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Denna avhandling undersöker hur subtila former av medborgerligt motstånd tar form i Hongkongs pågående autokratisering. I en kontext präglad av vilande sociala rörelser, ökande mediecensur och digital övervakning visar studien att uttryck som inte aktivt söker uppmärksamhet ändå kan spela en viktig roll i medborgerligt engagemang. Med utgångspunkt i Hongkong efter införandet av den nationella säkThis thesis challenges the assumption that expressions that do not actively seek attention is less significant in the research of civic engagement, by foregrounding the arts of subtle resistance in contexts of social movement abeyance, heightened media censorship and digital surveillance. Drawing upon the empirical case of Hong Kong, where a National Security Law was enacted in 2020 to discourage

Background Exertional breathlessness is a limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in daily life and during standardised cardiopulmonary exercise testing (CPET). Methods Analysis of people aged ⩾40 years undergoing incremental cycle CPET. Exertional breathlessness in daily life

Background: Escalating resistance among Gram-negative pathogens limits β-lactam options. Cefepime/enmetazobactam combines a fourth-generation cephalosporin with a class A β-lactamase inhibitor. We evaluated its activity against multidrug, extensive and pandrug-resistant war-wound isolates from Ukraine.Materials and methods: We tested 215 clinical samples (2022-2023) isolated from wounded patients

Transcription factor (TF) proteins regulate gene activity by binding to regulatory regions, most importantly at gene promoters. Many genes have alternative promoters (APs) bound by distinct TFs. The role of differential TF activity at APs during tumour development is poorly understood. Here we show, using deep RNA sequencing in 274 biopsies of benign prostate tissue, localized prostate tumours and

Abstrasct Entrepreneurial ecosystems as lenses promoting innovation and entrepreneurship have attracted substantial interest in research. However attention towards the role of sector-specific actors, such as healthcare-related organizations, within entrepreneurial ecosystems remains underexplored. This paper investigates how healthcare-related organizations are conceptualized within entrepreneuria

The impact of variations in the three-dimensional structure of the genome has been recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep Hi-C sequencing with matched whole-genome sequencing, whole-genome bisulfite sequencing, 5-hydroxymethylcytosine (5hmC) sequencing and RNA sequencing across a cohort of 80 biopsy samples from patients with metastatic castrati

In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data concerning the incidence of breast and gynecological cancers are similarly inconsistent. The aim of this study was to further investigate the incidence of these so-c

BACKGROUND: Prostate cancer is a heterogenous disease, but once it becomes metastatic it eventually becomes treatment resistant. One mechanism of resistance to AR-targeting therapy is lineage plasticity, where the tumor undergoes a transformation to an AR-indifferent phenotype, most studied in the context of neuroendocrine prostate cancer (NEPC). However, activation of additional de- or trans-diff

This thesis explores the goal conflicts and trade-offs that editors in the Canadian federal public service navigate as they work to ensure that government communications products meet the objectives of the Policy on Communications and Federal Identity. The research design, which is interpretivist in approach, draws on document analysis, analytic autoethnography, and phenomenological hermeneutics t

Denna uppsats undersöker hur dionysiskt vansinne, med utgångspunkt i det Nietzscheanska apolloniska-dionysiska, gestaltas i Den hemliga historien. Uppsatsen analyserar även hur Backanterna, såväl explicit som implicit, fungerar som en intertext i Tartts roman och hur pjäsen påverkar romanens händelseutveckling.

Documented performance featuring spherical amplification.PHACE Series 2023/24 #1Wiener Konzertsaal, Berio-Saal, Wien (AT)Ensemble Phace09/01/2024From the program:Romitelli, Fausto (1963-2004, IT) – Professor Bad Trip (for ensemble and electronics) [1998-2000]

För otränade öron och ögon är det inte lätt att se vad operasång och attofysik har med varandra att göra. I det här bidraget visar dock Johan Mauritsson och Hedvig Jalhed att det finns påtagliga paralleller. Artikeln är en frukt av ett populärvetenskapligt projekt där artikelförfattarna använder just dessa beröringspunkter för att sprida såväl visdom som skönhet för både öron och ögon.

The operation of instruments and detectors in laboratory or beamline environments presents a complex challenge, requiring stable operation of multiple concurrent devices, often controlled by separate hardware and software solutions. These environments frequently undergo modifications, such as the inclusion of different auxiliary devices depending on the experiment or facility, adding further compl

The androgen receptor (AR) is the central determinant of prostate tissue identity and differentiation, controlling normal, growth-suppressive prostate-specific gene expression 1 . It is also a key driver of prostate tumorigenesis, becoming "hijacked" to drive oncogenic transcription 2-5 . However, the regulatory elements determining the execution of the growth suppressive AR transcriptional progra

Extreme value theory has been receiving much attention of late for proactively estimating crash risk through a two-step procedure that first samples extreme traffic conflicts and then estimates crash risk based on those sampled extremes. Although the existing body of research has encapsulated sampling methods within a predominant conventional technique, there is no universally accepted practice on

UNLABELLED: Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms by which cancer cells exploit the epigenetic regulatory machinery to acquire lineage plasticity and therapy resistance remain poorly understood. We identified Zinc Finger Protein 397 (ZNF397

This paper examines the practice of signposting in online counselling provided by the social services in Sweden. Specifically, it focuses on cases where online users are steered to seek offline help. The data corpus consists of 68 online chat logs (quasi-synchronous interactions) and 200 Internet question form exchanges (asynchronous interactions). The data were examined using the approach of conv