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Cortical microvascular raspberries and ageing : an independent but not exclusive relationship
Introduction: Raspberries are cerebral microvascular formations of unknown origin, defined as three or more transversally sectioned vascular lumina surrounded by a common perivascular space. We have previously demonstrated an increased raspberry density in the cortex of patients with vascular dementia and cerebral atherosclerosis, while studies by other authors on overlapping and synonymously defi
Prolonged Sick Leave Before and After Diagnosis of Generalized Pustular Psoriasis : A Swedish Population-based Register Study
The aim of this study was to analyse sick leave in generalized pustular psoriasis, the most severe form of pustular psoriasis. Prolonged sick leave of >14 days was analysed for 502 patients with generalized pustular psoriasis compared with controls with psoriasis vulgaris and matched controls from the general population. Using data from the Swedish National Patient Register, and the Longitudinal i
Evaluation of intensity-modulated electron FLASH radiotherapy in a clinical setting using veterinary cases
Purpose: The increased normal tissue tolerance for FLASH radiotherapy (FLASH-RT), as compared to conventional radiotherapy, was first observed in ultra-high dose rate electron beams. Initial clinical trials in companion animals have revealed a high risk of developing osteoradionecrosis following high-dose single-fraction electron FLASH-RT, which may be related to inhomogeneities in the dose distri
Adaptation to climate change through dispersal and inherited timing in an avian migrant
Many organisms fail to adjust their phenology sufficiently to climate change. Studies have concentrated on adaptive responses within localities, but little is known about how latitudinal dispersal enhances evolutionary potential. Rapid adaptation is expected if dispersers from lower latitudes have improved synchrony to northern conditions, thereby gain fitness and introduce genotypes on which sele
The C-reactive protein Albumin ratio was not consistently associated with cardiovascular and all-cause mortality in two community-based cohorts of 70-year-olds
C-reactive protein (CRP)/Albumin ratio (CAR) seems to mirror disease severity and prognosis in several acute disorders particularly in elderly patients, which we aimed to study. As method we use a prospective study design; the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; n = 912, women 50%; mean age 70 years, baseline 2001 and 2004, median follow-up 15.0 years, end of fo
An introduction to the desert Fathers. By John Wortley. Pp. xxiv + 190 incl. 2 maps. Cambridge-New York : Cambridge University Press, 2019. £17.99 (paper). 9781108705727
Coalition dynamics : advances in the study of the coalition life cycle
In parliamentary democracies, elections distribute the seats in parliament, but who gets into government and determines the policy agenda over the course of the legislative term is decided upon after the elections, in negotiations between the political parties. This introduction to the special issue discusses research concerning dynamic approaches to coalition governments. A dynamic approach impli
Snack quality and snack timing are associated with cardiometabolic blood markers : the ZOE PREDICT study
Background: Snacking is a common diet behaviour which accounts for a large proportion of daily energy intake, making it a key determinant of diet quality. However, the relationship between snacking frequency, quality and timing with cardiometabolic health remains unclear. Design: Demography, diet, health (fasting and postprandial cardiometabolic blood and anthropometrics markers) and stool metagen
Mental health from 5 years before to 10 years after bariatric surgery in adolescents with severe obesity: a Swedish nationwide cohort study with matched population controls
Internet-delivered cognitive behavioral therapy for adolescents with insomnia : Feasibility and preliminary efficacy
Background: Insomnia is common in adolescents. This study evaluated feasibility and preliminary efficacy of a six-week internet-delivered cognitive-behavioral therapy for insomnia (ICBT-I) in adolescents. Methods: In this uncontrolled pilot study, participants (n = 27, 78% female) completed assessments pre- and post intervention. Data on recruitment, adherence to treatment, treatment activity, sat
Effects of Value-Belief-Norm Theory, ESG, and AI on Space Tourist Behavior for Sustainability With Three Types of Space Tourism
Since reusable launch vehicles have revolutionized access to space, space tourism has received enormous policy and research attention. However, such growth is occurring within a wider context of concerns over climate change, emissions, and space debris. Although the space industries have enormous environmental impacts, few studies have been undertaken on the sustainability of space tourism. Theref
Monoamines' role in islet cell function and type 2 diabetes risk
The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Mela
A Boundary Tool for Multi-stakeholder Sustainable Business Model Innovation
Sustainable business model innovation cannot reach its full sustainability potential if it neglects the importance of multi-stakeholder alignment. Several studies emphasize the need for multi-stakeholder collaboration to enable sustainable business model innovation, but few studies offer guidance to companies for engaging in such a collaborative process. Based on the concept of boundary work, this
Health care use after severe respiratory tract infections in children aged 0 to 5 years
Aim: To explore whether children in specialist care with COVID-19 have increased post-discharge health care use when compared with children in specialist care with 1) respiratory syncytial virus (RSV) infection, and 2) other respiratory tract infections (RTIs). Methods: In 34,214 children aged 1 month to 5 years who were registered as having one or more hospital visit (outpatient or inpatient) wit
Sweden
Treatment for retinopathy of prematurity in Sweden 2008–2021 : Reduced gestational age of treated infants and remaining differences in treatment type and recurrence rates between hospitals
Purpose: This study aimed to investigate various aspects of treatment for retinopathy of prematurity (ROP) in Sweden over the past 14 years, nationally and at a hospital level. Methods: Data on screening and treatment for ROP in infants born in Sweden from 2008 to 2021 were extracted from the national ROP register, SWEDROP. During this period, Swedish screening guidelines were reduced from gestati
Predictive Factors for Delayed Gastric Emptying After Pancreatoduodenectomy : A Swedish National Registry-Based Study
Background: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). DGE causes prolonged hospital stay and a decrease in quality of life. This study analyzes predictive factors for development of DGE after PD, also in the absence of surgical complications. Method: Data from the Swedish National Pancreatic Cancer Registry for patients undergoing standard and pyloru
Reproducibility of cerebral blood flow, oxygen metabolism, and lactate and N-acetyl-aspartate concentrations measured using magnetic resonance imaging and spectroscopy
In humans, resting cerebral perfusion, oxygen consumption and energy metabolism demonstrate large intersubject variation regardless of methodology. Whether a similar large variation is also present longitudinally in individual subjects is much less studied, but knowing the time variance in reproducibility is important when designing and interpreting longitudinal follow-up studies examining brain p
What Makes Tourists Use Public Transport? Value-Belief-Norm Theory, Environmental, Social, and Governance Factors, and the Sustainable Development Goals
Fifty percent of emissions must be cut by 2030 and net zero emissions by 2050 to keep global warming below 1.5°C. Transport is a major component of tourism’s contribution to climate change. Therefore, encouraging tourists to use less energy intensive public transport is an important strategy in reducing tourism emissions. Despite the crucial role of public transport for sustainable tourism, the ar