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Angiotensin converting enzyme (ACE) gene polymorphism in sarcoidosis in relation to associated autoimmune diseases

OBJECTIVES: To investigate the significance of ACE gene insertion/deletion (I/D) polymorphism in the frequency of autoimmune manifestations in sarcoidosis. DESIGN: In patients with sarcoidosis the ACE gene I/D polymorphism was detected with PCR on genomic DNA. The patients with sarcoidosis were divided according to the presence (n = 30) or absence (n = 32) of autoimmune manifestations. The former

Religionskritik i en postmodern tid

I en postmodern kontext blir traditionell religionskritik, som bygger på förnekandet av Guds metafysiska existens, irrelevant. Speciellt gäller detta när religionen förstås anti-realistiskt. Möjligheten till religionskritik är därmed dock inte uttömd hävdar artikeln. Exempelvis kan relevansen av en religiös reaktion inför existentiella erfarenheter ifrågasättas. En sammanvägning görs av hur religi

Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations

Three properdin deficiency phenotypes have been reported--complete deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin protein (type III)--all associated with increased susceptibility to meningococcal disease. Expression of properdin by monocytes was examined in type I deficiency and in two unrelated cases with type II deficiency, one from a Swedish and one from a Da

Mean force between like-charged macroions at high electrostatic coupling

Interactions between two like-charged macroions in the presence of their counterions confined in a cylindrical cell have been investigated by Monte Carlo simulations. The mean force and the potential of mean force (pmf) as a function of the macroion separation have been determined at conditions at which short-range attractions become significant. As the electrostatic coupling is increased, the nat

Interaction between microclimate and concrete--a prerequisite for deterioration

This paper gives an overview of the present knowledge regarding the interaction between the climatic conditions at the concrete surface and the corresponding conditions inside the concrete. The phenomena dealt with are those involved in frost damage, frost and salt scaling and reinforcement corrosion, such as temperature and moisture conditions in the near surface regions, carbonation and chloride

Increased uptake of 5-FU in experimental liver tumours by simultaneous infusion of norepinephrine

The effect of the simultaneous administration of norepinephrine and 5-fluorouracil (5-FU) on the uptake of radiolabelled 5-FU by liver tumours was studied in rats. Three different concentrations of 5-FU were used (15, 1.5 and 0.15 microgram/g body weight). The drugs were infused over a 30 min period via the hepatic artery, following cannulation of the gastroduodenal artery. The radioactivity in li

New spectroscopic information on Pd-98

Neutron deficient (98)pd nuclei were produced in the Cr-50(Ni-58,2p2 alpha)(98) Pd reaction at a beam energy of 261 MeV. A revision and extension of the level structure of (98)pd is proposed. About 40 new transitions have been assigned to, and placed in the level scheme of this nucleus. A sequence of states are candidates for the negative parity 4-quasiparticle states built on the pi g(9/2)(-3)pi

Association between age and epididymal and accessory sex gland function and their relation to sperm motility

Increased male age has been associated with significant reduction in pregnancy rates. This study investigated the association between age, the function of epididymal and accessory sex glands, and their relation to sperm motility. Ejaculates from 498 men assessed for infertility were analysed according to WHO [1999] guidelines. Seminal markers of epididymal (neutral alpha-glucosidase (NAG)), prosta

Amphiphilic polymer gel electrolytes. II. Influence of the ethylene oxide side-chain length on the gel properties

Amphiphilic polymers consisting of copolymethacrylates carrying about 26 wt % ethylene oxide [(EO)(n)] side chains of different lengths were used as matrices in gel electrolytes. The gel electrolytes were composed of 30 wt % copolymer and 70 wt % 1 M LiPF6 in a mixture of ethylene carbonate and gamma -butyrolactone (2/1 w/w). The coordination of lithium ions by the (EO)(n) side chains in competiti

Ultrastructural immunolocalization of cartilage oligomeric matrix protein (COMP) in relation to collagen fibrils in the equine tendon

The structure and organisation of the extracellular matrix, and in particular the axial alignment of type I collagen fibrils, are essential for the tensile strength of tendons. The resident tenocytes synthesize and maintain the composition of the extracellular matrix, which changes with age and maturation. Other components of the extracellular matrix include less abundant collagen types II, III, V