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The long and short of it : Distinct natural crystal packing strategies of Cry toxins from Bacillus thuringiensis

Bacillus thuringiensis (Bt) strains naturally produce pesticidal proteins as nanocrystalline inclusions that are extraordinarily stable in aqueous environments, but which dissolve selectively at specific pH conditions. These proteins have been used in agriculture for >50 years and are critical to global food security. The majority of previously determined Bt Cry protein structures lack the extende

Governing COVID-19 in India’s cities : state capacity, legitimation and the reproduction of public authority

Conceptualising public authority as continually performed, this paper traces the interplay between modes of legitimation, state capacity and scalar politics in governing the COVID-19 pandemic. Despite attempts to unify COVID responses nationally, governance practices differed across India’s cities: Ahmedabad (Gujarat) heightened policing, Thiruvananthapuram (Kerala) engaged its decentralised gover

Adherence to Therapy in Children with Juvenile Arthritis Treated with Infliximab.

PURPOSE:Among available tumour necrosis factor inhibitors (TNF-inhibitors) only etanercept is approved for treatment of children with polyarticular course juvenile arthritis. Nevertheless also infliximab and adalimumab are used in selected cases, especially in patients having failed on etanercept.The objective was to evaluate adherence to therapy (a combined measure of efficacy and side effects as

Against Practice : An Artistic Theory of Knowledge

As artistic research grows into an established mode of academic inquiry, it has become possible to distinguish a ruling metaparadigm which we denote as the practice paradigm. This paradigm is to a large extent based on the argument that artistic research is not equipped to produce standalone theories, but instead offers ways to develop and disseminate knowledge through sensory media and embodiment

Facet-Selective Electrostatic Assembling of 2D Mxene onto Anisotropic Single-Crystal Metal Oxides for Enhanced Photocatalysis

Designing composite photocatalytic systems with nanoscale precision is crucial. While conventional facet-selective photo-deposition successfully utilizes spherical co-catalysts, the directed deposition of pre-synthesized two-dimensional (2D) materials onto specific facets remains extremely challenging. This work demonstrates an electrostatic assembly strategy for the precise deposition of 2D trans

Update on Non-Biological and RNA-Based Therapeutics in Chronic Inflammatory Diseases : Precision Medicine Through Small Molecules

In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal antibodies—a deeper understanding of how inflammatory a

The importance of mechanical forces in chronic respiratory diseases

The lung may be the organ whose mechanical environment needs to be most finely tuned to achieve optimal function. These needs have to be fulfilled at multiple scales, from proper force transmission between the chest wall and the parenchyma to reduction of surface tension by surfactants inside the alveoli. In addition, a plethora of mechanical loads and forces takes place within the lung, from the

A Clustering-Based Method for Reducing the Search Space for Mobile Stroke Unit Allocation

Mobile Stroke Units (MSUs), which are specialised ambulances equipped with brain imaging devices and trained medical personnel, offer the potential for rapid on-site diagnosis and treatment, improving patient outcomes in prehospital stroke care. To fully realise their benefits, it is essential to strategically allocate. However, identifying optimal locations within a region for MSU deployment is t

Urban norm och rural realitet: En kritisk analys av landsbygdsbegreppet

Begreppet landsbygd används ofta som om dess innebörd vore självklar. I statistik, politik och samhällsdebatt beskrivs landsbygden ofta som motsatsen till staden: gles, avlägsen och präglad av jordbruk och natur. Denna rapport visar dock att landsbygden inte är ett enkelt eller entydigt fenomen. Tvärtom är landsbygd – eller ruralitet – ett komplext, föränderligt och relationellt begrepp som formas

Hållbar mobilitet i en polycentrisk region: Landsbygdens roll i Skånes transportsystem

Hur vi tar oss fram i vardagen påverkar inte bara vår egen livskvalitet, utan också klimatet, ekonomin och hur våra samhällen utvecklas. I Skåne, där både storstadsområden och gles landsbygd samsas i samma region, är mobilitet en särskilt viktig fråga. Den här rapporten undersöker vad ett stort antal regionala dokument säger om framtidens transporter med fokus på landsbygden.Ett av de tydligaste r

Att mäta det omätbara: Behovet av nya indikatorer för landsbygdsmobilitet

När vi pratar om mobilitet tänker många på bussar, tåg och bilar. Men på landsbygden handlar mobilitet om något större: tillgång till livet. Dagens sätt att mäta transporter är utformat för städer och fokuserar på kostnad per passagerare och restid. Dessa mått fungerar dåligt i glesbygd, där avstånd inte är ett val utan en geografisk realitet. Människor kör bil ofta för att det helt enkelt saknas

Auditory and Neural Dynamics of Predictive Speech Perception

In everyday listening, speech perception occurs under conditions where acoustic information may be incomplete or ambiguous, including background noise and variability in signal quality. Listeners must navigate ambiguous, masked or rapidly unfolding speech signal in order to comprehend spoken language. While prediction has been widely discussed and acknowledged in speech perception, less is known a

Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in ARVC

BACKGROUND: – The arrhythmogenic right ventricular cardiomyopathy (ARVC) risk calculator estimates the risk of incident sustained ventricular arrhythmia (VA) and performs well in ARVC populations meeting 2010 Task Force Criteria. However, the calculator includes no measure of left ventricular (LV) structure and function, while late gadolinium enhancement (LGE) on cardiac magnetic resonance shows p

Mobiliteshubbar: Ett verktyg för attraktiv stadsutveckling i Sölvesborgs kommun

Den här rapporten undersöker hur Sölvesborgs kommun kan stärka hållbar mobilitet och samtidigt använda centrala ytor mer effektivt genom att etablera mobilitetshubbar. En mobilitetshubb kan beskrivas som en samlad nod där flera färdmedel och tjänster möts: cykelparkering, laddning, bilpool, lånecyklar, information, bokning och möjligheter att byta mellan gång, cykel, buss och tåg. I stället för at

Proton Nuclear Magnetic Resonance Relaxation in Aqueous Sugar Solutions : Can Low-Field Nuclear Magnetic Resonance Relaxation Measurements Differentiate between “Bound” and “Free” Water?

Understanding water interactions in complex systems is crucial, as they play a key role in fields such as biochemistry, pharmaceutical formulations, and food science. Nuclear magnetic resonance (NMR) relaxation measurements have become one of the widely used methods to visualize various water characteristics owing to their noninvasive nature and ease of use. However, unambiguous data interpretatio

Periodic Inversion Domains on Step-Flow Surfaces of N-Polar GaN Grown on m-Plane Offcut 4H-SiC(0001̅)

Understanding the atomic-scale interfaces in advanced semiconductor heterostructures is essential for controlling defects, optimizing material properties, and ensuring device reliability. In this work, we present a comprehensive study of the atomic structure at Al(Ga)N interfaces in N-polar GaN high-electron-mobility transistor structures (HEMTs) via aberration-corrected annular dark field scannin