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During the recent decades, through the emerging of pump-based Parkinson (PD) therapies, it has been increasingly possible to manage motor fluctuations and dyskinesias, providing a stable levodopa plasma concentration. This can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG) or levodopa-entacapone-carbidopa intestinal gel (LECIG) via a percutaneous endoscopic gastr
The coupling between sleep-awake and dark-light cycles has played an important role in understanding external and internal biological clocks. However, how functional patterns of brain regions involved in these two coupled cycles deteriorate from circadian rhythm disturbance to circadian rhythm sleep disorder remains largely unexplored in neuroimaging research. In this study, we built a whole-brain
To effectively treat motor fluctuations and dyskinesia in advanced Parkinson's disease (PD), intestinal levodopa therapy can be carried out by continuous delivery of levodopa-carbidopa intestinal gel (LCIG; Duodopa®). LCIG is delivered with a portable pump system over tubing, entering the stomach through a percutaneous endoscopic gastrojejunostomy (PEG-J) and continuing to the proximal part of the
Triacylglycerol (TAG) serves as the primary storage lipid in plants, essential for seed germination and early seedling development. Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the last step in TAG synthesis by converting diacylglycerol (DAG) to TAG. Although functionally conserved across species, DGATs exhibit variations in substrate preference, among their other properties, hi
With the expected further electrification of society, a greater electricity demand is to be expected, requiring improved flexibility. One proposal that meets these demands is the adaptation of the current district heating power plants by adding condensing tail turbines. Condensing tail turbines allow for further expansion of steam. A simple economic analysis showed that implementing a condensing t
The X-ray solution scattering from water S(Q)H2O depends on temperature and density, a phenomenon that is utilized in, for example, temperature-resolved and ultrafast time-resolved X-ray solution scattering experiments. Whether this contribution to the acquired data arising from changes in scattering from water is merely a background signal to be subtracted or the primary subject of investigation,
Quantum measurements under realistic conditions reveal only partial information about a system. Yet, by performing sequential measurements on the same system, additional information can be accessed. We investigate this problem in the context of semi-device-independent randomness certification using sequential maximum-confidence measurements. We develop a general framework and versatile numerical m
Rotation is a natural tool in ultracold gases to break time-reversal symmetry, yet its impact on the collective excitations of supersolids remains largely unexplored. We show theoretically that tuning the rotation frequency, rather than the interparticle interactions, can trigger the superfluid-to-supersolid transition in Bose-Einstein condensates. Computing excitation spectra in the presence of v
According to defenders of the popular buck-passing account of value (the BPA of value), values should be understood in terms of reasons for pro- and con-responses. While much has been said about how to understand the normative component of the BPA of value, that is, how to understand ‘reasons’, including how to distinguish between reasons that imply value (the ‘right’ kind of reasons) and those th
Previous research underscores the importance of addressing biodiversity loss within environmental justice, introducing the concept of multi-species justice (MSJ) to recognise the rights and agency of non-human species. Despite its theoretical foundation, practical applications of MSJ remain underexplored. This paper contributes to operationalising MSJ in climate adaptation by exploring barriers to
Background: Ensuring that national governance and healthcare systems include the organization and provision of palliative care in all care settings for all patients in need is a global imperative. In cancer care, early palliative care can improve quality of life for patients and families and receiving specialised palliative care increases opportunities for care and death in the preferred place, wh
Psoriasiform eruptions have been described in patients treated with dupilumab. This case report describes an adolescent with severe atopic dermatitis who developed a widespread psoriasiform dermatitis 8 months after starting dupilumab. His therapy was switched to abrocitinib resulting in near-complete resolution of the psoriatic lesions with good atopic dermatitis control. This case adds to the li
Regional carbon dioxide (CO₂) and methane (CH₄) source contributions were analysed at two European coastal observatories, El Arenosillo (ARN) in southwestern Spain and Capo Granitola (CGR) in southern Italy, using in situ observations and STILT model simulations from 2006 to 2023, enabling source attribution to biogenic, fossil fuel, anthropogenic, and natural contributions. Model-observation agre
How does Religious Education (RE) maintain viability and legitimacy ina superdiverse society? This article addresses this question througha qualitative case study of a Buddhist-sponsored secondary school inHong Kong navigating simultaneous pressures of structural inequalityand cultural superdiversity. Drawing on participant observation, semi-structured interviews, and content analysis, we examine
Public authorities increasingly rely on consultants to navigate sustainability transitions, yet research typically treats consultants' influence as episodic and external to governance itself. This study asks how consultants instead become durable, structural participants in public-sector governance, shaping how energy-transition policies are designed, coordinated, and legitimized. Using Sweden's e
The electromechanical properties of hafnium zirconium oxide fluorite (Hf0.5Zr0.5O2, HZO) remain largely unexplored despite its widespread use as a ferroelectric in CMOS-compatible devices. Here, we demonstrate that electrostriction-driven phase instability enables a giant pseudo-piezoelectric response in epitaxial HZO thin films. Above a critical field of 24 kilovolts per centimeter, field-induced
