Lysozyme is a model system for crystallographers. In this issue of Structure, Ramos et al. report atomic resolution neutron structures of lysozyme, which unambiguously show the protonation states and hydrogen-bonding networks of the active site. This resolves mechanistic questions that have been debated for decades and provides a unique view to a protein at atomic detail.

To address the challenges of energy transition necessary for sustainable development, incumbents must implement innovations, some of which are radical compared with their current competence-base or market solutions. This requires a thorough understanding of the prerequisites for implementing innovation. The literature on the factors influencing incumbents' implementation is vast and dispersed acro

OBJECTIVES: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive adjunct to multimodal pain management for acute postoperative care across various surgeries. Despite extensive evidence supporting its efficacy, TENS remains underutilized in clinical practice. This study aimed to assess the knowledge, attitudes, and practices of healthcare professionals regarding TENS in perioperative

Multivariate random sums appear in many scientific fields, most notably in actuarial science, where they model both the number of claims and their sizes. Unfortunately, they pose severe inferential problems. For example, their density function is analytically intractable, in the general case, thus preventing likelihood inference. In this paper, we address the problem by the method of moments, unde

Solar drying, utilizing solar energy to extract moisture from foodstuff, is a highly effective method for extending the shelf life of for instance fruits and vegetables. The utilization of solar dryers brings numerous benefits, e.g., it reduces reliance on fossil fuels and electricity and establishing an environmentally sustainable and relatively cheap option for food preservation. In this researc

I denna artikel undersöks hur hemtjänsten påverkar äldre personer i Sverige, med fokus på hur den på ett subtilt sätt kan institutionalisera deras dagliga liv. Hemtjänsten visar sig ha en inverkan på brukarnas individualitet och självständighet, i motsats till de ursprungliga intentionerna att erbjuda ett frigörande alternativ till vårdinrättningar.I studien används Goffmans begrepp ”totala instit

Glenn Möllergren reflekterar i kapitel 7 över riktlinjer och deras konsekvenser utifrån erfarenheterna från sin verksamhetsförlagda termin på socionomprogrammet. Han använder professionsteorins grunder för att ställa frågan om vart lojaliteten bör riktas i användandet av riktlinjer: Är det mot omsorgsmottagaren eller mot skattebetalarna? Utifrån samma teoretiskautgångspunkter resonerar han kring v

With growing environmental concerns, upcycling has become an important theme in literature and practice. Upcycling can help slow and close resource cycles through product life-extension. Cities offer opportunities for upcycling initiatives and seek to tackle challenges in urban solid waste management by encouraging entrepreneurs to create value from local waste streams in urban resource centres an

Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy against breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction of apoptosis, and suppressing angiogenesis, positioning it as a

Invertebrate embryos have relatively low fossilization potential; however, when preserved, they can offer crucial insights into the evolutionary developmental biology of extinct animals. Here we report new exceptionally preserved fossil embryos from the early Fortunian (early Cambrian) of China, which are assigned to two new taxa, Saccus xixiangensis gen. et sp. nov. and Saccus necopinus gen. et s

Få saker skrämmer människor så mycket som att förlora minne och identitet. Detta är dock en realitet för många som lever med demens. I bokens åttonde kapitel undersöker Glenn Möllergren de levnadsbe-rättelser som numera används inom äldreomsorgen för att kunna stödja individer och ge en god personcentrerad omsorg. I sin genom-gång visar Möllergren att det finns en stor variation i utformningen av

Hypothesis: Low-frequency Raman (LFR) spectroscopy is proposed as a novel non-destructive methodology to probe pH-related phase transitions in self-assembled lipid particles. In this case, dispersed lipid mesophases were composed of ionisable oleic acid (OA) or nicergoline (NG) in monoolein (MO). The sensitivity of LFR spectroscopy to low-energy intermolecular vibrations was hypothesised to be due

To solve the problem of fatigue of the UAV operator during long-term search and reconnaissance missions, a research hardware and software complex was created, in which the positioning of the auxiliary UAV video camera with a narrow field of view is carried out. Dynamixel Library for MATLAB and Simulink was used to organize the interaction of actuators with the virtual environment, which allows com

Purpose: Although total dietary protein intake has been associated with bladder cancer (BC) risk, the effect of the origin (plant or animal) and the substitutions remain to be understood. This study aimed to investigate the effect of total dietary protein, animal-based protein, plant-based protein, and their substitutions with each other on the risk of BC using a pooled analysis of 10 cohort studi

New antimicrobial and anti-inflammatory therapeutics are needed because of antibiotic resistance development and resulting complications such as inflammation, ultimately leading to septic shock. The antimicrobial effects of various nanoparticles (NPs) are currently attracting intensive research interest. Although various NPs display potent antimicrobial effects against strains resistant to convent

The accurate representation of mixed-phase monsoon clouds and their phase distribution is of great importance for numerical models used to predict monsoon rainfall. Therefore, it is essential for these models to correctly capture the phase fraction of clouds, which includes the proportions of liquid and ice. Ice particle formation in clouds occurs through primary ice production and secondary ice p

To increase the utilisation rate of the power system and accelerate electrification while providing a high degree of security and reliability, System Integrity Protection Schemes (SIPS) are of great importance. SIPS functions are automatic remedial actions, detecting abnormal conditions or contingencies in the system and taking control action to mitigate these conditions. Design, implementation, m

The aim of this thesis was to investigate the interactions between the kallikrein-kinin system (KKS) and the complement system during vascular inflammation and the contribution of extracellular vesicles (EVs). Vasculitis, in patients and in experimental models, was studied as a prototype inflammatory disease of the vasculature.Papers I and II addressed the impact KKS signalling has on complement a

2-amino-2-methyl-1-propanol (AMP) in dimethyl sulfoxide (DMSO) is a precipitating non-aqueous amine technology that can potentially lower the energy demand during CO2 removal from industrial flue gases compared to aqueous amine technologies. However, DMSO is hygroscopic and has a high possibility of absorbing water from humid flue gases, which can affect the physical properties of the system,