Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratifica

The four-year NATURVATION project (2016-2020), funded through the EU Horizon 2020 Programme, seeks to map and analyse existing experiences and practices in the use of nature-based solutions (NBS) to understand what enables NBS innovations and ultimately use this knowledge to inform policy and practice. One of the tasks of the project was to analyse the processes, mechanisms and tools which support

BACKGROUND: Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock. METHODS: Adult patients admit

A boundary integral equation formulation is presented for the electromagnetic transmission problem where an incident electromagnetic wave is scattered from a bounded dielectric object. The formulation provides unique solutions for all wavenumbers in the closed upper half-plane belonging to argument sets for which Maxwell's equations have unique solutions. This includes the challenging combination

The Swedish Nuclear Fuel and Waste Management Company (SKB) applied in 2011 for a permit to construct a disposal facility in the municipality of Östhammar. Given this is still an ongoing permit process the aim with this study is to nvestigate how informed the Swedish citizens are in these issues.Telephone interviews were conducted in December 2018 to January 2019. A majority of the citizens, 55%,

In birds that breed cooperatively in family groups, adult offspring often delay dispersal to assist the breeding pair in raising their young. Kin selection is thought to play an important role in the evolution of this breeding system. However, evidence supporting the underlying assumption that helpers increase the reproductive success of breeders is inconsistent. In 10 out of 19 species where the

In 2011 the Swedish Nuclear Fuel and Waste Management Company (SKB) applied for a permit to construct a disposal facility in Östhammar. The Swedish overnment is expected to make a decision in 2019. The Swedish National Council of Nuclear Waste did a survey to investigate how informed the Swedish parliamentary Members were in these issues. The first study was done with Members of Parliament (MP) in

The aim of this study is to explore the IPS implementation process in a first-episode psychosis (FEP) mental health service team in Sweden. More specifically, the study explores how integration processes and critical situations are perceived over time by team members who originated from two diverse welfare organizations. A serial interview design was used (initially, at 6 and 12 months) to describ

Purpose: To investigate access to basic human rights such as health, a standard of living adequate for health, education, work, marrying and establishing a family, and voting for prosthetic and orthotic users with lower limb disabilities in Malawi. Materials and methods: A cross-sectional design and a questionnaire were used to collect data from 83 participants. Results: Most participants reported

Purpose: To explore the experiences of persons with physical disabilities accessing and using rehabilitation services in Sierra Leone. Materials and methods: Interviews of 38 individuals with differing physical disabilities in three locations across Sierra Leone. An inductive approach was applied, and qualitative content analysis used. Results: Participants faced several barriers to accessing and

PURPOSE: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation.METHODS: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from Octo

Main problem: Self-management is essential for patients both before and after kidney transplantation and requires an adequate level of health literacy (HL), that is the ability to comprehend and process health information. Low HL is associated with poor clinical outcome and an increased risk of death. In Europe, HL has been scarcely studied. The aim of this study was to investigate the levels of H

The number of underground metro stations around the world is steadily increasing and deep stations are becoming more common. Evacuation elevators can be a way to mitigate many of the evacuation problems of deep stations, e.g., fatigue. However, the elevators need to be used by evacuees to be effective. In order to study the influence of evacuation measures on elevator usage, experiments were perfo

In recent years, parenting support has gained traction in the Swedish welfare state in both policy and practice. Parenting is seen as determining child outcomes and are thus in need of knowledge and expertise. Yet, at the same time, parents are conceptualised as experts of their own child. The intriguing paradox between parents being experts while at the same time being in need of parenting suppor