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Vibrational states of Zn-meso-indolo[3,2-b]carbazolyl-substituted porphyrins: Fluorescence line narrowing study

Highly resolved vibrational spectra for the Zn-complexes of several meso-substituted tetraarylporphyrins were recorded by fluorescence line narrowing (FLN) method at liquid helium temperature. The frequencies of the vibronic lines of the Zn-5,10,15,20-tetraphenylporphyrin (ZnTPP), the Zn-5,10,15,20-tetramesitylporphyrin (ZnTMesP) and four meso-indolocarbazolyl-substituted porphyrin compounds in th

Cell and gene therapy for blood disorders. Modeling of novel treatment strategies for Gaucher type 1 disease and Diamond-Blackfan anemia in mice.

Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. Currently, bone marrow transplantatio

Endotoxins in Environmental and Clinical Samples Assessed by GC-Tandem MS

Bacteria appeared on the Earth millions years before us and human evolution was triggered by the constant presence of pathogenic and symbiotic microorganisms in our surroundings. Interplay occurred between higher organism and microbial consortia residing in the host organs and on the epithelial surfaces; another natural space of bacteria human interaction is the indoor environment where we spend t

Control-Quality Driven Design of Cyber-Physical Systems with Robustness Guarantees

Many cyber-physical systems comprise several control applications sharing communication and computation resources. The design of such systems requires special attention due to the complex timing behavior that can lead to poor control quality or even instability. The two main requirements of control applications are: (1) robustness and, in particular, stability and (2) high control quality. Althoug

Description of new specimens of Halisaurus arambourgi BARDET & PEREDA SUBERBIOLA, 2005 and the relationships of Halisaurinae

Halisaurine mosasaurs are poorly known, represented by a small number of specimens from the Santonian-Maastrichtian (similar to 86 Ma - similar to 66 Ma), but enjoyed broad palaeobiogeographic distribution during that time. They are important for understanding mosasaur evolution because certain aspects of their morphology retain the relatively plesiomorphic or minimally modified squamate condition

Design of new multipass gas cells with circular and elliptical cross-section

Two new types of multipass gas cells with circular and elliptical cross-sections were developed. As for a cylindrical cell, the reflected rays in the circle would be an irregular trace without superposition and termination, if its central angle is a bit more than 2 pi/3 for an example. Each two adjacent reflected points have the same optical path difference and optical light passes through differe

Reduced diversity and changed bacterioplankton community composition do not affect utilization of dissolved organic matter in the Adriatic Sea

To obtain insights into the coupling between community composition, diversity and community function, bacterioplankton assemblages from the Gulf of Trieste (Northern Adriatic Sea) were exposed to increasing environmental stress throughout 2 wk in continuous seawater cultures to construct communities differing in composition and diversity. The assemblages were exposed to (1) decreased temperature,

Quantitative hydrogen analysis in minerals based on a semi-empirical approach

Hydrogen normally occurs as hydroxyl ions related to defects at specific crystallographic sites in the structures, and is normally characterized by infrared spectroscopy (FTIR). For quantification purposes the FTIR technique has proven to be less precise since calibrations against independent methods are needed. Hydrogen analysis by the NMP technique can solve many of the problems, due to the low

The strength of species interactions modifies population responses to environrnental variation in competitive communities

The life-history parameters of most living organisms are modified by fluctuations in environmental conditions. The impact of environmental autocorrelation on population persistence is well understood in single species systems. However, in multi-species communities the impact of stochasticity is complicated by the possibility of different species having differing intrinsic responses to the environm

Multiannual hydrological responses in Scots pine radial growth within raised bogs in southern Sweden

To explore interactions between climate and peatland hydrology, Scots pine (Pinus sylvestris L.) growing at four raised bogs in southern Sweden were subject to a dendroclimatological study. Radial tree growth reflecting climate and water table fluctuations over multiannual periods was detected as significant negative correlations between tree-ring width (TRW) chronologies and the preceding one to

Reduced tonsillar expression of human β-defensin 1, 2 and 3 in allergic rhinitis.

Airway infections are known to cause exacerbations of allergy and asthma. Tonsils constitute a primary site for microbial recognition and triggering of the immune system in the airways. Human β-defensins (HBDs) are antimicrobial peptides with an important role in this defense. Our aim was to investigate HBD1-3 in tonsillar tissue and their potential role in allergic rhinitis (AR). Tonsils, obtaine

Arguments for considering uncertainty in QSAR predictions in hazard and risk assessments.

Chemical regulation allows non-in vivo testing (i.e. in silico-derived and in vitro-derived) information to replace experimental values from in vivo studies in hazard and risk assessments. Although non-in vitro testing information on chemical activities or properties is subject to added uncertainty as compared to in vivo testing information, this uncertainty is commonly not (fully) taken into acco

An exploratory investigation of the elements of B2B brand image and its relationship to price premium

Much of the extant work on brand equity in business markets has focused on predicting brand loyalty as in what brand image elements that make buyers prefer to buy a brand The question what drives buyers to pay more or less for brands has however been somewhat overlooked despite price premium being a distinct and economically important outcome of a favourable brand image In an attempt to answer thi

TOA sensor network self-calibration for receiver and transmitter spaces with difference in dimension

We study and solve the previously unstudied problem of finding both transmitter and receiver positions using only time of arrival (TOA) measurements when there is a difference in dimensionality between the affine subspaces spanned by receivers and transmitters. Anchor-free TOA network calibration has uses both in radio, radio strength and sound applications, such as calibrating ad hoc microphone a