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Glycobiology is dogged by the relative scarcity of synthetic, defined oligosaccharides. Enzyme-catalysed glycosylation using glycoside hydrolases is feasible but is hampered by the innate hydrolytic activity of these enzymes. Protein engineering is useful to remedy this, but it usually requires prior structural knowledge of the target enzyme, and/or relies on extensive, time-consuming screening an

I denna mikrostudie analyseras en brottslings väg från barndom till livstids straffånge i det tidiga 1800-talets svenska samhälle. Undersökningen vilar på domböcker och fängelseprotokoll i kombination med en personlig biografi i ett försök att rekonstruera och förstå brottslingens möjligheter samt vilka handlingar och vägval som till den slutliga livstidsdomen.

Streptococcus pneumoniae (pneumococcus) resides asymptomatically in the nasopharynx but can progress from benign colonizer to lethal pulmonary or systemic pathogen. Both viral infection and aging are risk factors for serious pneumococcal infections. Previous work established a murine model that featured the movement of pneumococcus from the nasopharynx to the lung upon nasopharyngeal inoculation w

Functionally graded additive manufacturing (FGAM) is a layer-by-layer manufacturing technique that allows material composition and organization to be achieved within a single volume to enable variational functionalities. Unlike traditional production methods, FGAM can produce freeform structures with customizable, site-specific properties at strategic locations. Advanced additive manufacturing pro

The ex vivo large animal retina is extensively used in research ranging from discovery of disease mechanisms to future treatment paradigms. Due to limited standardization when harvesting the tissue, the time after enucleation is often ex- tended for several hours, a factor that so far has not yet been fully characterized. The purpose of this study was to investi- gate the relationship between time

The risk of major amputation is higher after urgently planned endovascular therapy for chronic limb-threatening ischemia (CLTI) in patients with diabetes mellitus (DM). The aim of this nationwide cohort study was to compare outcomes between patients with and without DM following urgently planned open revascularization for CLTI from 2010 to 2014. Out of 1537 individuals registered in the Swedish Va

BACKGROUND: Cystic fibrosis (CF) related diabetes (CFRD) is a common complication of CF. CFRD is associated with declining lung function even before its onset. Regular screening for CFRD using oral glucose tolerance test (OGTT) is recommended. Additionally, continuous glucose monitoring (CGM) has surfaced as a possible surveillance method, but evidence for its use and concordance with OGTT has not

Accurate extrinsic calibration of wide baseline multi-camera systems enables better understanding of 3D scenes for many applications and is of great practical importance. Classical Structure-from-Motion calibration methods require special calibration equipment so that accurate point correspondences can be detected between different views. In addition, an operator with some training is usually needAccurate extrinsic calibration of wide baseline multi-camera systems enables better understanding of 3D scenes for many applications and is of great practical importance. Classical Structure-from-Motion calibration methods require special calibration equipment so that accurate point correspondences can be detected between different views. In addition, an operator with some training is usually need

This thesis focuses on how district heating utilities may work with fault handling in customer installations as a tool to reduce their return temperature levels. Reduced return temperatures would make it possible to improve the efficiency of the district heating systems and decrease their environmental impact. Faults in the customer installations cause high return temperatures that increase the re

Introduction: Occupational balance (OB) is an important concept in occupational therapy and is considered as an essential component of health and well-being. The aim of this study was to show differences in OB and quality of life (QoL) between mothers of children with cerebral palsy (CP) and typically developing children. Methods: Thirty-six mothers of children with CP and 36 mothers of typically

For aquatic scientists mesocosm experiments are important tools for hypothesis testing as they offer a compromise between experimental control and realism. Here we present a new mesocosm infrastructure—SITES AquaNET—located in five lakes connected to field stations in Sweden that cover a ~760 km latitudinal gradient. SITES AquaNet overcomes major hindrances in aquatic experimental research through

Objectives: The aim of this study was to assess the influence of transgingival compared with submerged healing on peri-implant bone maintenance around a novel, fully tapered implant in a healed crestal ridge in minipigs. Materials and methods: In each of 12 minipigs, two implants (Straumann® BLX, Roxolid® SLActive®, Ø 3.75 × 8 mm) were placed. Implants were either left for submerged or for transgi

Accurate age data are essential for reliable fish stock assessment. Yet many stocks suffer from inconsistencies in age interpretation. A new approach to obtain age makes use of the chemical composition of otoliths. This study validates the periodicity of recurrent patterns in25 Mg,31 P,34 K,55 Mn,63 Cu,64 Zn,66 Zn,85 Rb,88 Sr,138 Ba, and208 Pb in Baltic cod (Gadus morhua) otoliths from tag–recaptu