workers’ perceptions of low-carbon transitions and their ability to navigate change. It does so through a

The international humanitarian system has, since the 19th century, been activated during large-scale disasters when the capacities of the affected countries are overwhelmed. It comprises international humanitarian organizations (IHOs) and is funded by a variety of donors. Recently, this system has faced increasing criticism, mainly because of its failure to empower and include local and national a

Birds migrate across the globe on their wings, a behavioural adaptation that allows birds to exploit seasonal environments. Their migrations are ultimately influenced by their ability to fly, a costly but high energy-efficient mode of locomotion that enables birds to travel far distances in a short amount of time. This thesis investigates bird migration from a flight energetic perspective, focusin

Conventional diagnostic methods often involve long incubation times due to limited fluid mixing in confined spaces, despite offering high sensitivity. Therefore, acoustic streaming was employed to enhance microscale advection, thereby improving biomolecular interactions and reducing assay duration. The micromixing capability was demonstrated by dispersing methylene blue (MB) in deionized water and

Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit

Background: The COVID-19 pandemic accelerated the use of telemedicine, specifically video consultations as they provide healthcare access in challenging situations where face-to-face encounters are not possible. Nevertheless, it remains largely unknown to what extent the organisation of general practice and national digital infrastructures have impacted the uptake and use of video consultations. O

Pathogenic bacterial infections lead to bacterial resistance and biofilm formation, causing significant suffering and presenting an urgent issue to be addressed. Polymer materials have garnered considerable attention in the antibacterial field due to their functional moldability and molecular structure designability. These materials can achieve various antibacterial functions by regulating their m

Background: The ability of modern ultrasound machines to detect signs of enthesitis has increased, yet there is a lack of studies on patients with long-standing radiographic axial spondyloarthritis (r-axSpA). Hence, we aimed to investigate the prevalence and clinical significance of Doppler signals indicative of inflammation in peripheral entheses of patients with long-standing disease. Methods: P

Objective: Primary care is the base in many health care systems, and to identify the most registered diagnoses in primary care is a way to identify the overall health care use and needs in society. We estimated the rates of the 30 most common diagnoses in primary health care and their male to female ratio. Research design and methods: This was a study including inhabitants 18 years and older out o

Mutations causing Parkinson’s disease (PD) give diverse pathological phenotypes whose cellular correlates remain to be determined. Those with PRKN mutations have significantly earlier selective vulnerability of dopamine neurons, those with SNCA mutations have increased alpha-synuclein deposition, while those with LRRK2 mutations have additional deposition of tau. Yet all three mutation types are i

Water resource recovery facilities face challenges with increasingly stringent effluent demands, complexity and demand for capacity increasing investments. Emerging technologies such as digital twins could alleviate these problems but require high frequency influent data. This work presents a method for utilising measurements in the primary clarifier effluent with a model of the processes between

Concertos for bass tuba from the mid-nineteenth century, recorded between January - July 2025 using a copy of a Moritz-Wieprecht bass tuba, the original tuba patented in Berlin in 1835.

Sweden’s art and music schools (SAMS), established in the 1940s, provideaffordable extra-curricular instrumental and singing teaching for everychild, regardless of their family’s financial situation. Tuition is heavilysubsidised, with families contributing only some 7% of the cost. WhileSAMS traditionally offer one-to-one instruction, a recent governmentalreport (2016) advocates for group teaching

Recent years has seen increasing interest in the concept of affordances in music performance research. Hereby, the agency of musical instruments is understood as defined by the perceived opportunities for action emerging through the sensorimotor relationship (i.e. the continuous interaction between musician and instrument). As such, it is an analytical perspective that highlights material and embo

Denna uppsats analyserar de rättsliga kriterier som avgör huruvida ett företag anses ha ett fast etableringsställe (FE) i mervärdesskatterättslig mening enligt EU-rätten, med särskilt fokus på bestämmelserna om beskattningsland vid tillhandahållande av tjänster. Begreppet FE är inte fullt ut definierat i mervärdesskattedirektivet, men har preciserats genom artikel 11 i tillämpningsförordningen ochThis thesis analyses the legal criteria that determine whether a company has a fixed establishment for VAT purposes under EU law, with particular focus on the place of supply of services. The concept of a FE is not fully defined in the VAT Directive but is clarified through Article 11 of the Implementing Regulation and further developed in the case law of the Court of Justice of the European Union

Betong används över hela världen men tillverkningen ger stora koldioxidutsläpp. I detta arbete undersöktes hur tillsats av slagg, en biprodukt från metallproduktion, påverkade betongens tidiga hållfasthet och kunde ge nya möjligheter att bygga mer hållbart. Betong är världens mest använda byggmaterial tack vare sin hållbarhet, formbarhet och motståndskraft mot fukt, mögel och brand. Men produktionConcrete is the most widely used construction material worldwide, with an annual global consumption of approximately 30 billion tons and 14–15 million tons in Sweden in 2022. Its popularity stems from its durability, robustness, formability, and resistance to moisture, mold,fire, and sound. However, concrete production has a significant environmental impact, largely due to cement manufacturing, wh

Background: To investigate a patient-level single imputation approach for patient reported outcomes (PROs) that express similar contents or associated PROs, where a PRO whose value is missing at a particular timepoint is substituted by another PRO whose value is available at the same timepoint. Methods: We performed a simulation study on registry-based spondyloarthritis data to explore the potenti

There is scientific consensus that limiting warming in line with the Paris Agreement goals requires reaching net zero CO2 emissions by mid-century and net negative emissions thereafter. Because of the entrenchment of current fossil fuel energy and feedstock demand estimated in almost all global modelled scenarios, 'abated' fossil fuel and industrial process and product use (IPPU) CO2 emissions, us