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The catalytic domain of overexpressed protein kinase C (PKC)-delta mediates phorbol 12-myristate 13-acetate (PMA)-induced differentiation or apoptosis in appropriate model cell lines. To define the portions of the catalytic domain that are critical for these isozyme-specific functions, we constructed reciprocal chimeras, PKC-delta/epsilonV5 and -epsilon/deltaV5, by swapping the V5 domains of PKC-d

Between 1980 and 1983, 10 patients received high performance silicone rubber condylar implants for the treatment of isolated degenerative changes of the scaphotrapezial joint. Early clinical and radiographic results (at a mean of 15 months) were excellent. Late follow up of these 10 together with a further 11 patients, however, showed migration of the implant and radiological signs of silicone par

Many Gram-positive bacteria express surface proteins that bind human plasma proteins. These bacterial proteins, and derivatives of them, are of interest for analysis of bacterial pathogenesis and as immunochemical tools. Well-characterized examples include the IgG-binding reagents staphylococcal protein A and streptococcal protein G, and the recently described streptococcal IgA-binding peptide Sap

Popular Abstract in Swedish I denna avhandling studerar jag tvådimensionella geometriska optimeringsproblem. Gemensamt för många praktiskt och teoretiskt intressanta problemställningar inom området är att det är mycket svårt att ta fram optimala lösningar. Det tar helt enkelt alltför lång tid att undersöka alla möjligheter för probleminstanser med stora mängder indata då beräkningstiden växer expoIn this thesis I study two-dimensional geometric optimization problems for which it is difficult to find efficient, exact, deterministic algorithms. All known solutions to these problems require time that is exponential in the total size of the input. The work done in this thesis is a contribution to the research directed at attacking and coping with such NP hard problems in computational geometry

Müntzers dramatiska levnadsöden och hans utveckling från mystiker till karismatiker och revolutionär skildras med anknytning till de orter där han verkat.

The problem of binding of microbial cells to an adsorbent matrix during in situ recovery of bioproducts from a fermentation broth has been addressed by shielding the adsorbent with a thin layer of a non-ionic polymer. Extractive bioconversion of lactic acid by integrating ion-exchange adsorption with the fermentation stage was studied. The effect of coating of the ion-exchanger with agarose on pro

Echelle mode spectra obtained with the Goddard High Resolution Spectrograph onboard the Hubble Space Telescope have been used to determine the abundances of the heavy elements Pt, Au, and Hg in the chemically peculiar HgMn-type stars kappa Cancri and chi Lupi. The abundances were determined by fitting observed line profiles with synthetically generated spectra and are found to be enhanced relative

The versatility of cuboidal Mo3S4Co clusters for the preparation of complexes with different numbers of valence shell electrons (VSE) in the cluster is described. The reaction of the geometrically incomplete cuboidal cluster salt [(eta(5)-Cp')(3)Mo3S4][pts] (pts = p-toluenesulfonate) with one molar equivalent of [Co-2(CO)(8)] afforded almost quantitatively the electroneutral 60 VSE cluster [(eta(5

The separation and characterization of salivary mucins is not straightforward because of their large size, heterogeneity, and molecular interactions. The MUC5B and MUC7 mucins are major glycoprotein components of saliva that are thought to play a vital role in maintaining oral health. MUC5B is also a major component of respiratory mucus and is produced by the tracheal and bronchial glands, while M

Questionnaire studies have indicated that patients with dental gold will more frequently have contact allergy to gold. This study aimed at investigating the relationship between contact allergy to gold and the presence and amount of dental gold alloys. A total of 102 patients were referred for patch testing because of suspicion of contact allergy. Patch tests were performed with gold sodium thiosu

The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive e