BackgroundWith advancing age the brain becomes more sensitive to centrally acting drugs thus increasing the risk of cognitive side-effects. The Swedish National Board of Health and Welfare developed indicators to measure and follow quality in older people's drug therapy, one being “Potentially Inappropriate Medications risking Cognitive impairment (PIMcogn)”. Associations between anticholinergics

Cognitive semiotics is understood here to consist in the merger of the two great transdisciplinary endeavours (re)emerging in the middle of the last century, semiotics and cognitive science, the common core of which may consist in the phenomenological perspective, in both Husserl’s and Peirce’s sense of the term. We explore and revise Louis Prieto’s characterization of the semiotic sciences, traci

In Krisis, and in many of the preparatory papers for his last published work, Edmund Husserl repeatedly declares his allegiance to the Enlightenment, but, at the same time, always expresses his misgivings about its concrete purport. Like Horkheimer and Adorno, but for somewhat different reasons, he thus succumbs to what Ferrone has termed the philosopher’s conception of the Enlightenment, as opposIn Krisis, and in many of the preparatory papers for his last published work, Edmund Husserl repeatedly declares his allegiance to the Enlightenment, but, at the same time, always expresses his misgivings about its concrete purport. Like Horkheimer and Adorno, but for somewhat different reasons, he thus succumbs to what Ferrone has termed the philosopher’s conception of the Enlightenment, as oppos

In 1981 appeared my first published paper, with the title, “A plea for integral linguistics”,which summarized the epistemological stance of my 1978 doctoral dissertation. In a lecture given in Bucharest, published only in 2004, Coseriu said that he very belatedly, in 1981, applied the term “integral linguistics” to his conception of linguistics. There is an enormous difference between a young scho

Emily Skop, Martina Angela Caretta, Caroline Faria and Jessi L. Smith offer other scholars engaged in research collaborations a pledge to help foster and sustain more equitable relationships.

As the COVID-19 pandemic continues to affect societies across the world, the ongoing economic and social disruptions are likely to present fundamental challenges for current and future biodiversity conservation. We review the literature for outcomes of past major societal, political, economic and zoonotic perturbations on biodiversity conservation, and demonstrate the complex implications of pertu

In this paper we target the color transfer estimation problem, when we have pixel-to-pixel correspondences. We present a feature-based method, that robustly fits color transforms to data containing gross outliers. Our solution is based on an optimal inlier maximization algorithm that maximizes the number of inliers in polynomial time. We introduce a simple feature detector and descriptor based on

In this paper we present a unified formulation for a large class of relative pose problems with radial distortion and varying calibration. For minimal cases, we show that one can eliminate the number of parameters down to one to three. The relative pose can then be expressed using varying calibration constraints on the fundamental matrix, with entries that are polynomial in the parameters. We can

SKINNY is a lightweight tweakable block cipher which received a great deal of cryptanalytic attention due to its elegant structure and efficiency. Despite the cryptanalytic efforts the security margins are remaining high. This has led to SKINNY being used as a component of multiple submissions in the NIST Lightweight Competition, an effort to standardize a lightweight AEAD scheme. Inspired by the

Based on an interdisciplinary investigation of future visions, scenarios, and case-studies of low carbon innovation taking place across economic domains, Decarbonising Economies analyses the ways in which questions of agency, power, geography and materiality shape the conditions of possibility for a low carbon future. It explores how and why the challenge of changing our economies are variously as

Aerosol particles, small solid or liquid particles suspended in a gas, are found everywhere in the atmosphere. Air pollution from such particles, mainly soot from combustion-derived activity is a leading cause of premature deaths in the world and have a large effect on the climate. Aerosol particles can interact with climate-related processes in the atmosphere either directly by absorbing or refle

Introduction: Smoking may reduce the efficacy of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD), but its impact on bronchodilator efficacy is unclear. This analysis of the EMAX trial explored efficacy and safety of dual- versus mono-bronchodilator therapy in current or former smokers with COPD. Methods: The 24-week EMAX trial evaluated lung function, sy

BACKGROUND: In recent years, telemedicine consultations have evolved as a new form of providing primary healthcare. Telemedicine options can provide benefits to patients in terms of access, reduced travel time and no risk of disease spreading. However, concerns have been raised that access is not equally distributed in the population, which could lead to increased inequality in health. The aim of

Solid-state klystron modulators are typically based on oil-immersed high-voltage (HV) pulse transformers because of their high performance, robustness, simplicity, and straightforward design. However, pulse transformer size is fundamentally linked to application pulse length, pulse power, and pulse rise time. For high-power applications transformer size quickly becomes very problematic when approa

Rapeseed press cake (RPC), the by-product of rapeseed oil production, contains proteins with emulsifying properties, which can be used in food applications. Proteins from industrially produced RPC were extracted at pH 10.5 and precipitated at pH 3 (RPP3) and 6.5 (RPP6.5). Emulsions were formulated at three different pHs (pH 3, 4.5, and 6) with soy lecithin as control, and were stored for six month

Living with relatives can be highly beneficial, enhancing reproduction and survival. High relatedness can, however, increase susceptibility to pathogens. Here, we examine whether the benefits of living with relatives offset the harm caused by pathogens, and if this depends on whether species typically live with kin. Using comparative meta-analysis of plants, animals, and a bacterium (nspecies = 56