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The thesis of this paper is that it is possible to explain why a culpable aggressor forfeits his right not to suffer the harm necessary to prevent his aggression if a killer forfeits his right to life. I argue that this strategy accounts also for the necessity restriction on self-defense. I respond to several objections, including the worry that it makes no sense to attempt a derivation of the rel
Multiplex proteomic platforms provide excellent tools for investigating associations between multiple proteins and disease (e.g., diabetes) with possible prognostic, diagnostic, and therapeutic implications. In this study our aim was to explore novel pathophysiological pathways by examining 92 proteins and their association with incident diabetes in a population-based cohort (146 cases of diabetes
Aim: To evaluate whether history of pregnancy complications [pre-eclampsia, gestational hypertension, preterm delivery, or small for gestational age (SGA)] improves risk prediction for cardiovascular disease (CVD).Methods and results: This population-based, prospective cohort study linked data from the HUNT Study, Medical Birth Registry of Norway, validated hospital records, and Norwegian Cause of
Three episodes of mafic magmatism are identified by zircon and baddeleyite U-Pb dating at 2299 ± 17 Ma, 1703 ± 8 Ma and 1511 ± 14 Ma in the southwestern Yangtze Block. These mafic rocks have tholeiitic compositions with enrichment of LILE but an absence of Nb, Ta, Zr, Hf anomalies, features similar to E-MORB. They have La/Ta (<22) and La/Nb (<1.5) ratios similar to asthenosphere-derived mafic melt
Overall survival of patients with metastatic non-small cell lung cancer (NSCLC) has significantly improved with platinum-based salt treatments and recently with targeted therapies and immunotherapies. However, treatment failure occurs due to acquired or emerging tumor resistance. We developed a monoclonal antibody against the proform of neurotensin (LF-NTS mAb) that alters the homeostasis of tumor
InGaAs is a potential candidate for Si replacement in upcoming advanced technological nodes because of its excellent electron transport properties and relatively low interface defect density in dielectric gate stacks. Therefore, integrating InGaAs devices with the established Si platforms is highly important. Using template-assisted selective epitaxy (TASE), InGaAs nanowires can be monolithically
Objectives: Hepatic arterial treatment (HAT) for liver metastases in patients with metastatic breast cancer (MBC) has only been investigated in few studies. Materials and methods: Two phase II trials were initiated simultaneously to evaluate capecitabine in combination with oxaliplatin in patients with MBC and liver metastases. These two trials are reported together. Continuous capecitabine (1300
Arbuscular mycorrhizal fungi (AMF) are commonly present in wetlands, but their functional role there is not well understood. We have quantified the carbon (C) allocation from rice to AMF under different flooding regimes, using stable isotope labeling (13CO2), and assessed the potential phosphorus (P) delivery from AMF to rice by profiling the expression of plant and fungal P transporter genes. The
The purpose of decentralised solar district heating plants is to feed solar heat directly into district heating networks. This decentralised heat supply has to consider two major output conditions: a stable required feed-in supply temperature and a feed-in heat power equal to the heat output from the solar collectors. However, many installations cannot achieve the second output condition, since se
Dysregulation of autophagy has been observed in obesity and type 2 diabetes. Salt-inducible kinase 2 (SIK2), a member of the AMPK-related kinase family, is downregulated in adipocytes from obese or insulin resistant individuals and was previously demonstrated to regulate autophagy in cancer and normal cell lines. The aim of this study was thus to investigate a potential role of SIK2 in the regulat
Studies on short-term prognosis of venous thromboembolism (VTE) that take family history of VTE and Charlson Comorbidity Index (CCI) into account are sparse. The aim was to investigate the importance of family history of VTE and CCI for short-term mortality after a first episode of VTE. Using Swedish medical databases, we conducted a 90-day nationwide cohort study of 41,700 Swedish born patients w
Protein kinase RNA-activated (PKR) is a cytoplasmic receptor for dsRNA, and as such is involved in detection of viral infection. On binding dsRNA, PKR dimerizes, autophosphorylates, and then phosphorylates its substrate, eukaryotic translation initiation factor 2 subunit a (eIF2α), causing inhibition of mRNA translation and shutdown of viral protein production. However, active PKR has also been fo
Introduction: Conversion of androgen-responsive prostate cancer (CaP) to castration-resistant CaP) is associated with an acceleration of the disease that often requires treatment modalities other than androgen deprivation therapy only. Recently, follicle-stimulating hormone (FSH) has been shown to play a role in CaP growth, and clinical data showed that high serum concentration of FSH in chemicall
BACKGROUND/AIM: Cervical cancer is associated with poorer diagnosis among the elderly and pap-smear screening has a lower sensitivity. Self-sampling for detection of high-risk human papillomavirus (hr-HPV) may be an alternative screening method. The aim of this study was to analyze the response rate to vaginal HPV self-sampling and the HPV mRNA prevalence among women 69-70 years. MATERIALS AND MET
Continuous dopaminergic stimulation in Parkinson's disease (PD) has several advantages over pulsatile, noncontinuous, stimulation. These therapies currently consist of pump-based and transcutaneous therapies and are based on a more constant delivery of the dopaminergic drug resulting in continuous dopaminergic stimulation and a more stable treatment effect. Several clinical and experimental observ
Peninsular India is a collage of Archaean cratonic domains separated by Proterozoic mobile belts. A number of cratonic basins, known as “Purana basins” in the Indian literature, formed in different parts of the Indian Peninsula during extensional tectonic events, from Paleoproterozoic through Neoproterozoic times. In this contribution, we present a diversity of new geochronological data for differ
Since thermal loads can cause cracking, they are important to consider in bridge design. In order to evaluate and develop thermal load cases based on real simulations, models for simulating temperatures can be used. In this paper, a model for thermal simulation is used to simulate temperature in a portal frame bridge outside Lund, Sweden. The results are compared with temperature measurements in 1
