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Targeting the Mechanisms of Progression in Castration-resistant Prostate Cancer.
End-of-life care in oxygen-dependent COPD and cancer: a national population-based study.
A massive input of coarse-grained siliciclastics in the Pyrenean Basin during the PETM: the missing ingredient in a coeval abrupt change in hydrological regime
The Paleocene-Eocene thermal maximum (PETM) is represented in numerous shallow and deep marine sections of the south-central and western Pyrenees by a 2-4 m thick unit (locally up to 20 m) of clays or marly clays intercalated within a carbonate-dominated succession. This unit records a massive input into the Pyrenean Gulf of fine-grained terrestrial siliciclastics, attributed to an abrupt hydrolog
Hyaluronan in Non-Surgical and Surgical Periodontal Therapy. A Systematic Review.
AIM: To evaluate the effect of hyaluronan (HY) application as monotherapy or as adjunct to non-surgical and/or surgical periodontal therapy. METHODS: Literature search was performed according to PRISMA guidelines with the following main eligibility criteria: (a) English or German language; (b) preclinical in-vivo or human controlled trials; (c) effect size of HY evaluated histologically or clinic
Search for Invisible Decays of a Higgs Boson Produced in Association with a Z Boson in ATLAS
A search for evidence of invisible-particle decay modes of a Higgs boson produced in association with a Z boson at the Large Hadron Collider is presented. No deviation from the standard model expectation is observed in 4.5 fb(-1) (20.3 fb(-1)) of 7 (8) TeV pp collision data collected by the ATLAS experiment. Assuming the standard model rate for ZH production, an upper limit of 75%, at the 95% conf
Seasonal migration to high latitudes results in major reproductive benefits in an insect
Little is known of the population dynamics of long-range insect migrants, and it has been suggested that the annual journeys of billions of nonhardy insects to exploit temperate zones during summer represent a sink from which future generations seldom return (the “Pied Piper” effect). We combine data from entomological radars and ground-based light traps to show that annual migrations are highly a
Usage of Finance Information Systems in Developing Countries: Identifying Factors During Implementation that Impact Use
An explorative study of factors affecting implementation and use of finance information systems (FISs) in developing countries is presented. The result is based on a field study investigating implementation of a finance information system at Makerere University, Uganda. Current literature suggests that how to implement information Systems (ISs) successfully is challenging, especially in developing
Ice-Ice Collisions: An Ice Multiplication Process in Atmospheric Clouds
Ice in atmospheric clouds undergoes complex physical processes, interacting especially with radiation, which leads to serious impacts on global climate. After their primary production, atmospheric ice crystals multiply extensively by secondary processes. Here, it is shown that a mostly overlooked process of mechanical breakup of ice particles by ice-ice collisions contributes to such observed mult
The natural history of branching : approaches to the phenomenology of firstness, secondness, and thirdness.
Development of 12 polymorphic microsatellite loci in Ischnura elegans (Odonata: Coenagrionidae)
We isolated and characterised 12 polymorphic microsatellite loci for the blue-tailed damselfly Ischnura elegans by screening a genomic library enriched for microsatellite motifs. The loci showed high variability for the number of alleles, and the expected and observed heterozygosities, and thus will be useful for future molecular studies. Cross-amplification in I. graellsii, I. ramburii and I. pum
Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I
The complement system is regulated by inhibitors such as factor I (FI), a serine protease that degrades activated complement factors C4b and C3b in the presence of specific cofactors. Mutations and polymorphisms in FI and its cofactors are associated with atypical hemolytic uremic syndrome (aHUS). All 14 complement factor I mutations associated with aHUS analyzed in this study were heterozygous an
Can one blood draw replace transrectal ultrasonography-estimated prostate volume to predict prostate cancer risk?
Objective To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. Subjects and Methods The study cohort comprised previously unscreened men who underwent sextant biopsy owing to elevated PSA (3 ng/
Vietnamese sedimentary basins: geological evolution and petroleum potential
Flocculated Laponite-PEG/PEO dispersions with monovalent salt, a SAXS and simulation study.
It is well-known that clay can form lamellar structures i.e. tactoids, and recently it has been shown that the tactoid formation is dependent on the platelet diameter. To the authors knowledge, no tactoid formation has been observed for montmorillonite platelets with a diameter less than 60nm. In this study, small angle X-ray scattering in combination with coarse-grained modeling and molecular dyn
Mapping the Ultrafast Changes of Continuous Shape Measures in Photoexcited Spin Crossover Complexes without Long-Range Order
Establishing a tractable yet complete reaction coordinate for the spin-state interconversion in d(4)-d(7) transition metal complexes is an integral aspect of controlling the dynamics that govern their functionality. For spin crossover phenomena, the limitations of a single-mode approximation that solely accounts for an isotropic increase in the metal-ligand bond length have long been recognized fo
MIBG scans in patients with stage 4 neuroblastoma reveal two metastatic patterns, one is associated with MYCN amplification and in MYCN-amplified tumours correlates with a better prognosis
Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic I-123-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: "focal" (clear margins distinguishable from adjacent background
The relation between personality and the realism in confidence judgements in older adults
This study investigated the relation between personality factors, as measured by the Swedish version of the NEO-FFI questionnaire, and the realism in older adults' (aged 60-93 years, n = 1,384) probability confidence judgements of their answers to general knowledge questions. The results showed very small effect sizes for the contribution of the personality variables to the fit between the proport
Evaluating determinants for ERP use and value in Scandinavia: exploring differences between danish and swedish SMEs
In the paper we present a research model for evaluating determinants of ERP value in small and medium-size enterprises (SMEs). The model is grounded in the diffusion of innovation (DOI) model and resource-based view of the firm (RBV) theory. The research model links six DOI determinants to explain ‘ERP use’ linked with two additional determinants to explain ‘ERP value’, on which nine hypotheses ar
Capillary Condensation of Ionic Liquid Solutions in Porous Electrodes
We use classical density functional theory to investigate room temperature ionic liquid + solvent mixtures in porous electrodes. We consider those mixtures that display a miscibility gap in the bulk fluid and hence have the capacity to undergo capillary condensation in pores which preferentially attract the ionic liquid component. A novel aspect of this transition is that, when the system is at or