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A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.

BACKGROUND AND AIMS: Autoantibodies against the zinc transporter 8 (ZnT8A) are common in type 1 diabetes (T1D). ZnT8A analyses are complicated by the fact that there are three variants of the autoantigen at amino acid position 325 representing ZnT8-R (Arginine), ZnT8-W (Tryptophan) and ZnT8-Q (Glutamin). The aims of the study were: 1) to develop an autoantigen triple mix Radio-Binding Assay (RBA)

Shaping up a lineage-lessons from B lymphopoesis.

Even though the development of B lymphoid cells from hematopoietic stem cells is one of the most carefully investigated models of cell differentiation in adult mammalians, a set of recent findings has to a large extent increased our understanding for how B lymphoid commitment is achieved. These include the identification of IKAROS, PU.1 and E2A as transcription factors responsible for lymphoid lin

Sense of Touch in Robots

This thesis discusses a number of robot touch perception systems. All these systems are self-organizing and model different aspects of human touch perception. The thesis starts out with introductions to the anatomy and the physiology of the human hand. It proceeds with an overview of the human touch perception from both a neurophysiological and a behavioural perspective. Then related robotic resea

Torque-maximizing field-weakening control: design, analysis, and parameter selection

The torque-maximizing field-weakening control scheme proposed by Kim and Sul is developed further. The performance under imperfect field orientation conditions is investigated, and it is shown that an overestimated-rather than an underestimated-model leakage inductance should be used. A slightly modified algorithm, which offers better robustness and reduced computational complexity, is presented.

Non-invasive estimation of glomerular filtration rate (GFR). The Lund model: Simultaneous use of cystatin C- and creatinine-based GFR-prediction equations, clinical data and an internal quality check.

Abstract Knowledge of glomerular filtration rate (GFR) is required to detect and follow impairment of renal function, to allow correct dosage of drugs cleared by the kidneys, and for the use of nephrotoxic contrast media. Correct determination of GFR requires invasive techniques, which are expensive, slow and not risk-free. Therefore, GFR-prediction equations based solely upon cystatin C or creati

Hyperdense middle cerebral artery sign in multidetector computed tomography: Definition, occurrence, and reliability analysis.

Background: The hyperdense middle cerebral artery sign (HMCAS) is one of the early changes seen on the computed tomography in acute ischemic stroke of MCA territory. Aims: To evaluate the reliability of subjective evaluation of HMCAS on CT performed at multidetector CT (MDCT) and evaluated in the Picture Archiving Communication Systems, to define objective criteria for HMCAS and to find out if the

The Challenges of Provisioning Real-Time Services in Wireless Internet

The issues involved in supporting real-time wireless Internet services go beyond the problem of forwarding packets to the correct destination of a mobile host. These issues include handover latency, availability of network resources after moving, and a proper charging and accounting infrastructure. Through a survey of current research in these areas, we discuss various concerns of integrating mobi