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The stringent response is a conserved stress–adaptation program in bacteria, mediated by the alarmones (p)ppGpp that reprogram transcription, translation, and metabolism. This mini–review surveys mechanistic, physiological, and evolutionary facets of alarmone singnaling across two classes of RelA/SpoT homologue (RSH) enzymes: multidomain-containing long RSHs and small alarmone synthetases/hydrolas
Background: The use of high-flow oxygen therapy (HFOT) compared with standard low-flow oxygen therapy (LFOT) may improve outcomes in people with oxygen-dependent chronic respiratory failure (CRF). The primary aim of this multicentre trial was to evaluate HFOT in addition to LFOT, compared with regular LFOT in people with CRF due to chronic obstructive pulmonary disease (COPD) or interstitial lung
Why, despite decades of warnings and solutions, does unsustainable consumption still persist? What keeps societies locked into business as usual even when the consequences are clear? This book contends that part of the answer lies in the myths we adhere to – powerful narratives that normalise the status quo, limit imagination and delay the transition to sustainability. Gathering leading scholars f
The Haro 11 galaxy merger is the closest known Lyman continuum (LyC) leaker and a strong Lyman-α (Lyα) emitter, making it an important analogue of the high-z galaxies that reionised the early Universe. To investigate how Haro 11’s properties arise, we perform a radiation hydrodynamics simulation of the merger, and create mock observations of LyC, Lyα, and Hα, from which we compute their luminositi
Background: Standardized definitions of autoimmune disease (AD) are lacking. Therefore, we aim to propose a definition of AD for register-based research and estimate the burden of AD in Sweden as registered in the National Patient Register (NPR) from 1980 to 2023. Methods: Leveraging the NPR, we defined AD as having at least two relevant International Classification of Diseases (ICD) codes represe
The optical response of gold-silver (Au-Ag) alloy nanoparticles is strongly influenced by their localized surface plasmon resonance (LSPR), which can be tuned by varying the particle composition. Accurate simulation of LSPR, often performed using Mie theory, critically depends on the choice of dielectric function, yet available datasets for gold, silver, and their alloys vary widely. In this work,
Distributed multiple-input multiple-output (MIMO), also known as cell-free massive MIMO, emerges as a promising technology for sixth-generation (6G) systems to support uniform coverage and reliable communication. For the design and optimization of such systems, measurement-based investigations of real-world distributed MIMO channels are essential. In this paper, we present a sub-6 GHz indoor chann
The residential sector presents one of the most pressing decarbonisation challenges, especially within historically gas-dependent nations such as the UK. Compounding this challenge, issues of social acceptance have slowed efforts to advance the residential decarbonisation agenda in the UK context. To date, existing technologies such as heat pumps and smart meters, as well as emerging technologies
This article examines how embodied Virtual Reality (VR), when used as a participatory research method, can support the narrative sovereignty of refugees from the Global South by recognising their stories as key sources of knowledge production. This approach challenges dominant humanitarian and state discourses that often frame refugees as passive victims in need of saving. The article critiques th
This review synthesises current evidence on the clinical utility of foam-based posturography in the assessment of vestibular pathologies. It critically evaluates: (1) the physiological mechanisms underlying foam posturography and its capacity to determine vestibular contributions; (2) methodological variability across testing protocols, including differences in foam properties, stance conditions a
Low barriers to trade and access to international capital markets have long been argued to improve economic conditions in a country. However, there is less consensus on the impact of economic globalization on the distribution of those gains across society. There are several possible explanations for the conflicting findings in the existing literature, perhaps most notably endogeneity issues that p
Objective Type I interferons (IFN) drive systemic lupus erythematosus (SLE) pathogenesis. Some patients develop neutralizing IFN autoantibodies (anti-IFN ab), which theoretically could modify disease activity. We aimed to determine the prevalence of anti-IFN ab in patients with SLE, identify the age and when during the disease course of anti-IFN ab emerge, and assess their association with organ d
Background: Postoperative lymph node irradiation can affect shoulder morbidity in breast cancer patients, yet widely accepted dose-volume constraints for the shoulder joint are lacking. The SENOMAC trial randomized patients with breast cancer and 1–2 sentinel lymph node (SLN) macrometastases to axillary lymph node dissection (ALND) or SLN biopsy only. We aimed to analyze the association between th
Finding the optimal subset of individuals to observe in order to obtain the best estimate of the average opinion of a society is a crucial problem in a wide range of applications, including policy-making, strategic business decisions, and the analysis of sociological trends. We consider the opinion vector X to be updated according to a DeGroot opinion dynamical model with stubborn agents, subject
Bacteriophages must overcome diverse bacterial immune systems, yet the molecular principles enabling such escape remain poorly understood. Here, we show that the phage homing endonuclease SegB facilitates immune evasion by promoting the segmental amplification of anti-defense loci. The antiphage defense Septu inhibits phage T6 replication by cleaving the variable loop of tRNATyr. We show that SegB
Rapid warming in the Arctic is transforming northern ecosystems and altering their role in the global carbon cycle. Rising temperatures are driving shifts in vegetation composition, phenology, and ecosystem functioning, including earlier growing seasons and the expansion of shrubs across tundra landscapes. These changes influence surface energy balance, carbon uptake, and climate feedbacks, yet su
