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Pediatric cancers exhibit complex evolutionary dynamics driven by genetic instability, clonal selection, epigenetic reprogramming, and microenvironmental interactions. Tumor evolution is typically characterized by branching phylogenies, where subclones with unique genetic profiles emerge at different locations and time points. Partly as a result of this diversity, advanced cancers often develop re
Introduction: Our objective was to evaluate the association of early-pregnancy body mass index (BMI) in women with gestational diabetes mellitus (GDM) with maternal, delivery, and child outcomes, and compare with pregnancies without diabetes in southeastern Sweden, including after a surge of non-European immigration. Material and Methods: A retrospective population-based observational study of all
Atrial fibrillation (AF) is associated with reduced cardiac output, which is correlated with increased symptomatic burden and declined quality of life. Predicting haemodynamic effects of AF remains challenging because of the complex interplay of multiple contributing mechanisms. Computational modelling offers a valuable tool for simulating haemodynamics. However, existing models are lacking the ca
This study provides a systematic overview of Natural Language Processing (NLP)-based frameworks for Cyber Threat Intelligence (CTI) and the early prediction of cyberattacks in Industry 4.0. As digital transformation accelerates through the integration of IoT, SCADA, and cyber-physical systems, manufacturing environments face an expanding and complex cyber threat landscape. Following the PRISMA 202
BACKGROUND: This study sought to characterize a cohort of talar neck and body fractures, focusing on fracture characteristics, associated injuries, treatment and outcome.METHODS: We reviewed adult patients registered in the Swedish Fracture Register 2011-2021 with talar neck and body fractures. A minimum 2-year follow-up was conducted for treatment outcomes.RESULTS: We included 313 patients (318 f
Anticholinergic burden is associated with cognitive impairment, especially in older individuals with neurodegenerative disorders such as Alzheimer’s disease. The objective of the study was to explore the use of drugs displaying anticholinergic properties and examine the utility of the newly developed Swedish Anticholinergic Burden Scale (Swe-ABS) in a memory clinic setting. A descriptive cross-sec
The question of the legal permissibility of heritable gene editing techniques is unsettled. The international consensus opposes clinical research and applications involving germline modifications. Building on previous work, this paper examines how international human rights law, particularly human right to science standards, can inform the regulation of this controversial advancement. We present t
Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox p
Purpose: Among visually Tau-PET-positive scans, large variation exists in the size of the visually tau-positive area. Here, we propose a metric quantifying the spatial extent of visual Tau-PET-positivity, termed “TAU-SPEX”, and evaluate associations with visual read status, neurofibrillary tangle (NFT) pathology at autopsy, and cognition. Methods: [18F]flortaucipir data from 1,645 participants (ag
Objective: The aim of this study was to assess the risk of radiation-induced cancer development in patients that have undergone an infrarenal EVAR, stratifying the relative contributions of the procedure and the preoperative and postoperative CTAs. Methods and Materials: The organ-specific absorbed radiation doses from CTA and the EVAR procedure were estimated from the radiation exposures of 95 an
Background: Previously untreated patients with severe hemophilia A exposed to factor (F)VIII are at risk of developing high-titer inhibitors. Traditionally, such children were tried on immune tolerance induction (ITI). With availability of nonfactor therapies, recommendations regarding whether to continue trying ITI and how are lacking. Objectives: To provide data to address these questions, we re
Phylogenies are central to many disciplines in biology. While disciplines such as systematics are focused on phylogenetic hypotheses themselves, other disciplines depend on robust and well-supported phylogenies in order to put biological data into evolutionary context through phylogenetic comparative studies. Examples of such fields are macroevolutionary research e.g. studying the evolution of a f
Introduction: Target volume delineation is crucial in breast cancer radiotherapy planning but involves significant interobserver variability. Deep learning (DL) models may reduce this variability, saving time and costs. However, current DL-models do not consider clinical data, such as tumor location and patient comorbidity, to adjust the target and reduce dose to organs at risk (OAR). This study c
Background and objective: The European Council advises evaluating the feasibility of organized prostate cancer testing (OPT) programs, but it is unclear whether results from screening trials can be replicated in population-based testing. The aim of this study is to compare magnetic resonance imaging (MRI) assessments and biopsy outcomes with and without a central review in two Swedish OPT programs
