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Cancer orsakar en sjättedel av alla dödsfall världen över. Varje år diagnostiseras omkring 20 miljoner människor, varav 400 000 är barn. De läkemedel som finns idag är inte alltid effektiva och dessutom finns det inte läkemedel för alla typer av cancer. Det är därför väsentligt att det konstant utvecklas nya cancerläkemedel. I våra celler finns proteinet galektin som är inblandat i många av cellToday, galectin-1 poses as an interesting drug target for novel cancer treatments, due to its involvement in cancer progression. MD simulations with a 3-(thiazole-triazolyl)-galactoside, a good galectin-1 inhibitor, and the target protein reveals an unoccupied binding pocket close to the inhibitor. This project therefore aims to perform a bio-orthogonal C-H functionalisation on position 5 of its t

Inverter-based resources are playing an increasingly important role in power systems. However, the ability of inverter-based resources to deliver short-circuit currents is very limited, and often lies in the range of 1.2 to 2 p.u. for current power modules. This range is considerably lower when compared to that of synchronous generators, yielding short-circuit currents between 6 to 8 p.u. The diff

The coupled climate and nature crisis requires rapid mitigation that does not compromise biodiversity. Forests have the potential to improve environmental objectives in synergies depending on management. To better understand the motivations behind forest management practices among non-industrial private forest (NIPF) owners in Sweden, this study conducted a cross-sectional comparative analysis wit

In order to solve planetary health, the human-nature relationship has to be understood in more detail. Therefore, the current study aimed to validate and assess construct, convergent, divergent, and predictive validity of the Nature Disconnectedness Scale. Using data from 312 participants in Sweden, confirmatory factor analyses found support for a structure consisting of three dimensions and eight

This thesis explores how a sustainable future for the Sinharaja forest reserve might be achieved. Sinharaja is the largest remaining tract of ancient rainforest in Sri Lanka, home to a diverse array of flora and fauna, the majority of which are endemic. While conservation efforts initiated by the Sri Lankan government provide a promising framework for protecting this unique landscape, challenges

Vatten är nödvändigt för att den mänskliga kroppen ska fungera. För att vattnet ska kunna transporteras in och ut ur cellerna behöver det komma igenom cellmembranet, vilket det bland annat gör via en särskild klass av proteiner som fungerar som vattenkanaler – akvaporinerna. Akvaporiner finns överallt i vår kropp och är viktiga för många biologiska funktioner såsom metabolism och återfuktning av hAquaporins (AQPs) are a family of transmembrane proteins, mainly mediating water transport over the cell membrane in various parts of the body. The aquaporins AQP3 and AQP7 are both part of the subfamily aquaglyceroporins, which apart from water conduct small non-polar solutes such as glycerol. AQP3 overexpression or malfunction has been connected to skin and lung cancer and potential AQP3 inhibit

An optical system for digital light processing car headlamps was designed and optimized in this project. The specifications include five lens elements and a field of view of 15 degrees horizontally and 7.5 degrees vertically. The system consists of an illumination module and a projection lens assembly. A high-brightness LED source and a rectangular light integrator ensure uniform illumination on t

Purpose: This study aims to contribute to the understanding of how job-seekers relate their negative recruitment process experiences to brands. Design/Methodology/Approach: This study adopts a qualitative approach using semi-structured interviews, conducted with thirteen current university students actively seeking employment in degree-requiring fields. The data is abductively analysed through th

This thesis explores a hybrid procedural animation framework that combines physics-based constraints with artistically tunable parameters to generate diverse, real-time character locomotion. Addressing the limitations of traditional keyframing and opaque data-driven methods, the system employs a hierarchical parameter set-ranging from high-level style descriptors (e.g., "energy level") t

The primary task of child forensic interviewers is to secure evidence without causing the child discomfort. Evidence obtained through incorrect interview techniques risks being denied in court. Research has shown that negative emotions such as sadness and anger can affect the interrogation negatively. The aim of this study was to gain new knowledge about the complexity that child interviewers face

This study explores consumer perceptions of heritage brands following a revolutionary rebrand, with a focus on adapting the Consumer Perceived Value (CPV) theory. Building on Wuestefeld et al.’s (2012) framework, the research incorporates the disruptive nature of revolutionary rebranding to extend the theoretical understanding of CPV in a heritage branding context. Guided by a relativist ontology

I Sverige har var femte ungdom mellan 16-24 år blivit utsatt för våld i en parrelation. Denna uppsats behandlar det sexuella och fysiska våld som flickor utsätts för i parrelationer motiverat utifrån att statistiken visar att det är en grupp som särskilt drabbas av dessa våldsformer. Syftet är att bidra med kunskap eftersom den svenska forskningen inom fältet är mycket begränsad. Förhoppningen är

This thesis explores the phenomenon of employee ambassadorship in the public sector within the framework of internal branding. The aim is to identify the factors that facilitate or hinder employee ambassadorship, particularly on an individual and organizational level. The study challenged the dominant managerial perspective on internal branding by establishing an employee-centered approach which r

Purpose: This study aims to investigate how consumer attitudes toward AI-generated content, in the form of pictures and videos, shape how they perceive a brand’s image. Research question: How is consumers’ perception of a brand’s image shaped by the use of AI-generated visual content? Theoretical Framework: Breckler’s ABC model, which conceptualizes the notion of attitudes, is used to ensure we

Purpose: The study aims to examine whether health consciousness, as a cognitive heuristic, influences the impact of vegan labels, as external cues, on product attribute perceptions such as taste, health, and environmental friendliness, as well as on consumption intentions. As consumers face cognitive limitations when evaluating food products, this research aim to contribute to the understanding of

Fatima, f, 34, parent: “It is a small home for our children. They spend many hours here. To us, it is not just daycare. We don’t just come here and drop off our children and say goodbye, then come back in a few hours. They have to feel that this is a home to them”. This ethnographic study of Danish daycares analyses how information is being shared between parents and daycare staff, how conflict is

This study investigates the relationship between public perceptions of rape myths, secondary victimization, and the willingness to report a sexual assault in a Swedish context. A literature review was conducted to map the current state of the research, which revealed that most previous studies originate from North America and emphasize the role of institutional responses, especially by the police.

As climate change accelerates, rising sea levels and eroding shorelines are reshaping our coastal landscapes. Short-term fixes, such as beach nourishment and offshore breakwaters, are proving increasingly ineffective and costly. In nations like Sri Lanka, where tourism is a vital pillar of the economy and heavily dependent on beaches, these transient measures have become financially unsustainable.

Selection bias in non-probability samples presents a significant challenge in IoT device di- agnostics data analysis, where incomplete or systematically missing data can compromise the validity of analytical insights. Our project proposes a comprehensive statistical frame- work to correct for that bias, using real-world data from Axis Communications AB. The project explores three primary methodolo