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The aim of this review is to raise awareness and knowledge among healthcare professionals and policymakers about late adverse effects in survivors of childhood leukemia. With contemporary treatment, over 90% of children with acute lymphoblastic leukemia (ALL) and over 60% with acute myeloid leukemia (AML) are cured. Large cohort studies demonstrate that 20% of ALL and most AML survivors have at le
A search is presented for non-resonant Higgs boson pair production, targeting the bbZZ, 4V (V = W or Z), VVττ, 4τ, γγVV and γγττ decay channels. Events are categorised based on the multiplicity of light charged leptons (electrons or muons), hadronically decaying tau leptons, and photons. The search is based on a data sample of proton-proton collisions at s = 13 TeV recorded with the ATLAS detector
Software development is a complex activity that needs a lot of tool assistance. Over the years there has been a lot of effort put into development of automated assistance to help with activities such as detection of issues via program analysis, or refactoring of code. Recently, the landscape of developer tool assistance is being disrupted with the entry of AI tools, such as Copilot and ChatGPT, po
The use of N-heterocyclic carbenes in conjunction with iron has been studied over the last decade for the purpose of achieving well-functioning iron-based photosensitisers. This is based on the strong σ- donating ability of the carbene, and the effect this has on the metal-based orbitals of iron, for achieving more stable excited states. This work has been done to harness this earth-abundant metal
Background: The delineation of intraprostatic lesions is vital for correct delivery of focal radiotherapy boost in patients with prostate cancer (PC). Errors in the delineation could translate into reduced tumour control and potentially increase the side effects. The purpose of this study is to compare PET-based delineation methods with histopathology. Materials and methods: The study population c
The Covid-19 pandemic sparked unprecedented political responses dramatically affecting societies, markets, and the lives of individuals. Under great uncertainty and turbulent conditions, governments adopted far-reaching political interventions to curb the pandemic. These interventions might therefore be expected to challenge key ideas underpinning liberal democracy. We analyze and compare how the
A search for the nonresonant production of Higgs boson pairs in the Formula Presented channel is performed using Formula Presented of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the CERN Large Hadron Collider. The analysis strategy is optimized to probe anomalous values of the Higgs boson self-coupling modifier Formula Presented and of the quarti
A search is performed for localized excesses in the low-mass dijet invariant mass distribution, targeting a hypothetical new particle decaying into two jets and produced in association with either a high transverse momentum photon or a jet. The search uses the full Run 2 data sample from LHC proton-proton collisions collected by the ATLAS experiment at a center-of-mass energy of 13 TeV during 2015
The ALICE experiment was proposed in 1993, to study strongly-interacting matter at extreme energy densities and temperatures. This proposal entailed a comprehensive investigation of nuclear collisions at the LHC. Its physics programme initially focused on the determination of the properties of the quark–gluon plasma (QGP), a deconfined state of quarks and gluons, created in such collisions. The AL
Breast cancer is the most frequently diagnosed cancer in females globally. However, we know relatively little about trends in males. This study describes United Kingdom (UK) secular trends in breast cancer from 2000 to 2021 for both sexes. We describe a population-based cohort study using UK primary care Clinical Practice Research Datalink (CPRD) GOLD and Aurum databases. There were 5,848,436 elig
We report the discovery and characterization of a small planet, TOI-1408 c, on a 2.2 day orbit located interior to a previously known hot Jupiter, TOI-1408 b (P = 4.42 days, M = 1.86 ± 0.02 M Jup, R = 2.4 ± 0.5 R Jup) that exhibits grazing transits. The two planets are near 2:1 period commensurability, resulting in significant transit timing variations (TTVs) for both planets and transit duration
Decays of Ξb− and Ωb− baryons to Λc+h−h′− final states, with h−h′− being π−π−, K−π− and K−K− meson pairs, are searched for using data collected with the LHCb detector. The data sample studied corresponds to an integrated luminosity of 8.7 fb−1 of pp collisions collected at centre-of-mass energies s = 7, 8 and 13 TeV. The products of the relative branching fractions and fragmentation fractions for
This essay examines the Bavarian physician, mining engineer, and Catholic romantic philosopher Franz von Baader's (1765-1841) enigmatic claim that we think because we are thought with the help of the moral theologian Servain Pinckaers OP (1925-2008) and the psychologist Mihaly Csikszentmihalyi (1934-2021). Using Pinckaers' idea of 'fontal knowledge' and Csikszentmihalyi's notion of flow, I interprThis essay examines the Bavarian physician, mining engineer, and Catholic romantic philosopher Franz von Baader's (1765-1841) enigmatic claim that we think because we are thought with the help of the moral theologian Servain Pinckaers OP (1925-2008) and the psychologist Mihaly Csikszentmihalyi (1934-2021). Using Pinckaers' idea of 'fontal knowledge' and Csikszentmihalyi's notion of flow, I interpr
Measurements of the branching fraction ratio B(ϕ→μ+μ−)/B(ϕ→e+e−) with Ds +→π+ϕ and D+→ π+ϕ decays, denoted Rϕπ s and Rϕπ d, are presented. The analysis is performed using a dataset corresponding to an integrated luminosity of 5.4 fb−1 of pp collision data collected with the LHCb experiment. The branching fractions are normalised with respect to the B+ → K+J/ψ(→ e+e−) and B+ → K+J/ψ(→ μ+μ−) decay m
