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The dynamics of the C-terminus of the dUTPases from Escherichia coli and equine infectious anaemia virus (EIAV) were studied by 1H-15N nuclear magnetic resonance spectroscopy. The two enzymes differ with regard to flexibility in the backbone of the 15 most C-terminal amino acid residues, some of which are conserved and essential for enzymic activity. In the bacterial enzyme, the residues closest t
Background and Objectives. Mantle cell lymphoma (MCL) is an aggressive disease. Patients with this malignancy have a median survival of 3 years. To better understand disease progression, which is characterized by increased proliferation, we analyzed the gene expression of MCL with different proliferative indices, as determined by immunohistochemical staining for Ki-67. Furthermore, primary and rel
Denna rapport presenterar provningar och beräkningar utförda för att fastställa de mekanismer som ligger bakom sprickbildning i puts på isolering. Den här typen av puts kännetecknas av ett putsskikt, 10-20 mm, som appliceras på isolering. Isoleringen utgörs normalt av mineralull eller cellplast. För att hålla fast putsen och förebygga sprickbildning monteras ett armeringsnät som i sin tur fästs i
Typically, velocity estimators based on the estimation of the Doppler shift will suffer from a limited unambiguous velocity range. Proposed are two novel multiple carrier based velocity estimators extending the velocity range above the Nyquist velocity limit. Numerical simulations indicate that the proposed estimators offer improved estimation performance compared to other existing techniques.
Aspartylglucosaminidase (AGA, EC 3.5.1.26) is an essential enzyme in the degradation of asparagine-linked glycoproteins. In man, deficient activity of this enzyme leads to aspartylglucosaminuria (AGU), a recessively inherited lysosomal storage disease. Here we used affinity-purified polyclonal antibodies against the native AGA and its denatured subunits to establish the molecular structure and int
The aims of this study were to investigate the frequency of dysphagia among patients with acute stroke and compare non-dysphagic and dysphagic stroke patients regarding demographic aspects, performance in activities of daily living and type of neurological deficiency and to test a bedside screening tool to identify patients with dysphagia. The frequency of dysphagia was found to be 27%, or 40% if
This paper reports on a test of the validity of Pienemann's (1998) Processability Theory (PT). This theory predicts that certain morphological and syntactic phenomena are acquired in a fixed sequence. Three phenomena were chosen for this study: attributive adjective morphology, predicative adjective morphology, and subordinate clause syntax (placement of negation). These phenomena are located at s
Popular Abstract in Swedish Denna avhandling i islamologi visar hur Salman Rushdies roman Satansverserna (1988) gestaltar frågeställningar om religion, nationalitet, ras och om makt, kompromiss och autenticitet i en samtid där globala processer har lett till nya sätt att uppfatta och förhålla sig till olika traditioner. Avhandlingen visar hur Satansverserna skildrar hur människan uppfattar sig sjäThis thesis in islamology shows how Salman Rushdie's novel The Satanic Verses (1988) examines questions concerning religion, nationality, race, and power, compromise and authenticity in a time when different global processes have created new ways of perceiving and relating to different traditions. It examines how The Satanic Verses portrays how people apprehend themselves and others when the condi
Study Design. The Swedish patients included in the previous SRS brace study were invited to take part in a long-term follow-up. Objective. To investigate the rate of scoliosis surgery and progression of curves from baseline as well as after maturity. Summary of Background Data. Brace treatment was shown to be superior to electrical muscle stimulation, as well as observation alone, in the original
The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound hea
Fourth-generation (4G) systems are expected to support data rates of the order of 100 Mb/s in the outdoor environment and 1 Gb/s in the indoor/stationary environment. In order to support such large payloads, the radio physical layer must employ receiver algorithms that provide a significant increase in spectrum efficiency (and, hence, capacity) over current wireless systems. Recently, an explosion
The aim of this study was to define the most efficient way of performing cardiac MRI for anatomic information in small experimental animals, using a vertical magnetic field with a strength of 0.3 T (FONAR beta-3000M). This information may be used to improve cardiac MRI in infants and small children, since the size of a rabbit is considered comparable to that of a neonate. Experimental axial cardia
Long-term ethanol exposure is known to inhibit bradykinin-stimulated phosphoinositide hydrolysis in cultures of neuroblastoma x glioma 108-15 cells. In the present study, [3H]bradykinin binding, GTP-binding protein function, and phospholipase C activity were assayed in cells grown for 4 days in 100 mM ethanol with the aim of elucidating the molecular target of ethanol on signal transduction couple
We studied determinants of cadmium status and kidney function in nonsmoking men and women living on farms in southern Sweden. Median blood Cd (BCd) was 1.8 nmol/L (range, 0.38-18) and median urinary Cd (UCd) was 0.23 nmol/mmol creatinine (range, 0.065-0.99). The intake of Cd per kilogram body weight did not significantly differ between sexes and did not correlate with BCd or UCd, which may be expl
Two adjacent paraffin-embedded sections manifested concordance in ploidy status in 96% of cases (45/47), and the standard deviation (SD) for SPF was 2.7%. Analysis of 'micro-heterogeneity', within a distance of < or = 700 microm, yielded results for concordant ploidy status in 94% of cases, and the SD for SPF was 1.9% (n = 17). Frozen and paraffin-embedded material yielded concordant results for p
BACKGROUND: The role of cholecystokinin (CCK) and gastrin in the development and growth of pancreatic cancer cells is controversial. The aim of this study was to evaluate the role of CCK-8S, gastrin-17, bombesin, and their antagonists on cell lines from patients with pancreatic cancer. METHODS: Cell lines were established from pancreatic cancers operated on at our department. The cells were grown
