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Objective: Novel, highly effective disease-modifying therapies have revolutionized multiple sclerosis (MS) care. However, evidence from large comparative studies on important safety outcomes, such as cancer, is still lacking. Methods: In this nationwide register-based cohort study, we linked data from the Swedish MS register to the Swedish Cancer Register and other national health care and census
With the aim of clarifying critical care nursing, six critical care nurses, working in a Swedish intensive care unit (ICU) were each asked to narrate a care situation with which they had been satisfied or dissatisfied. The stories were tape-recorded and analysed using a phenomenological-hermeneutic approach inspired by the philosophy of Ricoeur. The themes uncovered in the analysis describe the nu
Maternal hypoglycaemia throughout gestation until gestation day (GD)20 delays foetal growth and skeletal development. While partially prevented by return to normoglycaemia after completed organogenesis (GD17), underlying mechanisms are not fully understood. Here, we investigated the pathogenesis of these changes and significance of maternal hypoglycaemia extending beyond organogenesis in non-diabe
Since the prescription of antibiotics in the hospital setting is often empiric, particularly in the critically ill, and therefore fraught with potential error, we analysed the use of antibiotic agents in Swedish intensive care units (ICUs). We examined indications for antibiotic treatment, agents and dosage prescribed among 393 patients admitted to 23 ICUs at 7 tertiary care centres, 11 secondary
The rise of populist parties and movements in general and right-wing populist parties in particular has been noted also in the public health literature. While economic and other factors behind the populist surge have been systematically analyzed in the political and social science literature, the understanding of this political phenomenon seems weak in important parts of the public health literatu
Based on the experiences of insufficient burnout in industrial fluidized bed furnaces despite adequate mixing and availability of oxidizer, the influence of potassium on CO and H2 oxidation in combustion environments was investigated. The combustion environments were provided by a laminar flame burner in a range relevant to industrial furnaces, i.e. 845 °C to 1275 °C and excess air ratios ranging
Industrial symbiosis (IS) is a key paradigm for achieving circular economy among industrial firms. Achieving new IS projects often requires outside facilitation, and intermediaries can help solidify and expand existing IS networks. While various intermediary roles have been identified in the literature, less attention has been paid to the potential challenges that intermediaries might encounter in
Peptidoglycan has been retained in chloroplasts that have evolved from cyanobacteria along some evolutionary tracks, but has seemingly been quickly eliminated during evolution of others. It has been eliminated in Rhodophyta, Chlorophyta, Pteridophyta and Spermatophyta, but has been retained in streptophyte algae, Glaukophyta, and Lycophyta. In this article questions emerging from this are raised,
H-infinity optimal control and estimation are addressed for a class of systems governed by partial differential equations with bounded input and output operators. Diffusion equations are an important example in this class. Explicit formulas for the optimal state feedback controller as well as the optimal state estimator are given. Unlike traditional methods for H-infinity synthesis, no iteration i
A material parameter identification is presented for a fully thermo-mechanically coupled material model based on full field displacement and temperature measurements. The basic theory of the inverse problem is recapitulated, focusing on the choice of the objective function, proposing a new formulation, and explaining in detail the necessary numerical treatment of experimental data during the pre-p
We introduce solution dependent finite difference stencils whose coefficients adapt to the current numerical solution by minimizing the truncation error in the least squares sense. The resulting scheme has the resolution capacity of dispersion relation preserving difference stencils in under-resolved domains, together with the high order convergence rate of conventional central difference methods
Non-linear homogenization of hyperelastic materials is reviewed and adapted to topology optimization. The homogenization is based on the method of multiscale virtual power in which the unit cell is subjected to either macroscopic deformation gradients or equivalently to Bloch type displacement boundary conditions. A detailed discussion regarding domain symmetry of the unit cell and its effect on u
The SWEDEGRAFT study (ClinicalTrials.gov Identifier: NCT03501303) tests the hypothesis that saphenous vein grafts (SVGs) harvested with the “no-touch” technique improves patency of coronary artery bypass grafts compared with the conventional open skeletonized technique. This article describes the rationale and design of the randomized trial and baseline characteristics of the population enrolled d
A key challenge in pilot training and performance assessment is the lack of insight into pilot visual behavior. Without this, it is difficult for an instructor to assess, e.g., whether pilots fail because they did not monitor the instruments or because they did not act on them, and whether pilots comply with monitoring aspects of the Standard Operating Procedures. Eye tracking provides the opportu
Purpose: Head trauma is a common complaint in emergency departments. Identifying patients with serious injuries can be difficult and generates many computerized tomographies. Reducing the number of computerized tomographies decreases both cost and radiation exposure. The aim of this study was to evaluate whether the current Scandinavian Neurotrauma Committee guidelines could be revised in such a w
