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Background: This study evaluated the characteristics of subependymal giant cell astrocytoma (SEGA) in patients with tuberous sclerosis complex (TSC) entered into the TuberOus SClerosis registry to increase disease Awareness (TOSCA). Methods: The study was conducted at 170 sites across 31 countries. Data from patients of any age with a documented clinical visit for TSC in the 12 months preceding en
Kulturmiljöer som historiska byggnader, stenmurar, diken och alléer är värdefulla delar av vårt kulturarv. Om miljöerna ska bevaras krävs att ersättningen för skötsel av dem är så pass attraktiv att många väljer att ansluta sig. Förutom nivån på den ekonomiska ersättningen finns en rad faktorer som spelar roll för viljan att ansluta sig, och vissa av dessa kan stimuleras av så kallad nudging.Denna
OBJECTIVE: To determine the effects of oxygen therapy in myocardial infarction (MI) patients with and without diabetes. RESEARCH DESIGN AND METHODS: In the Determination of the Role of Oxygen in Suspected Acute Myocardial Infarction (DETO2X-AMI) trial, 6,629 normoxemic patients with suspected MI were randomized to oxygen at 6 L/min for 6-12 h or ambient air. In this prespecified analysis involving
BACKGROUND: A new generation of positron emission tomography with computed tomography (PET-CT) was recently introduced using silicon (Si) photomultiplier (PM)-based technology. Our aim was to compare the image quality and diagnostic performance of a SiPM-based PET-CT (Discovery MI; GE Healthcare, Milwaukee, WI, USA) with a time-of-flight PET-CT scanner with a conventional PM detector (Gemini TF; P
Metastatic behavior varies significantly among breast cancers. Mechanisms explaining why the majority of breast cancer patients never develop metastatic outgrowth are largely lacking but could underlie the development of novel immunotherapeutic target molecules. Here we show interplay between nonmetastatic primary breast cancer and innate immune response, acting together to control metastatic prog
Importance: Preterm birth has been associated with cardiometabolic, respiratory, and neuropsychiatric disorders in adulthood. However, the prevalence of survival without any major comorbidities is unknown. Objective: To determine the prevalence of survival without major comorbidities in adulthood among persons born preterm vs full-term. Design, Setting, and Participants: National cohort study of a
BACKGROUND: Gout is the most common inflammatory arthritis with a rising prevalence around the globe. While educational inequalities in incidence and prevalence of gout have been reported, no previous study investigated educational inequality in mortality among people with gout. The aim of this study was to assess absolute and relative educational inequalities in all-cause and cause-specific morta
The limits of the environmental state in the context of the provision of economic growth are addressed by applying materialist state theory, state-rescaling approaches and the degrowth/postgrowth literature. I compare state roles in a capitalist growth economy and in a postgrowth economy geared towards bio-physical parameters such as matter and energy throughput and the provision of ‘sustainable w
The urban water crisis, including issues of water scarcity, pollution and flooding, is one of the key challenges for sustainable urban development. Reasons are manifold. Preventive measures are for instance being put on the back burner, while re-active measures and siloed governance are daily business, resulting in power struggles and ineffective governance. As the water crisis hits the most vulneWe are in the midst of a water crisis. Scarcity, pollution and flooding are some of today’s key challenges for sustainable urban development. The reasons are manifold. Preventive measures are put on the back burner, while reactive measures, siloed governance approaches and power struggles are daily business, resulting in ineffective governance. The crisis is hitting the most vulnerable urban popul
Antalet allvarliga konsekvenser av katastrofer i världen har ökat, vilket lett till ett internationellt initiativ för att främja utvecklingen av nationella strategier för katastrofriskreducering (DRR) och resiliens. Ett av de globala målen i Sendairamverket för katastrofriskreducering 2015-2030, antaget av FN:s medlemsstater, handlar om att länderna ska ta fram strategier kopplat till DRR (mål E).Increasing impacts from hazards worldwide, including Sweden, have prompted international efforts to promote the development of national strategies for disaster risk reduction (DRR) and resilience to reduce associated impacts and support sustainable development. The development of such strategies is global target E of the Sendai Framework for DRR 2015-2030, which was adopted in 2015 by Sweden and o
This chapter starts off in communication geography and discuss the dynamic relationship between media and place. The main argument is that processes of mediation are central to the meaning of place although without determination; mediations may both strengthen and weaken boundaries of place. This argument is based on an interdisciplinary double theorization where the concept of place as well as me
DN DEBATT 30/3. Översvämningar lyfts ofta som klimatfrågor eller som behov av skydd mot extrema väderhändelser. Då glöms andra viktiga orsaker bort, som hur vi använder marken och utvecklar bebyggelse. Tyvärr finns stora problem med styrningen av vattenhanteringen i dag, som bidrar till att skapa problem i stället för att förebygga dem, skriver åtta vattenexperter.
DebattTillgången till vatten kan inte längre ses som en lokal fråga utan måste ses ur ett bredare perspektiv, som kräver en samordning som är ny för Sverige. Det behövs sammanhängande nationell styrning och en strategi med helhetssyn på vattenfrågan, skriver nio svenska vattenexperter som kommer att debattera detta ämne under politikerveckan i Almedalen.
På senare år har flera studier visat på att järnhalten ökar i sjöar och vattendrag i norra Europa. Järn spelar en nyckelroll i akvatiska miljöer genom att påverka tillgängligheten av andra näringsämnen i vattnet så som kväve och fosfor, vilket kan reglera tillväxten av växtplankton. Dessutom färgar järn tillsammans med organiskt material vatten brunt. När vattnet blir brunare försämras ljusklimateIron (Fe) concentrations are increasing in freshwaters (lakes and streams) in Sweden, as well as in other regions in northern Europe. Together with increasing concentrations of organic matter, Fe is contributing to the ongoing browning of freshwaters, which may have serious ecological consequences and implications for ecosystem services. The aim of this thesis was to investigated where, to what ex
Uppsats som behandlar mina erfarenheter som deltagande sångpedagog i Cecilia Hultbergs internationella forskningsprojektet VÄL( Vem äger lärandet) - Student´s ownership of learning.
Hjärt-kärlsjukdom är den vanligaste dödsorsaken i världen. Tidig diagnos och individanpassad vård är viktigt för att kunna behandla hjärtsjuka patienter. Ny teknik kan möjliggöra framtagandet av nya och förbättrade underlag som behövs för diagnos och behandlingsplan av många hjärtsjuka patienter. Därför har nya analysverktyg som utökar mängden fysiologisk information som går att utvinna ur en endaThe assessment of cardiovascular physiology is crucial to facilitate clinical diagnostics, treatment, and research. Physiology and anatomy can be assessed noninvasively using cardiovascular magnetic resonance (CMR), a versatile and reliable medical imaging modality free from ionizing radiation. CMR is capable of providing a vast amount of information such as displacement, velocity, flow, length, a
