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We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re
Industrial catalysts are complex materials systems operating in harsh environments. The active parts of the catalysts are nanoparticles that expose different facets with different surface orientations at which the catalytic reactions occur. However, these facets are close to impossible to study in detail under industrially relevant operating conditions. Instead, simpler model systems, such as sing
Objective: To describe outcomes after elective and non-elective fenestrated-branched endovascular aortic repair (FB-EVAR) for thoracoabdominal aortic aneurysms (TAAAs). Background: FB-EVAR has been increasingly utilized to treat TAAAs; however, outcomes after non-elective versus elective repair are not well described. Methods: Clinical data of consecutive patients undergoing FB-EVAR for TAAAs at 2
A search for pair-produced scalar and vector leptoquarks decaying into quarks and leptons of different generations is presented. It uses the full LHC Run 2 (2015–2018) data set of 139 fb−1 collected with the ATLAS detector in proton–proton collisions at a centre-of-mass energy of s = 13 TeV. Scalar leptoquarks with charge −(1/3)e as well as scalar and vector leptoquarks with charge +(2/3)e are con
I have come to notice that the outcomes of the dialogue with the audience is crucial for the improvisational communication between me and the pianist in Impromans, Conny Antonov. This has very much to do with the room of the performance, and its implicated expectations and discourses. As improvisation is very dependent on the context of the room, Antonov and I decided to explore performing in a mo
The chapter focuses on a foundational text in the fields of media and communication history, book history, and print culture studies: Elizabeth L. Eisenstein’s comprehensive two-volume work, The Printing Press as an Agent of Change, first published in 1979. Apart from outlining Eisenstein’s key perspectives, arguments, and findings, the chapter brings up the historical and scholarly context in whi
Non-exhaust sources, such as brakes, tyres, roads, and clutches, emit a large portion of airborne particles in road transportation, from ultrafine to coarse sizes. While airborne wear particle emissions from brakes and road-tyre contacts have been studied extensively, emissions from clutches have been overlooked. A preliminary study using a novel test rig has indicated that dry clutches also emit
While previous scholarship has shown that the rhetorical figure of the "heretical woman"was important in Jerome's slandering of male rivals, this article argues that the "orthodox woman"played a just as important role in his self-presentation as an orthodox teacher. The "orthodox woman"is characterized by true asceticism which, according to Jerome's ascetic theology, implies that she transcends he
Background: Interactions between moss species in their earliest growth stages have received little attention. To what extent interspecific competition or priority effects influence spore germination, protonemal development and gametophore emergence is unknown. We evaluated such effects in pairwise interaction between six common bryophyte species: Atrichum undulatum, Bryum argenteum, Ceratodon pur
Context. The origin and evolution of fluorine in the Milky Way Galaxy is still under debate. In particular, the increase in the [F/Fe] in metal-rich stars found from near-IR HF lines is challenging to explain theoretically. Chemical evolution models with current knowledge of yields from different fluorine-producing stellar sources cannot reproduce these observations.Aims. The aim of this work is t
Artikeln beskriver hur en grammatikdidaktisk modell utformad för en L1-kontext kan användas för grammatikundervisning såväl som för ett språk- och skrivutvecklande arbete i en L2-kontext. Eftersom klassrummen i Sverige, Danmark och Norge allt mer blir språkligt heterogena behöver lärare kunna erbjuda en språkutvecklande under-visning för elever med skilda språkliga förutsätThe article shows how a grammar-didactic model designed for an L1 context can be used for grammar learning as well as language and writing development in an L2 con-text. Because classrooms in Sweden, Denmark and Norway are becoming increasingly heterogenous, teachers must be able to develop the language of pupils with differing linguistic predispositions. The model that
This study investigates people’s associations between the exchange of sexual services for payment and different sexual activities. Sex work entails a range of activities, from in person services to online performances. To date, no study has asked about the activities individuals associate with the exchange of sexual services for payment. The relationship between the exchange of sexual services for
Background: We investigated all-cause and epilepsy-related mortality in patients operated with resective epilepsy surgery and in non-operated patients with drug-resistant epilepsy. Our hypothesis was that patients who proceed to surgery have lower mortality over time compared with non-operated patients. Method: Data from 1329 adults and children from the Swedish National Epilepsy Surgery Register
A wide range of literatures have identified the capitalist organisation of societies, and the capitalist growth imperative central to this organisation, as the root cause of the catastrophic climate and biodiversity crises. Highlighting the need to break with this imperative, a growing community of scholars generally viewed as anti- and postcapitalist, there is no consensus on how precisely to con
BACKGROUND: Genomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and non-coding RNAs. In some cancer types, fusions involving specific kinases are used as targets for therapy. Fusion genes can be detected by whole genome sequencing (WGS) and targeted fusion panels, but RNA sequencing (RNA-Seq) has the advantageous capability
The discussion on the Anthropocene has increased the urgency to promote a sustainable society, considering the planetary boundaries, population growth and resource scarcity. Thus, the United Nations created the 2030 Agenda for Sustainable Development to address this challenge, including 17 Sustainable Development Goals (SDGs) and 169 SDG targets. In this context, the energy sector is one of the ma
Potential harm to human rights and the environment, including by corporate actors, is amplified in situations of conflict. This article focuses on applying the right to a healthy environment in relation to armed conflicts and corporate responsibility. In particular, it analyzes and compares due diligence requirements in the European Union Conflict Minerals Regulation and the International Law Comm
